2004
DOI: 10.1196/annals.1329.002
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A Beginner's Guide to NF‐κB Signaling Pathways

Abstract: Nuclear factor kappaB (NF-kappaB) belongs to a family of heterodimeric transcription factors that play a key role in inflammatory and stress responses as well as in tumor cell resistance to apoptosis. These effects are due to the NF-kappaB-dependent transcription of many proinflammatory and antiapoptotic genes, whose products ensure various cell responses to environmental conditions. The signal transduction pathways leading to NF-kappaB activation are well characterized, and the different steps implicated in t… Show more

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Cited by 96 publications
(88 citation statements)
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References 121 publications
(117 reference statements)
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“…Several NF-Bbinding sites are present in both mouse and human promoters for ⌬N-p63. NF-B can suppress expression of selected target genes (Delhalle et al 2004). Since NF-B activity is induced in keratinocyte differentiation (Seitz et al 1998;van Hogerlinden et al 1999) as well as by Notch activation (Nickoloff et al 2002), an attractive possibility is that suppression of p63 by Notch involves NF-B activation.…”
Section: Discussionmentioning
confidence: 99%
“…Several NF-Bbinding sites are present in both mouse and human promoters for ⌬N-p63. NF-B can suppress expression of selected target genes (Delhalle et al 2004). Since NF-B activity is induced in keratinocyte differentiation (Seitz et al 1998;van Hogerlinden et al 1999) as well as by Notch activation (Nickoloff et al 2002), an attractive possibility is that suppression of p63 by Notch involves NF-B activation.…”
Section: Discussionmentioning
confidence: 99%
“…The latter form is responsible for the prostaglandin synthesis that occurs as part of inflammation and potentiates its progression. COX-2 also promotes angiogenesis (Delhalle et al, 2004). Inhibition of COX-1, however, reduces blood platelet aggregation and causes gastrointestinal distress, among other effects.…”
Section: Proinflammatory Enzymes-nitric Oxide Synthase (Nos) Catalyzementioning
confidence: 99%
“…NF-kB (nuclear factor kB) belongs to a family of heterodimeric transcription factors that play a role in inflammatory and stress responses as well as in tumor cell resistance to apoptosis (Delhalle et al, 2004). Expression of galectin-3 in human T lymphotrophic virus-1 (HTLV-1) infected T-cells was increased by the galectin-3 promoter through interaction with NF-kB .…”
Section: Role Of Galectin-3 In Intrinsic Apoptotic Pathwaysmentioning
confidence: 99%