A C677T mutation in the methylenetetrahydrofolate reductase gene modifies serum cysteine in dialysis patients

Kimura, Hideki; Gejyo, Fumitake; Takeda, Takeshi; Miyazaki, Ryoichi; Yoshida, Haruyoshi

doi:10.1053/ajkd.2000.19085

Cited by 16 publications

(17 citation statements)

References 30 publications

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“…Our finding of a positive correlation between the concentrations of serum folate and plasma cysteine in healthy subjects is in agreement with the observation made in patients on kidney dialysis [16]. However, one study reported a negative relationship between the concentrations of serum folate and plasma cysteine, whereas no relationship was observed in two other studies [17,18].…”

Section: Discussionsupporting

confidence: 92%

Serum Folate Is Significantly Correlated with Plasma Cysteine Concentrations in Healthy Industry Workers

Mansoor¹,

Hervig²,

Stakkestad³

et al. 2011

Ann Nutr Metab

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Background: A low concentration of serum folate is associated with an increased risk of cardiovascular disease. Extracellular cysteine is involved in aging, cancer and cardiovascular disease. The relationship between serum folate and plasma cysteine is poorly understood. Therefore, we investigated this relationship in industry workers, whose health has economic implications. Methods: The concentration of serum folate was determined by the Access ImmunoAssay System Sanofi Pasteur. Plasma cysteine and homocysteine were measured by an ion-pair HPLC method. The concentrations of serum triglycerides were determined by an enzymatic colorimetric method. Results: We detected a positive correlation between the concentration of serum folate and plasma cysteine, whereas the concentration of serum folate was negatively correlated with plasma homocysteine and serum triglycerides. In a multiple regression analysis with adjustment for age, BMI and smoking, serum folate as the dependent variable exhibited a strong relationship with plasma cysteine, and a negative relationship with plasma homocysteine and serum triglycerides. Conclusion: We observed significant correlations between serum folate, plasma cysteine and serum triglyceride concentrations in industry workers, implying that folate may modulate key aspects of the body’s cysteine and lipid metabolism.

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Section: Discussionsupporting

confidence: 92%

Serum Folate Is Significantly Correlated with Plasma Cysteine Concentrations in Healthy Industry Workers

Mansoor¹,

Hervig²,

Stakkestad³

et al. 2011

Ann Nutr Metab

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“…Fundamental design differences in CREED, such as exclusion of those with preexisting cardiovascular disease or on folic acid supplementation, make direct comparisons difficult. The lack of association between C677T genotype of MTHFR and outcomes is consistent with findings of a meta-analysis (21) and a study in Japanese hemodialysis patients (27).…”

Section: Discussionsupporting

confidence: 89%

Randomized Trial of Folic Acid for Prevention of Cardiovascular Events in End-Stage Renal Disease

Wrone

Hornberger

Zehnder

et al. 2004

Journal of the American Society of Nephrology

214

152

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Abstract. High serum total homocysteine (tHcy) is gaining scrutiny as a risk factor for cardiovascular disease in the general population. The relationship between tHcy and mortality and cardiovascular events in patients with end-stage renal disease (ESRD) is unsettled. This randomized trial evaluates the efficacy of high-dose folic acid in preventing events in ESRD. A total of 510 patients on chronic dialysis were randomized to 1, 5, or 15 mg of folic acid contained in a renal multivitamin with a median follow-up of 24 mo. Mortality, cardiovascular events, and homocysteine levels were assessed. There were 189 deaths, and 121 patients experienced at least one cardiovascular event. Composite rates of mortality and cardiovascular events among the folic acid groups did not differ (at 24 mo: 43.7% in 1 mg group, 38.6% in 5 mg group, 47.1% in 15 mg group; log-rank P ϭ 0.47). Unexpectedly, high baseline tHcy was associated with lower event rates. From lowest to highest quartile, event rates at 24 mo were 54.5% for Q1, 41.8% for Q2, 41.2% for Q3, and 34.7% for Q4 (log-rank P ϭ 0.033). In contrast to some studies describing tHcy as a risk factor for mortality and cardiovascular events, this study found a reverse relationship between tHcy and events in ESRD patients. Administration of high-dose folic acid did not affect event rates.

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“…Similar results were obtained in studies of Asians reported by Sun et al [26] and Mtiraoui et al [27]. In studies of Japanese hemodialysis patients, Kimura et al [22] investigated the association between MTHFR C677T and hyperhomocysteinemia, and Morimoto et al [11] investigated MTHFR C677T, hyperhomocysteinemia, and risk of cardiovascular disease, but they did not investigate whether the polymorphism is a risk factor for nephropathy. However, they investigated the genotype frequency of MTHFR C677T in hemodialysis patients, and the frequency of the TT genotype was similar to those reported by Sun et al [26] and Mtiraoui et al [27].…”

Section: Discussionsupporting

confidence: 68%

“…The frequencies of CC, CT, and TT genotypes of MTHFR C677T were 29.5, 43.6, and 26.9 %, respectively, and the frequency of TT genotype was significantly higher than the frequency of that in Japanese hemodialysis patients as reported by Morimoto et al (13.7 %) [11] and Kimura et al (17.4 %) [22] and healthy Japanese (about 15 %) [23,24]. Many studies reported that MTHFR C677T polymorphism is a risk factor for nephropathy, and a significantly high frequency of the TT genotype in nephropathy patients was also detected in a meta-analysis conducted by Yang et al [25].…”

Section: Discussionmentioning

confidence: 59%

“…The energy, protein, potassium, and phosphorus intake sufficiency rates were 97.7, 101.9, 103.6, and 96.7 %, respectively, which met the recommendations of the guidelines, but the salt intake sufficiency rate was 152.6 %, indicating excessive ingestion, and only 12.8 % of patients met the recommendation of less than 6 g/day. [22] (P < 0.05), and this was also significantly higher than that in healthy Japanese (about 15 %) [23,24] (P < 0.05).…”

Section: Habitual Dietary Intakesmentioning

confidence: 73%

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Maintenance of activities of daily living despite risk from genetic polymorphism in hemodialysis patients under nutritional management who survived an average of 30 years

et al. 2015

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A C677T mutation in the methylenetetrahydrofolate reductase gene modifies serum cysteine in dialysis patients

Cited by 16 publications

References 30 publications

Serum Folate Is Significantly Correlated with Plasma Cysteine Concentrations in Healthy Industry Workers

Serum Folate Is Significantly Correlated with Plasma Cysteine Concentrations in Healthy Industry Workers

Randomized Trial of Folic Acid for Prevention of Cardiovascular Events in End-Stage Renal Disease

Maintenance of activities of daily living despite risk from genetic polymorphism in hemodialysis patients under nutritional management who survived an average of 30 years

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