A battery-less wireless implant for the continuous monitoring of vascular pressure, flow rate and temperature

Kwon, Kyeongha; Kim, Jong Uk; Zhao, J. Z.; Avila, Raudel; Wang, Heling; Chun, Keum San; Jang, Hokyung; Lee, Kun Hyuck; Kim, Jaehwan; Yoo, Seonggwang; Kang, Youn J.; Kim, Joohee; Lim, Jaeman; Park, Yoonseok; Lü, Wei; Kim, Tae‐il; Banks, Anthony; Rogers, John A.

doi:10.1038/s41551-023-01022-4

Cited by 64 publications

(32 citation statements)

References 22 publications

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“…Flexible electronics with architected 3D configurations can better mimic and conform to the structural forms of natural species with complex spatial geometries, when compared to those in planar device structures. This section reviews diverse 3D forms of flexible electronics manufactured using mechanically-guided assembly methods, including 3D arc-shaped forms, ,,,,,− 3D helical forms, ,,,,,, tubular forms, ,,,− polyhedral forms, ,,− hemispherical forms, ,,,,,,,,,,− conformally wrapping forms ,,,,,,,− and other complex 3D forms, ,,,,,,, through summarizing and discussing the representative functional devices that benefit from their unique structural characteristics.…”

Section: D Device Formsmentioning

confidence: 99%

“…For example, a device in the form of 3D herringbone pattern consisting of two concave arcs (Figure a) was fabricated for bidirectional measurements of flow rates . In particular, a strain sensor was integrated on one of the two arcs (Figure a, left one in the top right panel).…”

Section: D Device Formsmentioning

confidence: 99%

“…3D flexible electronics manufactured through mechanically-guided methods have emerged as promising tools for in vivo monitoring of physiological signals for living organisms, such as tissues and organs. ,,,,,,− For example, 3D piezoelectric microsystems (Figure a) were fabricated for implantable monitoring of muscle activities (e.g., trotting and climbing), providing platforms for in vivo biological interactions without obvious irritations or mechanical constraints . Other 3D forms with high stretchabilities were exploited in wireless skin-compatible electronic sensors, enabling the tracking of spatial motions and the monitoring of electrophysiological signals .…”

Section: Applicationsmentioning

confidence: 99%

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Mechanically-Guided 3D Assembly for Architected Flexible Electronics

Bo,

Xu,

Yang

et al. 2023

Chem. Rev.

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Architected flexible electronic devices with rationally designed 3D geometries have found essential applications in biology, medicine, therapeutics, sensing/imaging, energy, robotics, and daily healthcare. Mechanically-guided 3D assembly methods, exploiting mechanics principles of materials and structures to transform planar electronic devices fabricated using mature semiconductor techniques into 3D architected ones, are promising routes to such architected flexible electronic devices. Here, we comprehensively review mechanically-guided 3D assembly methods for architected flexible electronics. Mainstream methods of mechanically-guided 3D assembly are classified and discussed on the basis of their fundamental deformation modes (i.e., rolling, folding, curving, and buckling). Diverse 3D interconnects and device forms are then summarized, which correspond to the two key components of an architected flexible electronic device. Afterward, structure-induced functionalities are highlighted to provide guidelines for function-driven structural designs of flexible electronics, followed by a collective summary of their resulting applications. Finally, conclusions and outlooks are given, covering routes to achieve extreme deformations and dimensions, inverse design methods, and encapsulation strategies of architected 3D flexible electronics, as well as perspectives on future applications.

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Section: D Device Formsmentioning

confidence: 99%

Section: D Device Formsmentioning

confidence: 99%

Section: Applicationsmentioning

confidence: 99%

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Mechanically-Guided 3D Assembly for Architected Flexible Electronics

Bo,

Xu,

Yang

et al. 2023

Chem. Rev.

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“…The ERG is a diagnostic test that quantifies the electrophysiological activity of various neuronal and non-neuronal cells in the retina under light stimulation. ,− In other words, the ERG measures the electrical potential differences associated with the retina’s response to a light stimulus. It is commonly used in ophthalmology as a standard clinical procedure for the diagnosis of many ocular diseases, such as glaucoma, diabetic retinopathy, RP, and other congenital degenerations. − …”

Section: Diagnostic Sclsmentioning

confidence: 99%

Smart Contact Lenses as Wearable Ophthalmic Devices for Disease Monitoring and Health Management

Seo,

Chung,

Kwon

et al. 2023

Chem. Rev.

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The eye contains a complex network of physiological information and biomarkers for monitoring disease and managing health, and ocular devices can be used to effectively perform point-of-care diagnosis and disease management. This comprehensive review describes the target biomarkers and various diseases, including ophthalmic diseases, metabolic diseases, and neurological diseases, based on the physiological and anatomical background of the eye. This review also includes the recent technologies utilized in eyewearable medical devices and the latest trends in wearable ophthalmic devices, specifically smart contact lenses for the purpose of disease management. After introducing other ocular devices such as the retinal prosthesis, we further discuss the current challenges and potential possibilities of smart contact lenses.

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“…As a complementary, implantable sensors, with small dimensions and flexibility, can be directly implanted on the target tissue and monitor the biomechanical information in situ 15,16 . Various implantable sensors, mostly based on sensitive electronic components or chips, have been designed in advanced research for the monitoring of chronic disease, rehabilitation process, and cardiac rhythm [17][18][19][20][21] .…”

Section: Introductionmentioning

confidence: 99%

An electronics-free implant for continuous and wireless monitoring of internal tissue strains

Zang

Tian

Yang

et al. 2023

Preprint

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Implantable devices for continuous and wireless monitoring of internal tissue strains have gained significant attention in personalized health monitoring. Conventional implantable electronic sensors are small, flexible, and can monitor strains or vibrations in situ. However, electronic sensors still face challenges in biomechanical matching, biodegradability, biocompatibility, and wireless monitoring. Here we present an electronics-free strain sensor based on meta-gels for continuous and wireless monitoring of internal tissue strains. The meta-gel is a two-dimensional phononic crystal hydrogel, composed of periodic air columns in soft hydrogels (~ 18 kPa). The deformation of the meta-gel shifts its ultrasonic band gap, which can be wirelessly detected by an ultrasonic probe outside the skin. The meta-gel sensor is verified to monitor tissue strains on the porcine tendon, wounded tissue, and heart in ex vivo demonstration. Implantations in live pigs further demonstrate the meta-gel’s capability in monitoring tendon stretching, respiratory rhythm, and cardiac rhythm. The meta-gel sensor works stably in the pig during 30 days’ implantation and is observed to undergo almost complete degradation in 12 weeks by ultrasonic imaging.

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A battery-less wireless implant for the continuous monitoring of vascular pressure, flow rate and temperature

Cited by 64 publications

References 22 publications

Mechanically-Guided 3D Assembly for Architected Flexible Electronics

Mechanically-Guided 3D Assembly for Architected Flexible Electronics

Smart Contact Lenses as Wearable Ophthalmic Devices for Disease Monitoring and Health Management

An electronics-free implant for continuous and wireless monitoring of internal tissue strains

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