A, B, O blood groups and hepatosplenic form of schistosomiasis mansoni (Symmer's fibrosis)

Pereira, Fausto Edmundo Lima; Bortolini, Eliete Rabbi; Carneiro, J.L; Rogério, Carlos; Silva, Mello da; Neves, Ricardo Carneiro

doi:10.1016/0035-9203(79)90224-4

Cited by 25 publications

(20 citation statements)

References 2 publications

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“…One of the host factors implicated in the variation in helminth infection across settings is the ABO blood group (Khattab et al, 1968;Camus et al, 1977;Pareira et al, 1979;Trangle et al, 1979;Ndamba et al, 1997). However, the nature of this association remains uncertain (Gabr & Mandour, 1991;Cooper et al, 1993;Ndamba et al, 1997).…”

Section: Introductionmentioning

confidence: 94%

The association between multiple intestinal helminth infections and blood group, anaemia and nutritional status in human populations from Dore Bafeno, southern Ethiopia

et al. 2013

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In this cross-sectional study, the associations between helminth infections and ABO blood group, anaemia and undernutrition were investigated in 480 febrile outpatients who visited Dore Bafeno Health Centre, southern Ethiopia, in December 2010. Stool specimens were processed using the Kato-Katz method and examined for intestinal helminth infections. Haemoglobin level was measured using a HemoCue machine and blood group was determined using an antisera haemagglutination test. Nutritional status of the study participants was assessed using height and weight measurements. Among the study participants, 50.2% were infected with intestinal helminths. Ascaris lumbricoides (32.7%), Trichuris trichiura (12.7%), Schistosoma mansoni (11.9%) and hookworm (11.0%) were the most frequently diagnosed helminths. The odds of infection and mean eggs per gram of different intestinal helminth species were comparable between the various blood groups. Among individuals who were infected with intestinal helminth(s), the mean haemoglobin level was significantly lower in individuals harbouring three or more helminth species and blood type AB compared to cases with double or single helminth infection and blood type O, respectively. The odds of being underweight was significantly higher in A. lumbricoides and T. trichiura infected individuals of age ≤ 5 and ≥ 20 years, respectively, when compared to individuals of the matching age group without intestinal helminths. In conclusion, infection with multiple intestinal helminths was associated with lower haemoglobin level, which was more severe in individuals with blood type AB. Future studies should focus on mechanisms by which blood group AB exacerbates the helminth-related reduction in mean haemoglobin level.

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Section: Introductionmentioning

confidence: 94%

The association between multiple intestinal helminth infections and blood group, anaemia and nutritional status in human populations from Dore Bafeno, southern Ethiopia

et al. 2013

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“…Development of severe morbidity differed in persons of various racial backgrounds (32). A tentative relationship between the development of HS disease and the occurrence of blood group A has been proposed (55,182). Similarly, a correlation has been observed between susceptibility to hepatosplenism and the expression of HLA-A1 and HLA-B5 histocompatibility antigens (1).…”

Section: Egg-induced Granulomatous Pathologymentioning

confidence: 99%

Immunopathology of Schistosoma mansoni infection

1989

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Schistosomiasis mansoni is a chronic helminthic disease that affects about 100 million people in the tropics. The worms have a life span of 5 to 10 years, and they live in the mesenteric veins of the host. Lightly infected individuals are asymptomatic or manifest mild intestinal symptoms. Heavily infected individuals often develop severe morbidity with hepatosplenomegaly, sometimes with a fatal outcome. Morbidity is attributed to the strong humoral and T-cell-mediated host immune responses developed to a variety of parasite antigens and expressed as tissue inflammations. The immunopathology includes dermatitis, immune complex-mediated kidney disease, and, chiefly, T-cell-mediated granuloma formation and fibrosis around disseminated parasite eggs. This review describes the mechanisms of induction and expression of immunopathology in infected persons and experimental animals. Immunoregulatory mechanisms that modulate the enhanced immune responses and may ameliorate excessive morbidity are discussed.

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“…Patients with blood group A are more susceptible to a severe hepatosplenic form of Schistosomiasis than those with blood group O who developed only milder form of the disease (3,4). Intensity and annual incidence of S. haematobium infection and related organ pathology was significantly higher among children of blood group A and lower among blood group O.…”

Section: Introductionmentioning

confidence: 92%

Filarial infection is resisted differentially by subjects having different blood group phenotypes

Dixit

Pati

Gupta

et al. 2009

Clinical Laboratory Analysis

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This study was aimed to elucidate the relationship between major blood group antigens (BGAs) and susceptibility or resistance to human lymphatic filariasis. A total of 492 human subjects, living in Raipur city of Chhattisgarh, endemic for bancroftian filariasis in Central India, were screened for the presence of Wuchereria bancrofti microfilariae and disease manifestations. The frequency of BGAs was tabulated as a function of the status of filariasis, namely normal (no infection), mf carrier (presence of microfilariae in blood), and elephantiasis (confirmed clinical manifestations). The comparison of ABO phenotype distributions among all the three groups clearly indicated that disease status has a significant relationship with the blood group attributes. The result of chi2 analysis of the frequencies of ABO phenotypes observed in microfilaraemic and elephantiasis groups (observed frequency vs. expected frequency computed based on the distribution of the normal population) revealed that there has been a significant alteration in the distribution of ABO phenotypes in microfilaraemic, but not in elephantiasis, group. The susceptibility to filarial infection was computed as a function of blood group phenotypes in the population. The susceptibility and conditional susceptibility for elephantiasis were the least among the subjects with AB phenotypes. The mechanism of association between filariasis and ABO antigens needs to be further explored to understand how the distribution of BGAs affects susceptibility/resistance to infection.

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A, B, O blood groups and hepatosplenic form of schistosomiasis mansoni (Symmer's fibrosis)

Cited by 25 publications

References 2 publications

The association between multiple intestinal helminth infections and blood group, anaemia and nutritional status in human populations from Dore Bafeno, southern Ethiopia

The association between multiple intestinal helminth infections and blood group, anaemia and nutritional status in human populations from Dore Bafeno, southern Ethiopia

Immunopathology of Schistosoma mansoni infection

Filarial infection is resisted differentially by subjects having different blood group phenotypes

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