A bio-friendly biotin-coupled and azide-functionalized naphthalimide for real-time endogenous hydrogen sulfide analysis in living cells

A human serum albumin-binding-based fluorescent probe for monitoring hydrogen sulfide and bioimaging

“…Recent investigations on fluorescent probes for H 2 S detection are listed in Table S1 † for comparison. [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] Although many probes have been reported to show high sensitivity and selectivity, the measurement span (linear range) values were relatively narrow and limited the practical applications. Herein, the optical capabilities of the probe TPABF-HS were tested, and the linear range was especially focussed on.…”

“…[22][23][24] The reported recognition mechanisms involve azide reduction, copper precipitation and nucleophilic attack on ethers, esters and double bonds, while the selected fluorophores include coumarin, rhodamine, naphthalimide and hemicyanine. [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] For evaluating the practical application of fluorescent probes, the key performance indicators include selectivity (anti-interference), sensitivity (limit of detection (LOD)) and measurement span (linear range).…”

Research Progress on Naphthalimide Fluorescent Probes

“…[71] The excessive generation of HClO may lead to organelles dysfunction, thus, causing diseases like Alzheimer's and Parkinson's diseases. [72] In 2020, Ni et al synthesized the naphthalimide derivative probe NAP-OH (26) for monitoring the dynamic balance of HClO/ClO -(Figure 13). [73] Probe 26 has an on-off-on fluorescence response to ClO -/ascorbic acid (AA).…”

A COX2-targeting cancer-specific fluorescent probe for hydrogen sulfide detection in living cells, Caenorhabditis elegans, and zebrafish

“…11 In this regard, many fluorescent probes specific for H 2 S detection have been developed. [12][13][14][15][16][17][18][19][20][21] In our previous work, a H 2 S triggered twophoton ratiometric fluorescent theranostic probe was also designed and studied in vitro and in vivo. 22 Unfortunately, these probes failed to differentiate tumor tissues from normal tissues, which is a considerable limitation for clinical application.…”