Abstract:The functional reconstruction of periodontal tissue defects remains a clinical challenge due to excessive and prolonged host response to various endogenous and exogenous pro-inflammatory stimuli. Thus, a biomimetic nanoplatform with the capability of modulating inflammatory response in a microenvironment-responsive manner is attractive for regenerative therapy of periodontal tissue. Methods: Herein, a facile and green design of engineered bone graft materials was developed by integrating a biomimetic apatite n… Show more
“…Additionally, the inflammation phase in the initial stage of tissue defects would potentially result in secondary damage to tissue. 73 The transition from inflammation to the anti-inflammation phase was required for establishing an environment for tissue regeneration. 74 As shown in Fig.…”
The repair of mandibular defects remained a challenging problem in the clinic, and the associated infection often hinders the treatment, leading to failure in bone regeneration. Herein, a multifunctional platform...
“…Additionally, the inflammation phase in the initial stage of tissue defects would potentially result in secondary damage to tissue. 73 The transition from inflammation to the anti-inflammation phase was required for establishing an environment for tissue regeneration. 74 As shown in Fig.…”
The repair of mandibular defects remained a challenging problem in the clinic, and the associated infection often hinders the treatment, leading to failure in bone regeneration. Herein, a multifunctional platform...
“…Ostensibly, periodontitis is triggered by bacterial infection, but the source is an imbalance in the ratio of anti-inflammatory to pro-inflammatory phagocytes and a dysregulation of the host's immune inflammatory response. 84 A good therapeutic approach is to achieve anti-inflammatory effects by regulation of chemotaxis and polarization of immune cells. 85 Early treatments were limited to clearing plaque or pathogenic bacteria and did not pay attention to the immune response they triggered.…”
Section: Control Inflammation In Early Periodontitismentioning
This review presents the lastest advances in the treatment of periodontitis with hydrogels. The pathogenic mechanisms of periodontitis are presented, as well as the progress of hydrogel controlling inflammation and tissue reconstruction.
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