A brief review on the strategy of developing SPR-based biosensors for application to the diagnosis of neglected tropical diseases

Souto, Dênio Emanuel Pires; Volpe, Jaqueline; Gonçalves, Conrado de Campos; Ramos, Carlos H.I.; Kubota, Lauro T.

doi:10.1016/j.talanta.2019.120122

Cited by 63 publications

(29 citation statements)

References 72 publications

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“…Due to its label-free, real-time and low-cost detection merits, the surface plasmon sensing technique has been exploited for a range of biosensing applications [28][29][30]. However, for target analytes that have low molecular weights (less than 400 Dalton), plasmonic sensors still face the challenges to compete in terms of detection sensitivity [31].…”

Section: Introductionmentioning

confidence: 99%

Targeted Sub-Attomole Cancer Biomarker Detection Based on Phase Singularity 2D Nanomaterial-Enhanced Plasmonic Biosensor

et al. 2021

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Highlights A zero-reflection-induced phase singularity is achieved through precisely controlling the resonance characteristics using two-dimensional nanomaterials. An atomically thin nano-layer having a high absorption coefficient is exploited to enhance the zero-reflection dip, which has led to the subsequent phase singularity and thus a giant lateral position shift. We have improved the detection limit of low molecular weight molecules by more than three orders of magnitude compared to current state-of-art nanomaterial-enhanced plasmonic sensors. Abstract Detection of small cancer biomarkers with low molecular weight and a low concentration range has always been challenging yet urgent in many clinical applications such as diagnosing early-stage cancer, monitoring treatment and detecting relapse. Here, a highly enhanced plasmonic biosensor that can overcome this challenge is developed using atomically thin two-dimensional phase change nanomaterial. By precisely engineering the configuration with atomically thin materials, the phase singularity has been successfully achieved with a significantly enhanced lateral position shift effect. Based on our knowledge, it is the first experimental demonstration of a lateral position signal change > 340 μm at a sensing interface from all optical techniques. With this enhanced plasmonic effect, the detection limit has been experimentally demonstrated to be 10–15 mol L−1 for TNF-α cancer marker, which has been found in various human diseases including inflammatory diseases and different kinds of cancer. The as-reported novel integration of atomically thin Ge2Sb2Te5 with plasmonic substrate, which results in a phase singularity and thus a giant lateral position shift, enables the detection of cancer markers with low molecular weight at femtomolar level. These results will definitely hold promising potential in biomedical application and clinical diagnostics.

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Section: Introductionmentioning

confidence: 99%

Targeted Sub-Attomole Cancer Biomarker Detection Based on Phase Singularity 2D Nanomaterial-Enhanced Plasmonic Biosensor

et al. 2021

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“…SPR has become a gold standard for biomedical diagnostics including point-ofcare diagnostics. SPR sensing of nucleic acids was reviewed [16], demonstrating the concept of such SPR biosensors in case of nucleic acid detection, the immobilization techniques, fabrication of arrays and quantification strategies in medical diagnostics [158], food safety [159], and environmental monitoring. Improvements in lSPR can be demonstrated in the case of DNA hybridization [160].…”

Section: Fibers and Waveguides Without Structurementioning

confidence: 99%

Critical assessment of relevant methods in the field of biosensors with direct optical detection based on fibers and waveguides using plasmonic, resonance, and interference effects

Gauglitz

2020

Anal Bioanal Chem

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Direct optical detection has proven to be a highly interesting tool in biomolecular interaction analysis to be used in drug discovery, ligand/receptor interactions, environmental analysis, clinical diagnostics, screening of large data volumes in immunology, cancer therapy, or personalized medicine. In this review, the fundamental optical principles and applications are reviewed. Devices are based on concepts such as refractometry, evanescent field, waveguides modes, reflectometry, resonance and/or interference. They are realized in ring resonators; prism couplers; surface plasmon resonance; resonant mirror; Bragg grating; grating couplers; photonic crystals, Mach-Zehnder, Young, Hartman interferometers; backscattering; ellipsometry; or reflectance interferometry. The physical theories of various optical principles have already been reviewed in detail elsewhere and are therefore only cited. This review provides an overall survey on the application of these methods in direct optical biosensing. The "historical" development of the main principles is given to understand the various, and sometimes only slightly modified variations published as "new" methods or the use of a new acronym and commercialization by different companies. Improvement of optics is only one way to increase the quality of biosensors. Additional essential aspects are the surface modification of transducers, immobilization strategies, selection of recognition elements, the influence of non-specific interaction, selectivity, and sensitivity. Furthermore, papers use for reporting minimal amounts of detectable analyte terms such as value of mass, moles, grams, or mol/L which are difficult to compare. Both these essential aspects (i.e., biochemistry and the presentation of LOD values) can be discussed only in brief (but references are provided) in order to prevent the paper from becoming too long. The review will concentrate on a comparison of the optical methods, their application, and the resulting bioanalytical quality.

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“…These comprehensive control actions have allowed significant reductions in the number of new cases of American trypanosomiosis and visceral leishmaniasis in Bangladesh, India and Nepal. In addition, universal screening of Chagas disease has been achieved in blood donors in Latin America [1,8].…”

Section: Advances In the Control Of Tropical Diseasesmentioning

confidence: 99%

The Control of Tropical Diseases is the Health Goal to Achieve

Bastidas¹,

Delgado²,

Delgado³

2019

SJPH

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In the world, one billion people are affected by tropical diseases, mainly people with low economic resources in rural and marginal urban regions. Being an important public health problem, prevention and control have been attempted. Achieving relevant progress in this regard. The objective is to show aspects related to the sanitary approach of tropical diseases. Based on the documentary review of virtual databases based on systematic analysis. The findings were grouped into: advances in the control of tropical diseases; tropical diseases from the prism of human rights; and challenges to consider for the maintenance of the control and extension of the prevention of tropical diseases. It is concluded that despite the complexity of the transmission of tropical diseases, great advances have been made in the control and prevention of some of them; that the principles of participation, non-discrimination and responsibility guarantee the human right to health in tropical diseases; that the progress achieved in the control and prevention of tropical diseases requires international support, consideration of environmental factors, timely health response, professional training, community participation and the promotion of research on the subject.

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A brief review on the strategy of developing SPR-based biosensors for application to the diagnosis of neglected tropical diseases

Cited by 63 publications

References 72 publications

Targeted Sub-Attomole Cancer Biomarker Detection Based on Phase Singularity 2D Nanomaterial-Enhanced Plasmonic Biosensor

Targeted Sub-Attomole Cancer Biomarker Detection Based on Phase Singularity 2D Nanomaterial-Enhanced Plasmonic Biosensor

Critical assessment of relevant methods in the field of biosensors with direct optical detection based on fibers and waveguides using plasmonic, resonance, and interference effects

The Control of Tropical Diseases is the Health Goal to Achieve

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