A 9-year longitudinal study on trajectories of aggressive and depressive symptoms in male and female children with overweight

Cerniglia, Luca; Cimino, Silvia; Erriu, Michela; Ježek, Stanislav; Almenara, Carlos A.; Tambelli, Renata

doi:10.1186/s13104-019-4734-x

Cited by 7 publications

(8 citation statements)

References 23 publications

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“…[1,45]). Together with the findings that obesity and aggression share overlapping genes [46] and are co-morbid in epidemiological studies [47,48], indicate that obesity and aggression share common risk factors; plausibly GLP-1 signaling. Indeed, the potential role of GLP-1R for aggression is unknown.…”

Section: Introductionmentioning

confidence: 70%

Activation of glucagon-like peptide-1 receptors reduces the acquisition of aggression-like behaviors in male mice

et al. 2022

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Aggression is a complex social behavior, which is provoked in the defense of limited resources including food and mates. Recent advances show that the gut-brain hormone ghrelin modulates aggressive behaviors. As the gut-brain hormone glucagon-like peptide-1 (GLP-1) reduces food intake and sexual behaviors its potential role in aggressive behaviors is likely. Therefore, we investigated a tentative link between GLP-1 and aggressive behaviors by combining preclinical and human genetic-association studies. The influence of acute or repeated injections of a GLP-1 receptor (GLP-1R) agonist, exendin-4 (Ex4), on aggressive behaviors was assessed in male mice exposed to the resident-intruder paradigm. Besides, possible mechanisms participating in the ability of Ex4 to reduce aggressive behaviors were evaluated. Associations of polymorphisms in GLP-1R genes and overt aggression in males of the CATSS cohort were assessed. In male mice, repeated, but not acute, Ex4 treatment dose-dependently reduced aggressive behaviors. Neurochemical and western blot studies further revealed that putative serotonergic and noradrenergic signaling in nucleus accumbens, specifically the shell compartment, may participate in the interaction between Ex4 and aggression. As high-fat diet (HFD) impairs the responsiveness to GLP-1 on various behaviors the possibility that HFD blunts the ability of Ex4 to reduce aggressive behaviors was explored. Indeed, the levels of aggression was similar in vehicle and Ex4 treated mice consuming HFD. In humans, there were no associations between polymorphisms of the GLP-1R genes and overt aggression. Overall, GLP-1 signaling suppresses acquisition of aggressive behaviors via central neurotransmission and additional studies exploring this link are warranted.

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Section: Introductionmentioning

confidence: 70%

Activation of glucagon-like peptide-1 receptors reduces the acquisition of aggression-like behaviors in male mice

et al. 2022

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“…This study provides the evidence of a gender difference for the association of BMI with SCQ. Overweight female children showed increasing levels of depressive symptoms 22 and depressed people usually avoid social situations 23 . According to our cross-sectional study, attention should also be paid to high BMI for girls with poor social function.…”

Section: Discussionmentioning

confidence: 99%

Abnormal body mass index may be related to poor social function of female children by a propensity score matching analysis

You

Jin

Liu

et al. 2021

Sci Rep

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This study sought to estimate the association of children’s body mass index (BMI) with their social function in Shanghai China. A large population-based cross-sectional study based on a propensity score matching (PSM) analysis was conducted. BMI was compared according to social communication questionnaire (SCQ) classification, and then SCQ score was compared in terms of BMI grouping before and after PSM. A positive SCQ was considered to indicate poor social communication and a negative SCQ was then supposed to be normal. After 1:3 matching, a total of 7563 children aged 3–12 years were included in analysis. There were statistically significant positive correlation of BMI with SCQ scores for obese females of school age (R2 = 0.043, p < 0.001) and negative correlation of these two variables for school-aged females with malnutrition (R2 = 0.047, p = 0.027). In conclusion, BMI may be characterized as one of predictive factor for poor social function of these children.

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“…Other studies, conversely, addressed the effect of maternal depression over long periods of time but with a focus on children's early childhood and their adolescence, with little if any attention to the intermediate developmental stages (toddlerhood, childhood, latency, early adolescence). The present study, instead, made evaluations over a broad time frame, including the developmental phase around 8 years of age that has been demonstrated to be a critical point in determining future positive or negative outcomes in children's psychological well being, probably due to an increased capacity of emotion regulation and increased social skills [47][48][49].…”

Section: Discussionmentioning

confidence: 99%

The stable component of maternal depressive symptoms predicts offspring emotional and behavioral symptoms: a 9-years longitudinal study

Cerniglia¹,

Dentale²,

Tambelli³

et al. 2020

BMC Psychol

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Background Maternal sub-threshold and non-clinical depression and its possible outcomes on offspring internalizing/externalizing symptoms has received growing attention in recent years because of its significant worldwide prevalence. Methods Through a Latent State-Trait Analysis approach (LST), this longitudinal study aimed to identify a stable component of non-clinical maternal depression across a temporal interval of 6 years (measured through the Symptom Check-List-90/R) and to determine the effect of this component on children’s emotional and behavioral functioning (measured through the Child Behaviour Check-List) at age 12 years. Results LST analysis showed that maternal depressive symptoms tended to remain stable within individuals across 6 years of observation strongly contributing to children’s internalizing/externalizing and dysregulation symptoms. Conclusions The current longitudinal analysis of maternal and child data revealed that a stable component of maternal depressive symptoms reliably predicted a wide range of child emotional and behavioral symptoms at 12 years of age.

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A 9-year longitudinal study on trajectories of aggressive and depressive symptoms in male and female children with overweight

Cited by 7 publications

References 23 publications

Activation of glucagon-like peptide-1 receptors reduces the acquisition of aggression-like behaviors in male mice

Activation of glucagon-like peptide-1 receptors reduces the acquisition of aggression-like behaviors in male mice

Abnormal body mass index may be related to poor social function of female children by a propensity score matching analysis

The stable component of maternal depressive symptoms predicts offspring emotional and behavioral symptoms: a 9-years longitudinal study

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