A Biochemical Evaluation on Inflammatory Markers after Ureteroscopic Lithotripsy

Aydın, İbrahim; Aydın, Fevzi Nuri; Ağıllı, Mehmet

doi:10.1155/2014/795839

Cited by 2 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Endothelial damage may increase the risk of infection, while muscle contractions alone are insufficient to produce this effect. Therefore, it is crucial to identify factors and sources associated with increased IL-6 production [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Inflammatory Parameters Following Extracorporeal Shock Wave Lithotripsy (ESWL) and Ureteroscopy for the Treatment of Proximal Ureteral Stones

Kovačević Prstojević,

Hasanbegović,

Alić

et al. 2024

Cureus

View full text Add to dashboard Cite

Introduction Inflammation can arise as a consequence of both extracorporeal shock wave lithotripsy (ESWL) and ureteroscopy (URS) treatments. Alterations in inflammatory parameters may serve as indicators of kidney injuries and the ensuing inflammation. This study aims to investigate the effects of ESWL and URS procedures on inflammatory parameters for proximal ureteral stone treatment. Materials and methods A prospective interventional study comprised 120 patients with confirmed stones measuring less than 10 mm in the upper half of the proximal ureter. These patients were randomly assigned to either the ESWL or URS treatment groups. Laboratory analyses encompassed interleukin-6 (IL-6), leukocyte count, fibrinogen levels, and erythrocyte sedimentation rate (ESR), which were assessed prior to the intervention, on the first postoperative day, and six months later. IL-6 levels in the serum were determined using a chemiluminescence immunoassay (CLIA). Results There was no significant difference in IL-6 levels between pre-intervention and the first post-intervention day in patients treated with ESWL (1.8 (1.4-2.59) pg/mL vs. 2.33 (1.22-3.19) pg/mL). However, for patients treated with URS, the pre-intervention IL-6 value was 2.9 (1.9-3.34) pg/mL, and it increased significantly to 7.1 (3.85-28.07) pg/mL on the first post-intervention day (p<0.001). On the first post-intervention day, levels of IL-6, CRP, leukocyte count, and ESR were significantly higher in patients treated with URS compared to ESWL (p<0.001; p<0.001; p=0.03; p=0.03, respectively). Conclusion Our research findings suggest that monitoring IL-6 levels can offer valuable insights into the degree of inflammation and tissue damage during and following observed procedures, particularly among patients undergoing URS, even within the initial days post-procedure.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of Inflammatory Parameters Following Extracorporeal Shock Wave Lithotripsy (ESWL) and Ureteroscopy for the Treatment of Proximal Ureteral Stones

Kovačević Prstojević,

Hasanbegović,

Alić

et al. 2024

Cureus

View full text Add to dashboard Cite

show abstract

“…Aydin et al in their letter to the editor commented that urolithiasis causes elevation of IL-6 through two distinct mechanisms: (a) a mechanical one as stones cause direct damage to the endothelium and (b) in response to smooth contraction during renal or ureteral colic [ 4 ].…”

mentioning

confidence: 99%

Comment on “A Biochemical Evaluation on Inflammatory Markers after Ureteroscopic Lithotripsy”

Sountoulides

Bantis

2014

International Scholarly Research Notices

View full text Add to dashboard Cite

A Biochemical Evaluation on Inflammatory Markers after Ureteroscopic Lithotripsy

Cited by 2 publications

References 5 publications

Evaluation of Inflammatory Parameters Following Extracorporeal Shock Wave Lithotripsy (ESWL) and Ureteroscopy for the Treatment of Proximal Ureteral Stones

Evaluation of Inflammatory Parameters Following Extracorporeal Shock Wave Lithotripsy (ESWL) and Ureteroscopy for the Treatment of Proximal Ureteral Stones

Comment on “A Biochemical Evaluation on Inflammatory Markers after Ureteroscopic Lithotripsy”

Contact Info

Product

Resources

About