A Brain–Kidney Connection: The Delicate Interplay of Brain and Kidney Physiology

Freeman, William D.; Wadei, Hani M.

doi:10.1007/s12028-015-0119-8

Cited by 19 publications

(9 citation statements)

References 9 publications

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“…The incidence of AKI following trauma is reported from 0.098% to 17.3%. [ 7 36 37 38 39 40 ] The incidence of AKI in our study was 3.5%, while in Corral et al . 's study, it was 8%.…”

Section: Discussioncontrasting

confidence: 44%

Non- Neurological Complications after Traumatic Brain Injury: A Prospective Observational Study

Goyal

Hazarika

Khandelwal

et al. 2018

Indian Journal of Critical Care Medicine

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Introduction and Aims:Recognizing and treating nonneurological complications occurring in traumatic brain injury (TBI) patients during intensive care unit (ICU) stay are challenging. The aim is to estimate various nonneurological complications in TBI patients. The secondary aim is to see the effect of these complications on ICU stay, disability, and mortality.Materials and Methods:This was a prospective observational study at the neuro-ICU of a Level-I trauma center. A total of 154 TBI patients were enrolled. The period of the study was from admission to discharge from ICU or demise. Inclusion criteria were patients aged >16 years and patients with severe TBI (Glasgow coma score [GCS] ≤8). Nonneurological complications were frequent in TBI patients.Results:We observed respiratory complications to be the most common (61%). Other complications, in the decreasing order, included dyselectrolytemia (46.1%), cardiovascular (34.4%), coagulopathy (33.1%), sepsis (26%), abdominal complications (17.5%), and acute kidney injury (AKI, 3.9%). The presence of systemic complications except AKI was found to be significantly associated with increased ICU stay. Most of the patients of AKI died early in ICU. Respiratory dysfunction was found to be independently associated with 3.05 times higher risk of worsening clinical condition (disability) (P < 0.018). The presence of cardiovascular complications during ICU stay (4.2 times, P < 0.005), AKI (24.7 times, P < 0.02), coagulopathy (3.13 times, P < 0.047), and GCS <6 (4.2 times, P < 0.006) of TBI was independently associated with significantly increased risk of ICU mortality.Conclusion:TBI patients tend to have poor outcome due to concomitant nonneurological complications. These have significant bearing on ICU stay, disability, and mortality.

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“…The incidence of AKI following trauma is reported from 0.098% to 17.3%. [ 7 36 37 38 39 40 ] The incidence of AKI in our study was 3.5%, while in Corral et al . 's study, it was 8%.…”

Section: Discussioncontrasting

confidence: 44%

Non- Neurological Complications after Traumatic Brain Injury: A Prospective Observational Study

Goyal

Hazarika

Khandelwal

et al. 2018

Indian Journal of Critical Care Medicine

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“…It should be noted that the models of kidney pathology as a constituent of experimental comorbidity are of special interest. Kidneys have certain priority in functional-metabolic supply of the vital organs -the brain, heart, lungs, and liver [6][7][8][9]. Thus, modern directions of cardiac therapy are focused on early detection and optimal correction of pathological interdependent effects, which first of all are associated with kidneys [10][11][12][13].…”

Section: The Aimmentioning

confidence: 99%

Experimental models of kidney diseases to study pathogenetic mechanisms and efficacy of pharmacological correction against the background of comorbid pathology

Seredynska

Filipets

et al. 2019

ZMJ

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Экспериментальные модели заболеваний почек для исследований патогенетических механизмов и эффективности фармакологической коррекции на фоне коморбидной патологии Н. Н. Серединская, Н. Д. Филипец, Е. А. Филипец, К. В. Слободян, А. И. Гоженко Цель работы -освещение современных моделей заболеваний почек, сочетанных с другими патологическими состояниями, для экспериментальных исследований патогенетических механизмов и эффективности фармакологической коррекции.Рассмотрены экспериментальные модели, которые целесообразно использовать для исследования патогенеза и эффективности средств фармакологической коррекции коморбидной патологии. Акцентировано внимание на моделях, воспроизводящих кардиоренальный, гепаторенальный синдром и полиорганное гипоксическое гистогемическое повреждение у лабораторных крыс. Эти модели характеризуются легким моделированием, воспроизведением патогенеза коморбидных заболеваний, наличием острого и хронического периода повреждения, индуцированного антибиотиком доксорубицином или экотоксикантами -сулемой, нитритом натрия, 2,4-динитрофенолом.Выводы. Представленные модели кардиоренального, гепаторенального синдромов и гипоксического повреждения организма являются оптимальными для проведения многоцелевых исследований физиологического, патофизиологического, фармакологического направлений с максимальным приближением результатов к клинико-терапевтическим особенностям коморбидной патологии.The aim of our study is to report about modern models of kidney diseases associated with other pathological conditions for experimental studies of pathogenic mechanisms and efficacy of pharmacological correction.The study deals with experimental models reasonably to be applied in investigation of comorbid pathology pathogenesis and efficacy of its pharmacological correction. The attention is focused on the models of cardio-renal, hepatic-renal syndromes and multiple organ hypoxic histochemical injury simulated in laboratory rats. These models are characterized by easy modeling, simulation of comorbidity pathogenesis, acute and chronic periods of diseases available, induced by the antibiotic Doxorubicin or exotoxins -corrosive sublimate, sodium nitrite, and 2,4-dinitrophenol.Conclusions. The models of cardio-renal, hepatic-renal syndromes and hypoxic histochemical injury of the body are found to be optimal to perform multipurpose studies of physiological, pathophysiological, pharmacological directions with maximal similarity of the results obtained to clinical-therapeutic peculiarities of comorbid pathology.Експериментальні моделі захворювань нирок для досліджень патогенетичних механізмів та ефективності фармакологічної корекції на тлі коморбідної патології Н. М. Серединська, Н. Д. Філіпець, О. О. Філіпець, К. В. Слободян, А. І. Гоженко Мета роботи -висвітлення сучасних моделей захворювань нирок, що поєднані з іншими патологічними станами, для експериментальних досліджень патогенетичних механізмів та ефективності фармакологічної корекції.Розглянуті експериментальні моделі, які доцільно використовувати для дослідження пат...

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“…[2] The incidence of acute renal dysfunction and renal failure after cerebral injury is diversely reported to be ranging from 8% to 23% and 0.5% to 0.8%, respectively, in different studies. [2] Renal problems can occur in various acute cerebral insults such as cerebral ischaemic stroke, subarachnoid haemorrhage, intracerebral haemorrhage, head injury and white matter lesions. [3][4][5]…”

Section: Introductionmentioning

confidence: 99%

Brain injury and the kidney

Kulkarni

2016

Journal of Neuroanaesthesiology and Critical Care

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A Brain–Kidney Connection: The Delicate Interplay of Brain and Kidney Physiology

Cited by 19 publications

References 9 publications

Non- Neurological Complications after Traumatic Brain Injury: A Prospective Observational Study

Non- Neurological Complications after Traumatic Brain Injury: A Prospective Observational Study

Experimental models of kidney diseases to study pathogenetic mechanisms and efficacy of pharmacological correction against the background of comorbid pathology

Brain injury and the kidney

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