A Biosynthesis of Biotin

The Biotin‐Dependent Enzymes

“…5 ) was proposed initially on the basis of nutritional (183)(184)(185)(186)(187)(188)191,193,(195)(196)(197)(198)(199)(200)202) and labeling studies (203,(212)(213)(214)216). An unidentified amino acid vitamer of biotin, labeled during growth on 1,7-14C-pimelate (203) and incorporated into biotin (217), was thought to be the condensation product of pimelate and serine or alanine (215).…”

“…An unidentified amino acid vitamer of biotin, labeled during growth on 1,7-14C-pimelate (203) and incorporated into biotin (217), was thought to be the condensation product of pimelate and serine or alanine (215). Alternatively it has been proposed (188,216) that cysteine was the 3-C condensing partner, although sulfur incorporation concomitant with a 3-C unit has not been demonstrated and a consistent stimulation of biotin biosynthesis by cysteine has not been obtained (187,188,191,196,202 5) has been demonstrated in whole cell preparations (194,201). Dethiobiotin can support the growth of yeast (188,190) and is converted by yeast to a biotin vitamer which is utilized by organisms unable to grow on dethiobiotin (192).…”

Biological Precursors of Biotin and/or Biotin L-Sulfoxide

“…(1)(2)(3)(4). Paine ( 5 ) studied 4 men incidentally exposed to an S M aerosoI while testing protective equipment.…”

Growth Factors and Growth Inhibitors for Micro-organisms

“…diphtheriae is an example of a still earlier stage in the biosynthesis of biotin (Mueller, 1937). Pinielic acid, suberic acid and azelaic acid all increased the synthesis of biotin by Aspergillus niger, while the homologous dicarboxylic acids below pimelic acid did not (Eakin and Eakin, 1942).…”