A bio-injectable algin-aminocaproic acid thixogel with tri-stimuli responsiveness

Chejara, Dharmesh R.; Mabrouk, Mostafa; Badhe, Ravindra V.; Mulla, Jameel Ahmed S.; Kumar, Pradeep; Choonara, Yahya E.; Toit, Lisa C. du; Pillay, Viness

doi:10.1016/j.carbpol.2015.08.097

Cited by 14 publications

(11 citation statements)

References 49 publications

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“…In situ gelation may be triggered by external stimuli (i.e. ultra-sonication), as reported by Chejara et al 231 in the synthesis of alginate-based amide conjugate. The presence of amide and acid functional groups at a particular ratio (1:0.5 alginate to aminocaproic acid) facilitated gel formation through inter-molecular hydrogen interactions.…”

Section: Physico-chemical Stimulus-responsive Biopolymersmentioning

confidence: 89%

Biopolymer-based strategies in the design of smart medical devices and artificial organs

et al. 2018

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Advances in regenerative medicine and in modern biomedical therapies are fast evolving and set goals causing an upheaval in the field of materials science. This review discusses recent developments involving the use of biopolymers as smart materials, in terms of material properties and stimulus-responsive behavior, in the presence of environmental physico-chemical changes. An overview on the transformations that can be triggered in natural-based polymeric systems (sol–gel transition, polymer relaxation, cross-linking, and swelling) is presented, with specific focus on the benefits these materials can provide in biomedical applications.

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Section: Physico-chemical Stimulus-responsive Biopolymersmentioning

confidence: 89%

Biopolymer-based strategies in the design of smart medical devices and artificial organs

et al. 2018

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“…For evaluation of inherent thixotropic properties, samples were analyzed using hysteresis loop area technique, applying varying shear rates in the range of 0.1 to 50 s −1 for 600 s. All measurements were undertaken in triplicate. Hysteresis loop, thixotropic area and percentage thixotropic area ( Ar ) were calculated and obtained as described in literature [ 28 ].…”

Section: Methodsmentioning

confidence: 99%

“…This research demonstrates the functionalization of sodium alginate by 4-aminosalicylic acid (4-ASA) via amide bond formation. Several reports have indicated that gelling properties of sodium alginate can be induced via amide formation by adding different amine substrates on its backbone chain [ 26 , 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Evaluation of a Sodium Alginate-4-Aminosalicylic Acid Based Microporous Hydrogel for Potential Viscosupplementation for Joint Injuries and Arthritis-Induced Conditions

et al. 2017

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A microporous hydrogel was developed using sodium alginate (alg) and 4-aminosalicylic acid (4-ASA). The synthesized hydrogel was characterized using various analytical techniques such as Fourier transform infrared spectroscopy (FTIR), Carbon-13 nuclear magnetic resonance (13C-NMR), X-ray powder diffraction (XRD), scanning electron microscopy (SEM), and differential scanning calorimetry (DSC). Additonal carboxyl and hydroxyl functional groups of 4-ASA provided significant lubrication and stress-triggered sol-gel transition to the conjugated hydrogel. In addition, cytotoxicity analysis was undertaken on the conjugated hydrogel using human dermal fibroblast-adult (HDFa) cells, displaying non-toxic characteristics. Drug release profiles displaying 49.6% in the first 8 h and 97.5% within 72 h, similar to the native polymer (42.8% in first 8 h and 90.1% within 72 h). Under applied external stimuli, the modified hydrogel displayed significant gelling properties and structure deformation/recovery behaviour, confirmed using rheological evaluation (viscosity and thixotropic area of 8095.3 mPas and 26.23%, respectively). The modified hydrogel, thus, offers great possibility for designing smart synovial fluids as a biomimetic aqueous lubricant for joint-related injuries and arthritis-induced conditions. In addtion, the combination of thixotropy, non-toxicity, and drug release capabilities enables potential viscosupplementation for clinical application.

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“…Approaches to producing polymers useful for their USCT were to minimise or neutralise ionic groups, maximise the H-bonding capacity, design against hydrolysis and use copolymers with regular repetition. Thus, for example, a tri-stimuli responsive injectable algin-aminocaproic acid thixogel that formed a sol on heating was recently reported by Chejara [74]. Maji presents a study of l -serine-based zwitterionic polymers with a UCST that is relevant for biomedical use, although the low pH would appear to be a potential problem in tissues for a depot dose [75].…”

Section: Thermosensitivity Thermoresponsiveness and Phase Transitmentioning

confidence: 99%

Thermoresponsive Gels

Taylor

Tomlins

Sahota

2017

Gels

146

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Thermoresponsive gelling materials constructed from natural and synthetic polymers can be used to provide triggered action and therefore customised products such as drug delivery and regenerative medicine types as well as for other industries. Some materials give Arrhenius-type viscosity changes based on coil to globule transitions. Others produce more counterintuitive responses to temperature change because of agglomeration induced by enthalpic or entropic drivers. Extensive covalent crosslinking superimposes complexity of response and the upper and lower critical solution temperatures can translate to critical volume temperatures for these swellable but insoluble gels. Their structure and volume response confer advantages for actuation though they lack robustness. Dynamic covalent bonding has created an intermediate category where shape moulding and self-healing variants are useful for several platforms. Developing synthesis methodology-for example, Reversible Addition Fragmentation chain Transfer (RAFT) and Atomic Transfer Radical Polymerisation (ATRP)-provides an almost infinite range of materials that can be used for many of these gelling systems. For those that self-assemble into micelle systems that can gel, the upper and lower critical solution temperatures (UCST and LCST) are analogous to those for simpler dispersible polymers. However, the tuned hydrophobic-hydrophilic balance plus the introduction of additional pH-sensitivity and, for instance, thermochromic response, open the potential for coupled mechanisms to create complex drug targeting effects at the cellular level.

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A bio-injectable algin-aminocaproic acid thixogel with tri-stimuli responsiveness

Cited by 14 publications

References 49 publications

Biopolymer-based strategies in the design of smart medical devices and artificial organs

Biopolymer-based strategies in the design of smart medical devices and artificial organs

Synthesis and Evaluation of a Sodium Alginate-4-Aminosalicylic Acid Based Microporous Hydrogel for Potential Viscosupplementation for Joint Injuries and Arthritis-Induced Conditions

Thermoresponsive Gels

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