2024
DOI: 10.1111/bjh.19925
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A blueprint for pursuing therapeutic interventions and early phase clinical trials in clonal haematopoiesis

Tamanna Haque,
Aditi Shastri,
Pinkal Desai
et al.

Abstract: SummaryThe age‐associated mutational state of clonal haematopoiesis (CH) is linked to multiple adverse health outcomes. As higher risk CH can lead to progressive neoplastic or vascular disease, there is interest in developing clinical trials to mitigate risk associated with CH. Given the high prevalence of CH, data from clinical trials could have broad public health implications for screening and therapy. Thoughtful consideration is needed to design trials that are both clinically relevant and avoid overmedica… Show more

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