A Bird's‐Eye View on Deep Eutectic Solvent‐Mediated Multicomponent Synthesis of <i>N</i>‐Heterocycles

S, Lokesh Kumar; Servesh, Anushka; Sriwastav, Yash Kumar; Balasubramanian, Sanjaybala; Tabassum, Sumaiya; Govindaraju, Santhosh

doi:10.1002/slct.202301054

Cited by 18 publications

(4 citation statements)

References 63 publications

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“…26,27 The dopant materials added to PVA alter its electronic properties, allowing for the creation of free charge carriers leading to electrical conductivity. 28,29 Modifying the dopant type and concentration can achieve various levels of conductivity, transforming insulating PVA into valuable semiconducting material for optoelectronic applications. [30][31][32] A novel and promising approach to achieving semiconducting properties in PVA involves the use of a dopant like Ternary Deep Eutectic Solvent (TDES) functionalized activated charcoal (TAC).…”

Section: Introductionmentioning

confidence: 99%

Synergistic fabrication, characterization, and prospective optoelectronic applications of DES grafted activated charcoal dispersed PVA films

Lokesh Kumar,

Binish,

Rajprasad

et al. 2024

Polymers for Advanced Techs

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This study investigates the synthesis, analysis, and utility of films comprising deep eutectic solvent (DES) grafted activated charcoal (AC) within a polyvinyl alcohol (PVA) matrix for optoelectronic device applications. The fabrication process involves the dispersion of DES functionalization AC into the PVA solution, followed by casting onto substrates with controlled drying. Comprehensive characterization encompassing X‐ray diffraction (XRD), scanning electron microscopy (SEM), UV–vis spectroscopy, Fourier‐transform infrared spectroscopy (FTIR), and impedance spectroscopy which discerns the films microstructure, morphology, conductance, band‐gap, and optical traits. The DES grafted AC infusion with variable concentration has significantly influenced optical absorbance and reduced the band gap indicating efficient charge mobility. Furthermore, the impedance analysis has revealed the electrical conduction of the film to be 1.8 × 10−6 Ω−1 m−1. In summary, the dispersion of DES modified AC in the PVA matrix have converted the insulating PVA to a semiconducting polymeric film with reduced band‐gap and increased absorption, which present a propitious avenue for wide array of optoelectronic devices, such as thin film transistors, photovoltaics, LEDs, photodetectors, and many such applications.

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Section: Introductionmentioning

confidence: 99%

Synergistic fabrication, characterization, and prospective optoelectronic applications of DES grafted activated charcoal dispersed PVA films

Lokesh Kumar,

Binish,

Rajprasad

et al. 2024

Polymers for Advanced Techs

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“…12,16,17 Green solvents have a low environmental impact and are generally less toxic than traditional organic solvents. 18 They are an essential part of the principles of green chemistry, which aim to make chemical processes more sustainable. 19,20 Water is the most abundant and environmentally friendly solvent, and water is becoming increasingly used in organic synthesis due to advances in reaction design.…”

Section: Introductionmentioning

confidence: 99%

“…22 They can be designed for specific applications and are often recyclable. Other green solvents commonly used in organic synthetic chemistry are Ethanol, 23 Methanol, Deep Eutectic Solvents (DESs), 18,24 and Supercritical Fluids (SCFs). 25 However, selecting an appropriate green solvent for a synthetic reaction depends on several factors, including the desired reaction conditions, the solubility of the reactants and products, and the environmental impact.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in polyethylene glycol as a dual‐functional agent in heterocycle synthesis: Solvent and catalyst

Servesh,

Lokesh Kumar,

Govindaraju

et al. 2024

Polymers for Advanced Techs

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Reactant solubility, which dictates achievable concentrations, and the stability of reaction intermediates (excited states), solvents modulate the potential energy landscape and influence reaction rates. Consequently, solvent selection is pivotal in optimizing process productivity, economic feasibility, and environmental footprint. At present, organic synthesis pivots around the idea of sustainability. In particular, PEG‐400, a popular solvent and phase transfer catalyst, is considered greener as it can be reused several times without significant loss in its catalytic activity, which checks the box regarding sustainability. This review highlights the emerging potential of Polyethylene Glycol 400 (PEG‐400) as a dual‐threat agent in sustainable organic synthesis. We explore its efficacy as a catalyst, promoting various reactions under mild conditions and often eliminating the need for traditional metal catalysts. Additionally, PEG‐400's role as a green solvent is addressed, emphasizing its biodegradability, low toxicity, and ability to facilitate reactions without hazardous Volatile Organic Compounds (VOCs). The review examines recent research on PEG‐400 mediated reactions, showcasing its effectiveness in diverse transformations, thus exploring the potential of PEG 400 as a facilitator for heterocycle synthesis in both multicomponent reactions and stepwise approaches. It identifies exciting research directions that promise to expand the boundaries of polymer‐based solvents in heterocyclic chemistry.

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“…In recent years, many publications have been devoted to the study of multicomponent reactions (MCRs) [20]. MCRs include reactions where three or more components react.…”

Section: Introductionmentioning

confidence: 99%

Highly diastereoselective synthesis of piperidine-2-one-substituted pyridinium salts from pyridinium ylides, aldehydes, Michael acceptors and ammonium acetate

Vinokurov¹,

Iliyasov²,

Karpenko³

et al. 2023

Preprint

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A novel four-component diastereoselective synthesis of pyridinium salts of piperidin-2-ones is reported. The Michael–Mannich cascade was conducted using Michael acceptors, pyridinium ylides, aromatic aldehydes and ammonium acetate in methanol. It is a convenient approach to the synthesis of 1-((3SR,4RS,6SR)-5,5-dicyano-2-oxo-4,6-diarylpiperidin-3-yl)pyridin-1-ium halogenides with three stereocenters in 48–84% or 1-((3SR,4RS,5RS,6SR)-5-cyano-5-(methoxycarbonyl)-2-oxo-4,6-diarylpiperidin-3-yl)pyridin-1-ium halogenide with four stereocenters in 44–74%. This reaction is highly stereoselective. Only one diastereomer was formed. Ammonium acetate plays a dual role, acting as a base and as a nitrogen source. Structures of the synthesized compounds were confirmed by 1H NMR, 13C NMR, IR and mass spectra. The formation of a single diastereomer was confirmed by singe-crystal X-ray diffraction studies.

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A Bird's‐Eye View on Deep Eutectic Solvent‐Mediated Multicomponent Synthesis of N‐Heterocycles

Cited by 18 publications

References 63 publications

Synergistic fabrication, characterization, and prospective optoelectronic applications of DES grafted activated charcoal dispersed PVA films

Synergistic fabrication, characterization, and prospective optoelectronic applications of DES grafted activated charcoal dispersed PVA films

Recent advances in polyethylene glycol as a dual‐functional agent in heterocycle synthesis: Solvent and catalyst

Highly diastereoselective synthesis of piperidine-2-one-substituted pyridinium salts from pyridinium ylides, aldehydes, Michael acceptors and ammonium acetate

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