A Behavioral and Anatomical Analysis of Conditioned Taste Aversion in C57BL/6J and DBA/2J Mice

Glatt, A. Rebecca

doi:10.21007/etd.cghs.2011.0113

Cited by 1 publication

(2 citation statements)

References 101 publications

(267 reference statements)

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“…However, it has also been found that C57BL/6J and DBA/2J mice respond equally to illness induced by LiCl, as evidenced by their similar c‐fos expression levels in the parabrachial nucleus, a brain region associated with learning unpleasant gustatory and visceral information. This data suggests that the strain differences in conditioned taste aversion are not simply due to DBA/2J mice experiencing more illness 48 . Note, however, that the aforementioned study evaluated c‐fos expression following LiCl consumption rather than intraperitoneal injection, so this may explain the lack of sensitivity in the c‐fos measure.…”

Section: Discussionmentioning

confidence: 95%

“…This data suggests that the strain differences in conditioned taste aversion are not simply due to DBA/2J mice experiencing more illness. 48 Note, however, that the aforementioned study evaluated c‐fos expression following LiCl consumption rather than intraperitoneal injection, so this may explain the lack of sensitivity in the c‐fos measure. Whatever the source of these differences, our results are by and large in agreement with the preexisting literature.…”

Section: Discussionmentioning

confidence: 98%

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Genetic and environmental influences on one‐trial conditioned context aversion in mice

İlhan

Urcelay

Kışlal

2023

Genes Brain and Behavior

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Anticipatory nausea (AN) is caused by an association between contextual cues and the experience of nausea (the side effects of chemotherapy or radiation treatment) and it develops predominantly in female patients undergoing chemotherapy. Preclinical studies in rodents show that the administration of an illness‐inducing agent in the presence of novel contextual cues can cause conditioned context aversion (CCA) and this has been proposed to model AN. The literature also suggests that brief pre‐exposure to a novel context prior to shock delivery is critical in the development of contextual fear conditioning in rodents (a phenomenon known as Immediate Shock Deficit), but this has not been assessed in CCA. The aim of present study was to develop a CCA paradigm to assess this in outbred (CD1) and inbred (C57BL/6J) mice and evaluate potential sex differences. The results revealed that a single conditioning trial in which a distinctive context was paired with LiCl‐induced illness was sufficient to elicit a conditioned response in both female and male CD1 outbred mice, but not in C57BL/6J inbred mice. In addition, CCA was facilitated when animals had prior experience with the context. Finally, outbred female mice showed longer and more robust retention of CCA than male mice, which parallels clinical findings. The results indicate the importance of using CD1 outbred mice as an animal model of AN as well as examining sex differences in the CCA paradigm. Similar findings in humans encourage the future use of this novel CCA preclinical mouse model.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 98%