A bibliometric and thematic analysis of the trends in the research on ginkgo biloba extract from 1985 to 2022

Ji, Hong-Jian; Zhou, Xiao-Hua; Wu, Hong-Yan; Liu, Hong-Xia; Zhang, Guo-Zhe

doi:10.1016/j.heliyon.2023.e21214

Heliyon

2023

DOI: 10.1016/j.heliyon.2023.e21214

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A bibliometric and thematic analysis of the trends in the research on ginkgo biloba extract from 1985 to 2022

Hong-Jian Ji,

Xiao-Hua Zhou,

Hong-Yan Wu

et al.

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Cited by 5 publications

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An effective and comprehensive optimization strategy for preparing Ginkgo biloba leaf extract enriched in shikimic acid by macroporous resin column chromatography

Zhang,

Gong,

2024

Phytochemical Analysis

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IntroductionPreviously reported preparation methods of Ginkgo biloba leaf extract (EGBL) have mainly focused on the enrichment of flavonoid glycosides (FG) and terpene trilactones (TT), which led to the underutilization of G. biloba leaves (GBL).ObjectivesTo make full use of GBL, in this study, a comprehensive optimization strategy for preparing EGBL by macroporous resin column chromatography was proposed and applied to enrich FG, TT, and shikimic acid (SA) from GBL.MethodologyInitially, the static adsorption and desorption were executed to select suitable resin. Then, the influences of solution pH were investigated by the static and dynamic adsorption. Subsequently, eight process parameters were systematically investigated via a definitive screening design (DSD). After verification experiments, scale‐up enrichment was carried out, investigating the feasibility of the developed strategy for application on an industrial scale.ResultsIt was found that XDA1 was the most appropriate adsorbent for the preparation of EGBL at solution pH 2.0. Furthermore, based on the constraints of the desired quality attributes, the optimized ranges of operating parameters were successfully acquired, and the verification experiments demonstrated the accuracy and reliability of using DSD to investigate the chromatography process for the preparation of EGBL. Finally, magnified experiments were successfully performed, obtaining the EGBL containing 26.54% FG, 8.96% TT, and 10.70% SA, which reached the SA level of EGB761, an international standard EGBL.ConclusionThe present study not only provided an efficient and convenient approach for the preparation of EGBL enriched in SA but also accelerated efforts to high‐value utilization of GBL.

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An effective and comprehensive optimization strategy for preparing Ginkgo biloba leaf extract enriched in shikimic acid by macroporous resin column chromatography

Zhang,

Gong,

2024

Phytochemical Analysis

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Bibliometric analysis of natural language processing using CiteSpace and VOSviewer

Chen,

Tian,

Fang

2025

Natural Language Processing Journal

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Ginkgo biloba extract ameliorates skin fibrosis in a bleomycin-induced mouse model of systemic sclerosis

Lee,

Roh,

Jeong

et al. 2024

Animal Cells and Systems

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A bibliometric and thematic analysis of the trends in the research on ginkgo biloba extract from 1985 to 2022

Cited by 5 publications

References 117 publications

An effective and comprehensive optimization strategy for preparing Ginkgo biloba leaf extract enriched in shikimic acid by macroporous resin column chromatography

An effective and comprehensive optimization strategy for preparing Ginkgo biloba leaf extract enriched in shikimic acid by macroporous resin column chromatography

Bibliometric analysis of natural language processing using CiteSpace and VOSviewer

Ginkgo biloba extract ameliorates skin fibrosis in a bleomycin-induced mouse model of systemic sclerosis

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