A biomimetic adipocyte mesenchymal stem cell membrane-encapsulated drug delivery system for the treatment of rheumatoid arthritis

Gu, Chaoyu; Yang, Shaoying; Liu, Xuesong; Jin, Yi; Ye, Yu; Lu, Liangjing

doi:10.1007/s12274-023-5877-6

Cited by 7 publications

(2 citation statements)

References 39 publications

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“…MSC and nanoparticle complex have also been used for the treatment of rheumatoid arthritis (RA) and developed a drug delivery system of MSC membrane-encapsulated PLGA. Gu et al [ 74 ] coated the adipose-derived MSC (ADSC) membrane on PLGA and then loaded with tacrolimus (FK506). This newly developed nanosystem was able to inhibit inflammation by enhancing the anti-inflammatory effect of tacrolimus and also enhancing the expression of anti-inflammatory factors while decreasing the expression of pro-inflammatory factors.…”

Section: Stem Cell Nanotechnology Applications As Drug Delivery Systemsmentioning

confidence: 99%

Frontiers of stem cell engineering for nanotechnology-mediated drug delivery systems

Yeşilkır Baydar,

Ay,

Cakir Koc

2024

ADMET DMPK

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Background and purpose: Cell biology approaches have gained a successful integration, development and application of nanotechnology with stem cell engineering and have led to the emergence of a new interdisciplinary field known as stem cell nanotechnology (SCN). Recent studies showed the potential and the advancement of developments for SCN applications in drug delivery systems. Cancer, neurodegenerative, muscle and blood diseases, cell and gene therapies, and tissue engineering and regenerative medicine applications are the important targets of SCN. Experimental approach: In this overview, we searched the literature using the common online websites for research and read the open access, full-text available articles since 2013. Key results: The studies vary according to the type of disease they targeted and the strategies they proposed, whether diagnostic or therapeutic. In addition to the use of stem cells, the utilisation of their membranes, secretomes, exosomes and extracellular vesicles with an appropriate nanotechnology strategy is also an aspect of the research. Conclusion: This brief overview of stem cell nanotechnology over the last ten years aims to provide insight into the frontiers of stem cell engineering for nanotechnology-mediated drug delivery systems.

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Section: Stem Cell Nanotechnology Applications As Drug Delivery Systemsmentioning

confidence: 99%

Frontiers of stem cell engineering for nanotechnology-mediated drug delivery systems

Yeşilkır Baydar,

Ay,

Cakir Koc

2024

ADMET DMPK

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“…In this way, the adipocyte mesenchymal stem cell membrane (ADSC) loaded with NPs are used for treatment for rheumatic arthritis (RA), which is a chronic and inflammatory autoimmune disease. The in vitro and in vivo studies revealed that pro-inflammatory factors, such as IL-1β, IL-6, and tumor necrosis factor-α decreased, and the anti-inflammatory factor (IL-10) increased without causes of any adverse effects [ 100 ].…”

Section: Other Natural Sources Derived Materials In Drug Delivery Sys...mentioning

confidence: 99%

Drug Delivery Application of Functional Nanomaterials Synthesized Using Natural Sources

Veerapandian

Ramasundaram

Peter

et al. 2023

JFB

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Nanomaterials (NMs) synthesized from natural sources have been attracting greater attention, due to their intrinsic advantages including biocompatibility, stimuli-responsive property, nontoxicity, cost-effectiveness, and non-immunogenic characteristics in the biological environment. Among various biomedical applications, a breakthrough has been achieved in the development of drug delivery systems (DDS). Biocompatibility is necessary for treating a disease safely without any adverse effects. Some components in DDS respond to the physiological environment, such as pH, temperature, and functional group at the target, which facilitates targeted drug release. NM-based DDS is being applied for treating cancer, arthritis, cardiovascular diseases, and dermal and ophthalmic diseases. Metal nanomaterials and carbon quantum dots are synthesized and stabilized using functional molecules extracted from natural sources. Polymers, mucilage and gums, exosomes, and molecules with biological activities are directly derived from natural sources. In DDS, these functional components have been used as drug carriers, imaging agents, targeting moieties, and super disintegrants. Plant extracts, biowaste, biomass, and microorganisms have been used as the natural source for obtaining these NMs. This review highlights the natural sources, synthesis, and application of metallic materials, polymeric materials, carbon dots, mucilage and gums, and exosomes in DDS. Aside from that, challenges and future perspectives on using natural resources for DDS are also discussed.

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Photoresponsive Multirole Nanoweapon Camouflaged by Hybrid Cell Membrane Vesicles for Efficient Antibacterial Therapy of Pseudomonas aeruginosa‐Infected Pneumonia and Wound

Liu,

Tang,

Yin

et al. 2024

Advanced Science

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Exploring effective antibacterial approaches for targeted treatment of pathogenic bacterial infections with reduced drug resistance is of great significance. Combinational treatment modality that leverages different therapeutic components can improve the overall effectiveness and minimize adverse effects, thus displaying considerable potential against bacterial infections. Herein, red blood cell membrane fuses with macrophage membrane to develop hybrid cell membrane shell, which further camouflages around drug‐loaded liposome to fabricate biomimetic liposome (AB@LRM) for precise antibacterial therapy. Specifically, photoactive agent black phosphorus quantum dots (BPQDs) and classical antibiotics amikacin (AM) are loaded in AB@LRM to accurately target the inflammatory sites through the guidance of macrophage membrane and long residence capability of red blood cell membrane, eventually exerting efficacious antibacterial activities. Besides, due to the excellent photothermal and photodynamic properties, BPQDs act as an efficient antibacterial agent when exposed to near‐infrared laser irradiation, dramatically increasing the sensitivity of bacteria to antibiotics. Consequently, the synergistic sterilizing effect produced by AB@LRM further restricts bacterial resistance. Upon laser irradiation, AB@LRM shows superior anti‐inflammatory and antibacterial properties in models of P. aeruginosa‐infected pneumonia and wounds. Hence, this light‐activatable antibacterial nanoplatform with good biocompatibility presents great potential to advance the clinical development in the treatment of bacterial infections.

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A biomimetic adipocyte mesenchymal stem cell membrane-encapsulated drug delivery system for the treatment of rheumatoid arthritis

Cited by 7 publications

References 39 publications

Frontiers of stem cell engineering for nanotechnology-mediated drug delivery systems

Frontiers of stem cell engineering for nanotechnology-mediated drug delivery systems

Drug Delivery Application of Functional Nanomaterials Synthesized Using Natural Sources

Photoresponsive Multirole Nanoweapon Camouflaged by Hybrid Cell Membrane Vesicles for Efficient Antibacterial Therapy of Pseudomonas aeruginosa‐Infected Pneumonia and Wound

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