A Broader Concept of Caplan's Syndrome Related to Rheumatoid Factors

Caplan, Anthony; Payne, Richard E.; Withey, J. L.

doi:10.1136/thx.17.3.205

Cited by 101 publications

(24 citation statements)

References 11 publications

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“…Generally, Th1 dominance is found in patients with generalized autoimmune diseases such as systemic lupus erythematosus (SLE) and systemic scleroderma (SSc) whereas Th2 dominance is present in patients with allergies and organ-specific autoimmune diseases such as Hashimoto's disease and type I diabetes mellitus [38,39]. Thus, SIL might show a tendency towards Th1 dominance as an initial stage of generalized autoimmune disorders, because complicated autoimmune diseases associated with SIL are usually a generalized type such as SSc or rheumatoid arthritis (known as Caplan's syndrome [40][41][42]) [34][35][36][37]. Although IL-2 level did not differ from that in other groups measured, some markers such as soluble IL-2 receptor may be altered in SIL as preautoimmune disease status.…”

Section: Cytokines In Patients With Sil Pp or MM Compared With Healtmentioning

confidence: 99%

Cytokine alteration and speculated immunological pathophysiology in silicosis and asbestos-related diseases

Murakami

Nishimura

Maeda

et al. 2009

Environ Health Prev Med

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This review is partly composed of the presentation ''Cytokine alteration and speculated immunological pathophysiology in silicosis and asbestos-related diseases'' delivered during the symposium ''Biological effects of fibrous and particulate substances and related areas'' organized by the Study Group of Fibrous and Particulate Studies of the Japanese Society of Hygiene and held at the 78th Annual Meeting in Kumamoto, Japan. In this review, we briefly introduce the results of recent immunological analysis using the plasma of silica and asbestos-exposed patients diagnosed with silicosis, pleural plaque, or malignant mesothelioma. Thereafter, experimental background and speculation concerning the immunological pathophysiology of silica and asbestos-exposed patients are discussed.

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Section: Cytokines In Patients With Sil Pp or MM Compared With Healtmentioning

confidence: 99%

Cytokine alteration and speculated immunological pathophysiology in silicosis and asbestos-related diseases

Murakami

Nishimura

Maeda

et al. 2009

Environ Health Prev Med

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“…The typical autoimmune disorders complicated with silicosis include rheumatoid arthritis (well known as Caplan syndrome) [5,6], systemic lupus erythematosus (SLE) [7,8], systemic sclerosis (SSc) [9,10], and anti-neutrophil cytoplasmic antibody (ANCA)-related vasculitis [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Silica exposure and altered regulation of autoimmunity

Lee

Matsuzaki

Kumagai-Τakei

et al. 2014

Environ Health Prev Med

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Silica particles and asbestos fibers, which are known as typical causatives of pneumoconiosis, induce lung fibrosis. Moreover, silicosis patients often complicate with autoimmune diseases, and asbestos-exposed patients suffer from malignant diseases such as pleural mesothelioma and lung cancer. We have been conducting experimental studies to investigate altered regulation of selftolerance caused by silica exposure, including analyses using specimens such as plasma and immunocompetent cells obtained from silicosis patients, as a means of examining the supposition that silica exposure induces molecular and cellular biological alterations of immune cells. These approaches have resulted in the detection of several specific autoantibodies, alterations of CD95/Fas and its related molecules, and evidence of chronic activation of responder T cells and regulatory T cells following silica exposure. In this review, we present details of our investigations as an introduction to scientific approaches examining the immunological effects of environmental and occupational substances.

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“…In addition, R F has been found in coalminers with PMF not characteristic of Caplan's syndrome [Caplan et al, 1962;Wagner and McCormick, 19671. Lindars and Davies [1967] suggested that a gradation might exist between Caplan's syndrome and typical PMF, ie, the lesion formed would depend upon the relative influences of immunological disturbance and dust exposure.…”

Section: Discussionmentioning

confidence: 96%

Autoantibodies in coalminers: Their relationship to the development of progressive massive fibrosis

Boyd¹,

Robertson²,

Davis³

1982

American J Industrial Med

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Sera from 2421 coalminers, representing all the radiological categories of pneumoconiosis, and from 260 healthy blood donors, as controls, were examined for antinuclear factor and rheumatoid factor. Antinuclear factors were present in 21.5% of sera from the controls and in 23.1 % from the coalminers' group. Rheumatoid factor was present in 5.3% of coalminers and as expected occurred particularly in the few men with progressive massive fibrosis who also had rheumatoid disease. The combined prevalence of both factors showed an increase with age at all disease levels and a significant association with pneumoconiosis category only in men older than 60 years. This study provides no evidence that autoantibodies are likely to be of value in detecting men predisposed to the development of massive fibrosis other than those with rheumatoid disease.

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A Broader Concept of Caplan's Syndrome Related to Rheumatoid Factors

Cited by 101 publications

References 11 publications

Cytokine alteration and speculated immunological pathophysiology in silicosis and asbestos-related diseases

Cytokine alteration and speculated immunological pathophysiology in silicosis and asbestos-related diseases

Silica exposure and altered regulation of autoimmunity

Autoantibodies in coalminers: Their relationship to the development of progressive massive fibrosis

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