A bismuth diethyldithiocarbamate compound induced apoptosis via mitochondria-dependent pathway and suppressed invasion in MCF-7 breast cancer cells

Addressing the gaps in homeostatic mechanisms of copper and copper dithiocarbamate complexes in cancer therapy: a shift from classical platinum-drug mechanisms

“…Furthermore, dithiocarbamates have the potential to activate key proteins involved in cellular mechanisms such as apoptosis, oxidative stress, transcription, and degradation, which now has sparked interest in these molecules as chemotherapeutic agents. 71,171,174,200 As mentioned above, studies on cancer cells have indicated that cancerous cells are far more susceptible to proteosome suppression than normal cells. 201–205 This opens opportunities to design compounds which preferentially bind to proteasomes.…”

“…[167][168][169] Since CS 2 is generally neuropathic, and ethylene thiourea (ETU) (a metabolic product of ethylene bis-dithiocarbamate), is known to have antithyroid and carcinogenic effects, DTC's toxicity can thus be attributed to the entire molecule as well as its degradation products, such as CS 2 and ETU as mentioned above. 170,171 The thiol (SH) plays a significant role in the antioxidant properties of the resulting metal complex, while the disulfide linkages account for their prooxidant properties. 172,173 The varying capabilities for these compounds' intracellular transport and binding to critical conformational and functional components of the cells may cause metabolic changes and physiological alterations.…”

Bioactive Bismuth Compounds: Is Their Toxicity a Barrier to Therapeutic Use?

“…It was found that the different types of bismuth NPs explored led to higher cyto- Some mechanisms of the antitumor action of bismuth compounds have been explored. In this context, bismuth(III) dithiocarbamate complexes induced intrinsic apoptotic pathways in MCF-7 cells, modulated several cancer related genes, and inhibited the NF-κB signaling pathway [70]. Increased phagocytic activity and DNA repair foci were also reported for RAW 264.7 cells exposed to bismuth NPs [71].…”

“…The following supporting information can be downloaded at: https: //www.mdpi.com/article/10.3390/ijms25031600/s1. References [30,35,[44][45][46][47][48][50][51][52][53][54][55][56][57][58][60][61][62][63][65][66][67][68][69][70][72][73][74][75]85] are cited in the supplementary materials.…”

Biological Activities of Bismuth Compounds: An Overview of the New Findings and the Old Challenges Not Yet Overcome

“…Thus, the additional thermodynamic stability in the physiological medium provided by the chelating nature of the ligands has a crucial role in the release rate of Bi ions and, consequently, in the biological action [52]. Still, regarding the role of the ligands in the anticancer activity of bismuth complexes, the presence of lipophilic groups on the molecular structure of the ligand may increase the uptake of target bismuth compounds, thereby enhancing the antiproliferative activity [122], as observed for lipophilic chelating thiol compounds [123][124][125][126]. In addition, the electronic effect and the dipole moment of bismuth-based compounds profoundly influence biological activity: polar compounds generally have better activity against cancer cells than non-polar ones [123,127].…”