A 6-month randomized clinical trial of bimatoprost 0.03% versus the association of timolol 0.5% and latanoprost 0.005% in glaucomatous patients

Abstract

Bimatoprost and the association of latanoprost plus timolol were equally effective in lowering the IOP in glaucomatous patients previously treated with timolol. Latanoprost plus timolol showed a better ocular safety profile.

Adverse periocular reactions to five types of prostaglandin analogs

“…The appearance frequencies of eyelid pigmentation with the use of PG analogs are reported to be 0, 2 0.8, 3 In these previous studies, [2][3][4][5][6][7][8][9][10][11][12][13][14][15] there were variations in the frequency of the administration period, method used for judging adverse reactions (by slit lamp or images), and race. Owing to differences in the administration period, the appearance frequency of eyelid pigmentation was 1.5-2.9% 4 in patients with o3 months of medication use and 0-25.9% 2,3,[5][6][7][8]15 in patients with 43 months of medication use.…”

“…Owing to differences in the administration period, the appearance frequency of eyelid pigmentation was 1.5-2.9% 4 in patients with o3 months of medication use and 0-25.9% 2,3,[5][6][7][8]15 in patients with 43 months of medication use. The appearance frequency of changes in eyelashes was 0-33.8% 4,10,12,15 in patients with o3 months of use and 0.7-77% [5][6][7][8][9][10][11]13,14 in patients with 43 months of use. In this study, the administration period was 43 months for all five types of PG analogs, and the appearance frequency ranged from 0 to 6.0% for eyelid pigmentation and 8.0 to 54.0% for eyelash changes.…”

“…The method to determine adverse reactions was comparison of pictures of eyes obtained before and after administration or by examination at every check-up. The appearance frequency of eyelid pigmentation was 3.3-25.9% [6][7][8][9] by picture judgment and 0-5.8% 2-5 by slit lamp judgment at every check-up; this suggests that the appearance frequency determined by picture judgment is higher. The method of comparing pictures of the left eye with those of the right eye (0-6.0%) provided results that were closer to the results obtained by slit lamp judgment.…”

“…The appearance of adverse reactions can be judged more accurately by comparing pictures of the eyes obtained before and after treatment, as noted in previous studies. [6][7][8][9][10]12,13 In this study, we did not photograph the pictures of eyes before administration. Therefore, we were not able to compare pictures of before and after administration.…”

“…[2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] Of these, changes in eyelashes, eyelid pigmentation, iris pigmentation, hypertrichosis around the eye, appearance of iritis, and deepening of the upper eyelid sulcus are thought to be characteristic adverse reactions to PG analogs. The frequency of eyelid pigmentation was reported to be between 0 and 25.9%, [2][3][4][5][6][7][8][9] and eyelash bristles are reported to occur in 0-77.0% of patients [4][5][6][7][8][9][10][11][12][13][14][15] with PG analog use. However, no study has compared the frequency of occurrence of eyelid pigmentation and eyelash bristles with the use of five types of PG analogs.…”