A boronic acid-functionalized phthalocyanine with an aggregation-enhanced photodynamic effect for combating antibiotic-resistant bacteria

Abstract

A boronic acid functionalized phthalocyanine displays aggregation-enhanced reactive oxygen species (ROS) generation and excellent photodynamic antibacterial activity.

Turning Photons into Drugs: Phthalocyanine‐Based Photosensitizers as Efficient Photoantimicrobials

“…Formation of self‐assembled photoactive nanodots with aggregation‐enhanced photodynamic effect was recently described by Lee et al [56] . The authors showed that 3‐{ N ‐(4‐boronobenzyl)‐ N , N ‐dimethylammonium} phenoxy‐substituted zinc(II) phthalocyanine can generate approximately 13 times higher ROS than methylene blue through both Type I and Type II photochemical mechanisms.…”

“…Formation of self-assembled photoactive nanodots with aggregation-enhanced photodynamic effect was recently described by Lee et al [56] The authorss howedt hat 3-{N-(4-boronobenzyl)-N,N-dimethylammonium}p henoxy-substituted zinc(II) phthalocyanine can generate approximately 13 times higher ROS than methylene blue throughb oth Type Ia nd Type II photochemical mechanisms. Upon incubation of the PS with representative common and antibiotic-resistant bacterial strains of S. aureus and E. coli as ignificant decrease in bacterial colonies was observed ( % 100 %r eduction when 50 nm of PS and laser irradiation of 0.4 Wcm À2 for 10 min are applied).…”

Phototherapy-based combination strategies for bacterial infection treatment

“…Herein, Yoon et al found that boronic acid-functionalized phthalocyanine (PcN4-BA) displays an uncommon phenomenon, an aggregation-enhanced photodynamic effect. The combination of the ability to form uniform nanostructured self-assemblies in water, highly efficient ROS generation and boronic acid-induced targeting cause PcN4-BA to exhibit excellent performances in antimicrobial photodynamic treatment 145 .…”

A photo-sensitizable phage for multidrug-resistant Acinetobacter baumannii therapy and biofilm ablation

“…[12][13][14] In contrast, organic small molecules have high biosafety owing to easy metabolism in vivo, and they hold great promise in PACT. [15][16][17] However, many of the small molecular photosensitizers (PSs) used in PACT suffer from poor sensitivity due to inefficient generation of ROS and poor selectivity due to the lack of bacterial targeting ability. Thus the aim of this article is to develop a novel PACT agent that possess high selectivity and sensitivity to ght against MRAB and their biolms.…”