A bibliometric analysis and review of recent researches on TRPM7

Zhang, Shiqi; Zhao, Dongyi; Jia, Wanying; Wang, Yuting; Liang, Hongyue; Liu, Lei; Wang, Wuyang; Yu, Zhiyi; Guo, Feng

doi:10.1080/19336950.2020.1788355

Cited by 21 publications

(21 citation statements)

References 53 publications

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“…Actually, search results in WoS are not presented by author, year, subject and document types like Scopus, but also by institutions and countries [ 32 ], which is convenient for scholars to analyze the distribution of the research organizations. Moreover, WoSCC has been used as a data source in some previous bibliometric studies [ 33 , 34 , 35 , 36 , 37 , 38 ], which further proves its feasibility especially in the natural science domains. The study design was shown in Figure 1 .…”

Section: Methodsmentioning

confidence: 92%

Bibliometric Evaluation of Global Tai Chi Research from 1980–2020

You

Min

Tang

et al. 2021

IJERPH

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While studies on the health benefits of Tai Chi have sprung up over the past four decades, few have engaged in collecting global data, estimating the developing trends, and conducting reviews from the perspective of visualization and bibliometric analysis. This study aimed to provide a summary of the global scientific outputs on Tai Chi research from 1980 to 2020, explore the frontiers, identify cooperation networks, track research trends and highlight emerging hotspots. Relevant publications were downloaded from the Web of Science Core Collection (WoSCC) database between 1980 and 2020. Bibliometric visualization and comparative analysis of authors, cited authors, journals, co-cited journals, institutions, countries, references, and keywords were systematically conducted using CiteSpace software. A total of 1078 publications satisfied the search criteria, and the trend of annual related publications was generally in an upward trend, although with some fluctuations. China (503) and Harvard University (74) were the most prolific country and institution, respectively. Most of the related researches were published in the journals with a focus on sport sciences, alternative medicine, geriatrics gerontology, and rehabilitation. Our results indicated that the current concerns and difficulties of Tai Chi research are “Intervention method”, “Targeted therapy”, “Applicable population”, “Risk factors”, and “Research quality”. The frontiers and promising domains of Tai Chi exercise in the health science field are preventions and rehabilitations of “Fall risk”, “Cardiorespiratory related disease”, “Stroke”, “Parkinson’s disease”, and “Depression”, which should receive more attention in the future.

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Section: Methodsmentioning

confidence: 92%

Bibliometric Evaluation of Global Tai Chi Research from 1980–2020

You

Min

Tang

et al. 2021

IJERPH

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“…This hypothesis is reinforced by the fact that an overexpression and/or activation of the Mg chanzyme channel, the transient receptor potential cation channel, subfamily M, member 7 (TRPM7), has been found in numerous cancers 17 – 24 . Based on these studies, therapeutic strategies with anti TRPM7 drugs have been designed in cancer patients 17 , 23 , 24 .…”

Section: Introductionmentioning

confidence: 99%

Low serum magnesium concentration is associated with the presence of viable hepatocellular carcinoma tissue in cirrhotic patients

Parisse

Ferri

Persichetti

et al. 2021

Sci Rep

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This study aimed to ascertain, for the first time, whether serum magnesium (Mg) concentration is affected by the presence of hepatocellular carcinoma (HCC). We retrospectively enrolled consecutive cirrhotic patients with a diagnosis of HCC (n = 130) or without subsequent evidence of HCC during surveillance (n = 161). Serum levels of Mg were significantly (P < 0.001) lower in patients with HCC than in those without (median [interquartile range]: 1.80 [1.62–1.90] mg/dl vs. 1.90 [1.72–2.08] mg/dl). On multivariate logistic regression, low serum Mg was associated with the presence of HCC (OR 0.047, 95% CI 0.015–0.164; P < 0.0001), independently from factors that can influence magnesaemia and HCC development. In a subset of 94 patients with HCC, a linear mixed effects model adjusted for confounders showed that serum Mg at diagnosis of HCC was lower than before diagnosis of the tumor (β = 0.117, 95% CI 0.039–0.194, P = 0.0035) and compared to after locoregional treatment of HCC (β = 0.079, 95% CI 0.010–0.149, P = 0.0259), with two thirds of patients experiencing these changes of serum Mg over time. We hypothesize that most HCCs, like other cancers, may be avid for Mg and behave like a Mg trap, disturbing the body’s Mg balance and resulting in lowering of serum Mg levels.

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“…TRPM7 has been cloned and functionally characterized two decades ago [ 1 , 2 , 3 ]. Since then, extensive investigations have been conducted to clarify the molecular and organismal aspects of the TRPM7 function [ 4 ]. The outcome of these studies has been comprehensively discussed in a number of recent review articles [ 5 , 6 , 7 , 8 , 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Mapping TRPM7 Function by NS8593

Chubanov¹,

Gudermann²

2020

IJMS

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The transient receptor potential cation channel, subfamily M, member 7 (TRPM7) is a ubiquitously expressed membrane protein, which forms a channel linked to a cytosolic protein kinase. Genetic inactivation of TRPM7 in animal models uncovered the critical role of TRPM7 in early embryonic development, immune responses, and the organismal balance of Zn2+, Mg2+, and Ca2+. TRPM7 emerged as a new therapeutic target because malfunctions of TRPM7 have been associated with anoxic neuronal death, tissue fibrosis, tumour progression, and giant platelet disorder. Recently, several laboratories have identified pharmacological compounds allowing to modulate either channel or kinase activity of TRPM7. Among other small molecules, NS8593 has been defined as a potent negative gating regulator of the TRPM7 channel. Consequently, several groups applied NS8593 to investigate cellular pathways regulated by TRPM7. Here, we summarize the progress in this research area. In particular, two notable milestones have been reached in the assessment of TRPM7 druggability. Firstly, several laboratories demonstrated that NS8593 treatment reliably mirrors prominent phenotypes of cells manipulated by genetic inactivation of TRPM7. Secondly, it has been shown that NS8593 allows us to probe the therapeutic potential of TRPM7 in animal models of human diseases. Collectively, these studies employing NS8593 may serve as a blueprint for the preclinical assessment of TRPM7-targeting drugs.

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A bibliometric analysis and review of recent researches on TRPM7

Cited by 21 publications

References 53 publications

Bibliometric Evaluation of Global Tai Chi Research from 1980–2020

Bibliometric Evaluation of Global Tai Chi Research from 1980–2020

Low serum magnesium concentration is associated with the presence of viable hepatocellular carcinoma tissue in cirrhotic patients

Mapping TRPM7 Function by NS8593

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