A Bioactive Alkaloid from the Flowers of Trollius chinensis

Cai, Shao Qing; Wang, Ru Feng; Yang, Xiu Wei; Mei, Chao; Li, Jian Nong; Shoyama, Yukihiro

doi:10.3987/com-04-10062

Cited by 69 publications

(10 citation statements)

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“…It exhibits antibacterial activity against respiratory bacteria such as Staphylococcus aureus , Streptococcus pneumoniae and Klebsiella pneumoniae , and antiviral activity against influenza virus A and B [12, 13]. Recently, our pilot experiment showed that trolline significantly induced HSC apoptosis.…”

Section: Introductionmentioning

confidence: 99%

Trolline Ameliorates Liver Fibrosis by Inhibiting the NF-κB Pathway, Promoting HSC Apoptosis and Suppressing Autophagy

Bai¹,

Huang²,

Nie³

et al. 2017

Cell Physiol Biochem

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Background/Aims: Previous studies have shown that trolline possesses various forms of pharmacological activity, including antibacterial and antiviral potency. The present paper addressed the putative hepatoprotective effects of trolline. Methods: Rats received 2 ml/kg CCl₄ (mixed 1: 1 in peanut oil) intragastrically twice a week for 8 weeks to induce hepatic fibrosis. The animals were then treated with trolline for additional 4 weeks. Liver pathology and collagen accumulation were observed by hematoxylin-eosin and Masson’s trichrome staining, respectively. Serum transaminase activity and collagen-related indicator level were determined by commercially available kits. NF-κB pathway activation was also examined. Moreover, the effects of trolline on hepatic stellate cell (HSC-T6) apoptosis, mitochondrial membrane potential (MMP), and autophagy were assessed. Results: Trolline significantly alleviated CCl₄-induced liver injury and notably reduced the accumulation of collagen in liver tissues. Trolline treatment also markedly decreased inflammatory cytokines levels by inhibiting the NF-κB pathway. Trolline strongly inhibited HSC-T6 activation and notably induced cell apoptosis by modulating the Bax/Bcl-2 ratio, caspase activity, and MMP. Moreover, trolline significantly inhibited HSC-T6 autophagy, as evidenced by the decrease in the formation of autophagic vacuoles and the number of autophagosomes, by regulating the expression levles of LC3, Beclin-1, P62, Atg 5 and 7. Conclusion: Our study demonstrates that trolline ameliorates liver fibrosis, possibly by inhibiting the NF-κB pathway, promoting HSCs apoptosis and suppressing autophagy.

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Section: Introductionmentioning

confidence: 99%

Trolline Ameliorates Liver Fibrosis by Inhibiting the NF-κB Pathway, Promoting HSC Apoptosis and Suppressing Autophagy

Bai¹,

Huang²,

Nie³

et al. 2017

Cell Physiol Biochem

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“…Lamellarins isolated from marine invertebrates [6] are inhibitors for HIV-1 integrase and also have immuno modulatory activity [7,8]. Trolline has inhibitory activity against Gram-negative and Gram-positive bacteria [9], also as free radical scavenger in rat brain [10]. Organic chemists have been continuously interested in the development of methods for the synthesis of pyrrolo [2,1-a]isoquinolines and related ring systems [11][12][13][14][15], while medicinal chemists have also been interested in making related compounds for biological screening and drug development [16,17].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of pyrrolidinedione-fused hexahydropyrrolo[2,1-a]isoquinolines via three-component [3 + 2] cycloaddition followed by one-pot N-allylation and intramolecular Heck reactions

Meng

Zhang

et al. 2020

Beilstein J. Org. Chem.

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Two kinds of [3 + 2] cycloaddition intermediates generated from the three-component reactions of 2-bromobenzaldehydes and maleimides with amino esters or amino acids were used for a one-pot N-allylation and intramolecular Heck reactions to form pyrrolidinedione-fused hexahydropyrrolo[2,1-a]isoquinolines. The multicomponent reaction was combined with one-pot reactions to make a synthetic method with good pot, atom and step economy. MeCN was used as a preferable green solvent for the reactions.

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“…Lamellarins isolated from marine invertebrates [6] are inhibitors for HIV-1 integrase and also have immuno modulatory activity [7,8]. Trolline has inhibitory activity for Gram-negative andpositive bacteria [9], also as free radical scavenger in rat brain [10]. Organic chemists have contentiously interested in the development of methods for the synthesis of pyrrolo [2,1a]isoquinolines and related ring systems [11][12][13][14][15], while medicinal chemists have also interested in making related compounds for biological screening and drug development [16,17].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of pyrrolidinedione-fused hexahydropyrrolo[2,1-a]isoquinolines via three-component [3+2] cycloaddition followed by one-pot N-allylation and intramolecular Heck reactions

Ma¹,

Meng²,

Zhang³

et al. 2020

Preprint

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Two kinds of [3+2] cycloadditions intermediates generated from the three-component reactions of 2-bromobenzaldehydes and maleimides with amino esters or amino acids were used for one-pot N-allylation and intramolecular Heck reactions to form pyrrolidinedione-fused hexahydropyrrolo[2,1-a]isoquinolines. The multicomponrnt reaction was combined with one-pot reactions to make the synthetic method with good pot, atom and step economy. MeCN was used as a preferable green solvent for the reactions.

show abstract

A Bioactive Alkaloid from the Flowers of Trollius chinensis

Cited by 69 publications

References 1 publication

Trolline Ameliorates Liver Fibrosis by Inhibiting the NF-κB Pathway, Promoting HSC Apoptosis and Suppressing Autophagy

Trolline Ameliorates Liver Fibrosis by Inhibiting the NF-κB Pathway, Promoting HSC Apoptosis and Suppressing Autophagy

Synthesis of pyrrolidinedione-fused hexahydropyrrolo[2,1-a]isoquinolines via three-component [3 + 2] cycloaddition followed by one-pot N-allylation and intramolecular Heck reactions

Synthesis of pyrrolidinedione-fused hexahydropyrrolo[2,1-a]isoquinolines via three-component [3+2] cycloaddition followed by one-pot N-allylation and intramolecular Heck reactions

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