A Bench to Bedside View of Uremic Toxins

Vanholder, Raymond; Baurmeister, U.; Brunet, Philippe; Cohen, Gerald; Glorieux, Griet; Jankowski, Joachim

doi:10.1681/asn.2007121377

Cited by 313 publications

(246 citation statements)

References 76 publications

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“…There was a higher mass removal by the renal route during the CAPD episode, however. PDI important finding, as it has been well established that uremic toxicity does not come from urea or creatinine, but rather from other substances, such as middle molecules and protein-bound solutes (18,19). Previous studies analyzing solute clearance in APD vs CAPD (20,21) all had a cross-sectional observational design so it could not be excluded that inter-individual, e.g.…”

Section: Discussionmentioning

confidence: 99%

Removal of Different Classes of Uremic Toxins in APD vs CAPD: A Randomized Cross-Over Study

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Removal of Different Classes of Uremic Toxins in APD vs CAPD: A Randomized Cross-Over Study

et al. 2015

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“…They have been classiied from the EuTox in difer groups according to their size and molecular weight [34]. A irst group of molecules, around 350 toxins, is composed of small uremic toxins with molecular weight below 500 Da.…”

Section: Bpa In Chronic Kidney Diseasementioning

confidence: 99%

Bisphenol A in Chronic Kidney Disease

Palladino¹,

Sereni²

2017

Bisphenol a Exposure and Health Risks

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Several types of medical devices are produced using polycarbonate (PC) polymer. Unfortunately, these medical devices produced using PC could contain and release Bisphenol A (BPA) residual in routinely use. Published evidence on BPA in dialysis or Chronic Kidney patients (CKD) is scarce and limited to the observation of increased blood BPA levels. Increased serum BPA with decreasing renal function was observed in a smaller study of 32 CKD patients, suggesting that BPA may accumulate. Recently a crossover study evaluated the impact of the choice of dialyzer (BPA-free versus BPAcontaining) on serum and intracellular BPA levels and on inlammation and oxidative stress markers. Currently, BPA is still considered, from regulatory agencies, safe enough in the general population, despite several red lags, as it is readily excreted in the urine. However, patients in End Stage Renal Disease (ESRD) are unable to excrete BPA in their urine, leading to BPA accumulation. Repeated loading of BPA during hemodialysis with BPA-containing membranes may aggravate the problem due to migration of BPA from dialyzers to the blood of patients. In contrast, some recent studies on the chronic use of BPA-free dialyzers, results in decreased BPA levels.

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“…2 -microglobulin, by high-flux hemodialysis is associated with a lower mortality by infectious disease (Cheung et al 2008). An increased removal of middle-sized molecules could also have positive effects of the cardiovascular system (Vanholder et al 2001;Vanholder et al 2008). In a Cochrane database review by Rabindranath et al in 2006, the authors were unable to demonstrate a significant advantage with convective therapies over low-flux hemodialysis with regard to clinical outcomes such as mortality, dialysis-related hypotension and hospitalization (Rabindranath et al 2006).…”

Section: Patients On Hemodialysismentioning

confidence: 99%

Leukocyte Function in High-Flux Hemodialysis

Olsson¹

2011

Progress in Hemodialysis - From Emergent Biotechnology to Clinical Practice

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A Bench to Bedside View of Uremic Toxins

Cited by 313 publications

References 76 publications

Removal of Different Classes of Uremic Toxins in APD vs CAPD: A Randomized Cross-Over Study

Removal of Different Classes of Uremic Toxins in APD vs CAPD: A Randomized Cross-Over Study

Bisphenol A in Chronic Kidney Disease

Leukocyte Function in High-Flux Hemodialysis

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