A benzothiazole-based fluorescent probe for hypochlorous acid detection and imaging in living cells

Nguyen, Khac Hong; Hao, Yuanqiang; Zeng, Ke; Fan, Shengnan; Li, Fen; Yuan, Suke; Ding, Xuejing; Xu, Maotian; Liu, You‐Nian

doi:10.1016/j.saa.2018.03.055

Cited by 51 publications

(10 citation statements)

References 46 publications

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“…Therefore, the development of reliable analytical methods for monitoring HClO has attracted a great deal of attention [108,109]. Based on the unique characteristics of HClO, acting as both a potent oxidant and a good chlorination agent, various reaction-based organic fluorescent probes has been reported for selective sensing of HClO [110,111,112,113,114,115,116,117]. Until now, several examples of MOF-based chemodosimeters for luminescent detection of HClO have been presented.…”

Section: Mof-based Chemodosimeters For Other Redox-active Biomolecmentioning

confidence: 99%

Recent Progress in Metal–Organic Framework (MOF) Based Luminescent Chemodosimeters

et al. 2019

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Metal–organic frameworks (MOFs), as a class of crystalline hybrid architectures, consist of metal ions and organic ligands and have displayed great potential in luminescent sensing applications due to their tunable structures and unique photophysical properties. Until now, many studies have been reported on the development of MOF-based luminescent sensors, which can be classified into two major categories: MOF chemosensors based on reversible host–guest interactions and MOF chemodosimeters based on the irreversible reactions between targets with a probe. In this review, we summarize the recently developed luminescent MOF-based chemodosimeters for various analytes, including H2S, HClO, biothiols, fluoride ions, redox-active biomolecules, Hg2+, and CN−. In addition, some remaining challenges and future perspectives in this area are also discussed.

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Section: Mof-based Chemodosimeters For Other Redox-active Biomolecmentioning

confidence: 99%

Recent Progress in Metal–Organic Framework (MOF) Based Luminescent Chemodosimeters

et al. 2019

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“…To a solution of 2 (0.269 g, 1.0 mmol) in acetonitrile (20 mL) was added 4-(bromomethyl)benzeneboronic acid pinacol ester (0.296 mL, 1.0 mmol) and K2CO3 (0.268 g, 2.0 mmol). 51 The mixture was refluxed for 8 h. Then the resulting white precipitate was collected and further purified over silica gel using dichloromethane/methanol (10/1, v/v) as the eluent to afford the desired probe as a white solid (0.369, 76%). 1…”

Section: Synthesis Of Probementioning

confidence: 99%

“…Notably, recent investigations have demonstrated that the introduction of an electron-withdrawing group into the HBT scaffold can lead to a noticeable red-shift in the emission spectra. [49][50][51][52][53][54] Based on these considerations, we report a ratiometric fluorescent BPO probe (1) by installing arylboronate to a formylated HBT fluorophore. As espected, the developed probe 1 displayed significant red-shift emission bands (λmax = 460 and 546 nm) compared with the previously reproted probe A1.…”

Section: Introductionmentioning

confidence: 99%

A Benzothiazole-based Ratiometric Fluorescent Probe for Benzoyl Peroxide and Its Applications for Living Cells Imaging

Zhao

et al. 2018

ANAL. SCI.

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We present herein a novel ratiometric fluorescent probe (1) for benzoyl peroxide (BPO). Probe 1 was obtained by coupling the recognition unit of arylboronate to a benzothiazole-derived fluorophore. The probe solution is colorless and displays weak blue fluorescence at 460 nm. Upon the addition of BPO, the arylboronate substituent can be removed via oxidation and 1,4-elimination processes. The released fluorophore emits strong yellow-greenish fluorescence at 546 nm. The ratiometric response of the probe is highly selective and sensitive for BPO. The dynamic range was fitted over 1.0-75.0 μM with a detection limit of 0.26 μM. In addition, the probe was applied to quantitative detection of BPO in real samples of wheat flour and an antimicrobial agent. Cellular experiments further demonstrated that probe 1 can be effectively utilized for imaging BPO in living cells.

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“…[6,7,8,9,10,11,12]. In recent years, significant progress was made in this field, and numerous effective fluorescent probes were developed for sensing and imaging applications [13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29]. Thiols (including biothiol, hydrogen sulfide, and thiophenol) are important compounds with some unique properties such as strong nucleophilicity, coordination ability, and reducing capacity [30,31,32,33,34,35,36,37,38,39,40,41,42].…”

Section: Introductionmentioning

confidence: 99%

Recent Progress in the Development of Fluorescent Probes for Thiophenol

et al. 2019

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Thiophenol (PhSH) belongs to a class of highly reactive and toxic aromatic thiols with widespread applications in the chemical industry for preparing pesticides, polymers, and pharmaceuticals. In this review, we comprehensively summarize recent progress in the development of fluorescent probes for detecting and imaging PhSH. These probes are classified according to recognition moieties and are detailed on the basis of their structures and sensing performances. In addition, prospects for future research are also discussed.

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A benzothiazole-based fluorescent probe for hypochlorous acid detection and imaging in living cells

Cited by 51 publications

References 46 publications

Recent Progress in Metal–Organic Framework (MOF) Based Luminescent Chemodosimeters

Recent Progress in Metal–Organic Framework (MOF) Based Luminescent Chemodosimeters

A Benzothiazole-based Ratiometric Fluorescent Probe for Benzoyl Peroxide and Its Applications for Living Cells Imaging

Recent Progress in the Development of Fluorescent Probes for Thiophenol

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