A biomimetic potentiometric sensor based on molecularly imprinted polymer for the determination of memantine in tablets

Abstract

Memantine hydrochloride is one of the first novel class medications for treatment of Alzheimer's disease. In this work, a biomimetic potentiometric sensor, based on a non-covalent imprinted polymer, was fabricated for the recognition and determination of memantine in pure drug and tablet pharmaceutical form. The molecularly imprinted polymer was synthesized by precipitation polymerization, using memantine hydrochloride as a template molecule, methacrylic acid as a functional monomer, and ethylene glycol dimethacrylate as a cross-linking agent. The sensor was developed by dispersing the memantine imprinted polymer particles in dibutyl sebacate plasticizer and embedding in poly(vinyl chloride) matrix. The wide linear range (10(-5) -10(-1) M), with a near Nernstian response of 57.4 mV/decade, a limit of detection 6.0 × 10(-6) M, fast response time (~15 s) and a satisfactory long-term stability (4 months) are characterizations of the proposed sensor. The sensor showed a high selectivity and a sensitive response to the template in aqueous system. The standard electrode potentials were determined at different temperatures and used to calculate the isothermal coefficient of the electrode. It was used as indicator electrode in potentiometric determination of memantine in pharmaceutical formulations.

Imprinting Technology in Electrochemical Biomimetic Sensors

“…Due to these benefits, several MIP-based sensors have been described with potentiometric transduction [155] for detection of organic and inorganic compounds (Table 2). Murray et al stated for the first time an ion-selective electrode based on a MIP as a biorecognition element with potentiometric transduction [156] for lead ions selective detection.…”

Rapid determination of memantine in human plasma by using nanoring carboxyl‐functionalized paramagnetic molecularly imprinted polymer d‐μ‐SPE and UFLC‐MS/MS

“…Memantine (1‐amino‐3,5‐dimethylad amantane) is a tricyclic amine structurally and pharmacologically related to the antiviral amantadine. It was first synthesized in the 1960s and was found in the 1970s to affect the central nervous system . Memantine (ME) is used to treat Parkinson's disease, movement disorders, and dementia syndrome.…”

“…Molecularly imprinted polymers (MIPs) exhibiting high selectivity and affinity to the predetermined molecule are now seeing a fast‐growing research . Given its application to a wide range of target molecules such as drugs, herbicides, carbohydrates, amino acids, and other biologically and environmentally important molecules, MIPs have become powerful tools for use in certain fields .…”

“…It was first synthesized in the 1960s and was found in the 1970s to affect the central nervous system. [1] Memantine (ME) is used to treat Parkinson's disease, movement disorders, and dementia syndrome. It is well absorbed, with peak plasma concentrations (C max ) ranging from 22 to 46 ng/mL following a single dose of 20 mg. [2] The drug is 45% bound to plasma proteins presenting a distribution volume of approximately 9-11 L/kg, which suggests an extensive distribution into tissues.…”

“…Molecularly imprinted polymers (MIPs) exhibiting high selectivity and affinity to the predetermined molecule are now seeing a fastgrowing research. [1] Given its application to a wide range of target molecules such as drugs, herbicides, carbohydrates, amino acids, and other biologically and environmentally important molecules, MIPs have become powerful tools for use in certain fields. [13][14][15][16][17][18][19][20][21] Meanwhile, magnetic separation has been proven to be a useful tool in several areas, particularly in biomolecule and drug carrier, immobilizer, and separator applications, because of its fast recovery, high efficiency, and low cost.…”