A 50-year experience with autoimmune hepatitis: and where are we now?

Mackay, Ian R.

doi:10.1007/s00535-010-0325-2

Cited by 9 publications

(11 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The liver lesions of “classic” SLE are relatively trivial compared with those of autoimmune “lupoid” hepatitis (2, 14). However, cases of lupoid hepatitis have been reported in SLE patients, suggesting that an overlap syndrome of SLE-AIH may exist (13).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

“Lupoid hepatitis” in SLE patients and mice with experimental lupus

Shumyak

Yang

Han

et al. 2016

Clinical Immunology

View full text Add to dashboard Cite

The unusual subset of patients with severe hepatitis, hypergammaglobulinemia, arthritis, and LE cells in the blood reported by Henry Kunkel and others suggested to these investigators that “lupoid” hepatitis might share pathogenic mechanisms with SLE. More than half a century later, the etiology of autoimmune hepatitis remains unclear. The occurrence of autoimmune hepatitis in a small fraction (about 3%) of SLE patients in our lupus cohort and in two mouse models of SLE supports their conclusion that lupoid hepatitis may be share pathogenic mechanisms with SLE. The development of autoimmune hepatitis in mice with pristane-induced lupus provides an opportunity to further explore the potential link between these two autoimmune disorders.

show abstract

Section: Resultsmentioning

confidence: 99%

“…For an extensive review of the history of lupoid hepatitis, see (2). The initial patients in Kunkel’s case series, predominantly young women, had a history suggestive of acute hepatitis and developed cirrhosis (1).…”

Section: Introductionmentioning

confidence: 99%

“Lupoid hepatitis” in SLE patients and mice with experimental lupus

Shumyak

Yang

Han

et al. 2016

Clinical Immunology

View full text Add to dashboard Cite

show abstract

“…Our attempts to find in available databases the linkage between an appearance of autoantibodies to these enzymes and specific human autoimmune diseases or reproductive dysfunctions in women have failed. A link between actin autoantibodies and autoimmune diseases is well known, and it was found in patients with autoimmune liver diseases (12,13), celiac disease (14), and rheumatoid arthritis (15). The endoplasmin also known as Heat Shock Protein 90 kDa Beta Member 1 may participate in immune response in RM patients.…”

Section: Discussionmentioning

confidence: 99%

Detection of novel auto-antigens in patients with recurrent miscarriage: description of an approach and preliminary findings

et al. 2014

View full text Add to dashboard Cite

AimTo develop and test a protocol for isolation of potential auto-antigens from chorionic tissue that may be linked to recurrent miscarriage (RM).MethodsThe strategy included: 1) isolation of IgGs tightly bound to chorionic tissue of RM patients by protein G chromatography; 2) construction of affinity columns using the chorionic antibodies for isolation of auto-antigens; 3) enrichment of auto-antigens from detergent extracted solution of chorionic proteins by affinity chromatography; 4) separation by dodecyl sulfate-electrophoresis followed by matrix-assisted laser desorption/ionization-time of flight mass spectrometry identification.ResultsFive potential auto-antigens were detected: neutral alpha-glucosidase AB, endoplasmin, transitional endoplasmic reticulum ATPase, putative endoplasmin-like protein, and cytoplasmic actin 2.ConclusionsWe developed a strategy for identification of auto-antigens in the chorionic tissue of women with RM, which could be of diagnostic and prognostic value.

show abstract

“…Notwithstanding, there is a near invariable presence in serum of one or another of several relatively disease-specific autoantibody reactants, albeit demonstrable at various levels of sensitivity and specificity. Detailed discussion of these and other clinical issues are beyond the scope of this review (see Mackay, 2011aMackay, , 2011b. The present enquiry is pitched more towards the origin and meaning of these abnormal reactants.…”

Section: Serum Autoantibodiesmentioning

confidence: 97%

“…Other autoantibody specificities recognized in AIH are described elsewhere (Bogdanos et al, 2008;Mackay, 2011aMackay, , 2011b. Included are SLA/LP, molecularly identified as selenocysteine synthase, and liver cytosol type 1 (LC1).…”

Section: Serum Autoantibodiesmentioning

confidence: 98%