A 6‐month home‐usage trial of 0.1% and 0.2% delmopinol mouthwashes (II). Effects on the plaque microflora

Abstract

The effects of 0.1% and 0.2% delmopinol mouthwashes on supragingival plaque flora were investigated in a 6-month home-use study. 141 subjects were studied from whom plaque was collected at baseline, 12, 24, and 36 weeks. Overall, there were no consistent effects on microscopic or total counts. However, there was a significant reduction in the proportion of dextran-producing streptococci in the active groups compared to the control group throughout treatment. There was no colonisation by Candida or Gram-negative aerobic bacilli in the active groups nor was there any decrease in susceptibility to delmopinol. Delmopinol appears to mediate its anti-plaque effect without causing a major shift in bacterial populations, although dextran-producing bacteria appear to be affected, which may have relevance to this agent's mode of action.

Randomized controlled clinical trials on agents used for chemical plaque control

“…The long‐term study by Elworthy et al. (105) documented the changes in microbial flora as a result of the use of this agent. No major shifts were observed.…”

Evaluation of 0.2% delmopinol mouth rinse for prevention of peri‐implant mucositis and peri‐implantitis: A randomized controlled canine study

“…Delmopinol is a low molecular weight substituted aminoalcohol which has been shown to be effective clinically in the inhibition of plaque and gingivitis at concentration of 0.2% . Its efficacy is thought to be based on the ability to interfere with the bacterial matrix formation, inhibit the adhesion of bacteria and cause a looser biofilm that is easier to remove …”

“…Delmopinol may also reduce cell‐to‐cell adhesion by changing the colloidal stability of bacterial suspensions and by detaching or solubilizing surface structures of oral bacteria . A 6‐month home‐usage trial of 0.1% and 0.2% delmopinol mouthwashes, has demonstrated no serious perturbation of the oral flora nor development of resistance to the agent …”

Antiplaque and Antigingivitis Toothpastes

“…Their mechanism of action is through the inhibition and disruption of the biofilm extracel- lular matrix, and therefore they are not antimicrobial agents since they disrupt an already established biofilm. They also inhibit glycan synthesis by Streptococcus mutans [28,29] and thus reduce bacteria acid production [30]. Delmopinol has been marketed as toothpaste in concentrations of 0.2%, in combination with 0.11% fluoride as sodium fluoride (NaF).…”