A biobank perspective on use of tissue samples donated by trial participants

Speirs, Valerie; Cox, Angela; Chelala, Claude; James, Jacqueline; Adams, Richard; Jones, J. Louise

doi:10.1016/s1470-2045(22)00186-3

Cited by 2 publications

(2 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, the biobanks that store tissue samples work predominantly in the cancer research field. Finally, it is important to note that several developed countries have not instituted national tissue biobanks [ 110 , 111 , 112 ].…”

Section: Discussionmentioning

confidence: 99%

miRNA Dysregulation in Cardiovascular Diseases: Current Opinion and Future Perspectives

Sessa

Salerno

Esposito

et al. 2023

IJMS

View full text Add to dashboard Cite

MicroRNAs (miRNAs), small noncoding RNAs, are post-transcriptional gene regulators that can promote the degradation or decay of coding mRNAs, regulating protein synthesis. Many experimental studies have contributed to clarifying the functions of several miRNAs involved in regulatory processes at the cardiac level, playing a pivotal role in cardiovascular disease (CVD). This review aims to provide an up-to-date overview, with a focus on the past 5 years, of experimental studies on human samples to present a clear background of the latest advances to summarize the current knowledge and future perspectives. SCOPUS and Web of Science were searched using the following keywords: (miRNA or microRNA) AND (cardiovascular diseases); AND (myocardial infarction); AND (heart damage); AND (heart failure), including studies published from 1 January 2018 to 31 December 2022. After an accurate evaluation, 59 articles were included in the present systematic review. While it is clear that miRNAs are powerful gene regulators, all the underlying mechanisms remain unclear. The need for up-to-date data always justifies the enormous amount of scientific work to increasingly highlight their pathways. Given the importance of CVDs, miRNAs could be important both as diagnostic and therapeutic (theranostic) tools. In this context, the discovery of “TheranoMIRNAs” could be decisive in the near future. The definition of well-setout studies is necessary to provide further evidence in this challenging field.

show abstract

Section: Discussionmentioning

confidence: 99%

miRNA Dysregulation in Cardiovascular Diseases: Current Opinion and Future Perspectives

Sessa

Salerno

Esposito

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…Experimental studies performed on human samples can provide direct links between miRNAs and their molecular targets; nevertheless, several important considerations should be taken into account. First of all, these studies are not error-free, and they require well-trained personnel; moreover, they are expensive (particularly when more than one miRNA is tested) in terms of both time and consumable costs [ 8 , 9 , 10 ]. The experimental protocols that could be applied to in vivo studies to analyze the miRNA targetome are summarized in Figure 1 .…”

Section: Introductionmentioning

confidence: 99%

New Insight into Mechanisms of Cardiovascular Diseases: An Integrative Analysis Approach to Identify TheranoMiRNAs

Sessa

Salerno

Esposito

et al. 2023

IJMS

View full text Add to dashboard Cite

MiRNAs regulate both physiological and pathological heart functions. Altered expression of miRNAs is associated with cardiovascular diseases (CVDs), making miRNAs attractive therapeutic strategies for the diagnosis and treatment of heart diseases. A recent publication defined, for the first time, the term theranoMiRNA, meaning the miRNAs that may be used both for diagnosis and treatment. The use of in silico tools may be considered fundamental for these purposes, clarifying several molecular aspects, suggesting future directions for in vivo studies. This study aims to explore different bioinformatic tools in order to clarify miRNA interactions with candidate genes, demonstrating the need to use a computational approach when establishing the most probable associations between miRNAs and target genes. This study focused on the functions of miR-133a-3p, miR-21-5p, miR-499a-5p, miR-1-3p, and miR-126-3p, providing an up-to-date overview, and suggests future lines of research in the identification of theranoMiRNAs related to CVDs. Based on the results of the present study, we elucidated the molecular mechanisms that could be linked between miRNAs and CVDs, confirming that these miRNAs play an active role in the genesis and development of heart damage. Given that CVDs are the leading cause of death in the world, the identification of theranoMiRNAs is crucial, hence the need for a definition of in vivo studies in order to obtain further evidence in this challenging field of research.

show abstract

A biobank perspective on use of tissue samples donated by trial participants

Cited by 2 publications

References 2 publications

miRNA Dysregulation in Cardiovascular Diseases: Current Opinion and Future Perspectives

miRNA Dysregulation in Cardiovascular Diseases: Current Opinion and Future Perspectives

New Insight into Mechanisms of Cardiovascular Diseases: An Integrative Analysis Approach to Identify TheranoMiRNAs

Contact Info

Product

Resources

About