A CaBER computational–experimental rheological study on human sputum

Tabatabaei, Sorour; Jahromi, H.T.; Webster, M.F.; Williams, P. R.; Holder, Alexander; Davies, Gwyneth; Griffin, Lucie S.; Ebden, P; Askill, C.

doi:10.1016/j.jnnfm.2015.03.005

Cited by 10 publications

(12 citation statements)

References 35 publications

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“…The unique structure of the mucin network imparts an extensional character to mucus, which is essential for proper function during physiological processes such as mucociliary clearance (Tabatabaei et al 2015), bolus formation (Burbidge & Le Révérend 2016), and swallowing (Burbidge & Le Révérend 2016). Experimentally, extensional flows are commonly established by stretching a sample between two vertically aligned plates.…”

Section: Spinnabilitymentioning

confidence: 99%

“…Mechanistically, they suggest that, in addition to directly altering the pH of the sample, bicarbonate ions may interact with free or bound calcium to modify the structure and cross-linking of the mucin network and hence the spinnability of the sample (Vijay et al 2015). There is initial experimental and numerical evidence that CaBER measurements of sputum from patients with chronic obstructive pulmonary disease (COPD) may be sensitive enough to serve as biomarkers for stages of active infection (Tabatabaei et al 2015), and Zussman et al (2007) have proposed that the altered extensional rheological properties of saliva measured with CaBER between teenagers and the elderly may be related to the prevalence of different oral and dental conditions within each age group.…”

Section: Spinnabilitymentioning

confidence: 99%

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Mucins and Their Role in Shaping the Functions of Mucus Barriers

Wagner

Wheeler

Ribbeck

2018

Annu. Rev. Cell Dev. Biol.

214

158

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We review what is currently understood about how the structure of the primary solid component of mucus, the glycoprotein mucin, gives rise to the mechanical and biochemical properties of mucus that are required for it to perform its diverse physiological roles. Macroscale processes such as lubrication require mucus of a certain stiffness and spinnability, which are set by structural features of the mucin network, including the identity and density of cross-links and the degree of glycosylation. At the microscale, these same features affect the mechanical environment experienced by small particles and play a crucial role in establishing an interaction-based filter. Finally, mucin glycans are critical for regulating microbial interactions, serving as receptor binding sites for adhesion, as nutrient sources, and as environmental signals. We conclude by discussing how these structural principles can be used in the design of synthetic mucin-mimetic materials and provide suggestions for directions of future work in this field.

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Section: Spinnabilitymentioning

confidence: 99%

Section: Spinnabilitymentioning

confidence: 99%

Mucins and Their Role in Shaping the Functions of Mucus Barriers

Wagner

Wheeler

Ribbeck

2018

Annu. Rev. Cell Dev. Biol.

214

158

View full text Add to dashboard Cite

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“…This was also underlined by Deneuville et al (1997); Lopez-Vidriero and Reid (1978). Although this distinction between mucus seemed no longer considered for several years, more recent studies have confirmed the interest of this observation, using stable/exacerbated distinction rather than visual criteria : Serisier et al (2009) and Tomaiuolo et al (2014) for CF sputum, and Tabatabaei et al (2015) for COPD.…”

Section: Rheology Of Mucus and Non-newtonian Modelsmentioning

confidence: 85%

Modeling Cystic Fibrosis and Mucociliary Clearance

Anne-Archard

Chatelin

Murris-Espin

et al. 2017

Modeling of Microscale Transport in Biological Processes

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International audienceThis chapter considers the investigation of airway clearance efficiency and dysfunction using rheological measurements, modeling and simulations of mucus flows. The work is mainly dedicated to the respiratory epithelium dysfunction subsequently to the consumption of cilia-inhibiting drugs (e.g. nicotine) or viral and/or bacterial infections, and cystic fibrosis, although many respiratory diseases are associated with an altered mucus transport

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“…Our prior studies with kinetic networks/branched molecular structures models such as Phan-Thien/Tanner and pom-pom have shown encouraging results in the areas of flows past objects, filament-stretching, mixing and separating flows and extrusion drawing (Tamaddon-Jahromi 2011a, b;Tabatabaei et al 2015;Echendu et al 2011;Al-Muslimawi et al 2013).…”

mentioning

confidence: 99%

Modified Bautista–Manero (MBM) modelling for hyperbolic contraction–expansion flows

et al. 2015

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In this study, modelling of network-structured material flow is considered through a rounded-corner, hyperbolic 4:1:4 contraction-expansion geometry, under axisymmetric configuration. Three representative constitutive models are adopted to represent networked behaviour and to investigate the flow of wormlike micellar fluids in this context. This includes the modified Bautista-Manero (MBM) model (for base thixotropic properties), some newly proposed micellar models (NM_τ p and NM_T; for advanced thixotropic modelling), and the EPPT model (for contrast against non-thixotropic properties). In this configuration, emphasis is placed upon interpretation of flow behaviour for these constitutive models, against their response in simple rheometrical flows. To best determine the factors that contribute to epd prediction, current findings have also been contrasted against those reported earlier in López-Aguilar et al. (J Non-Newtonian Fluid Mech 204:7-21, 2014), for the counterpart abrupt rounded-corner, axisymmetric 4:1:4 contraction-expansion flow.

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A CaBER computational–experimental rheological study on human sputum

Cited by 10 publications

References 35 publications

Mucins and Their Role in Shaping the Functions of Mucus Barriers

Mucins and Their Role in Shaping the Functions of Mucus Barriers

Modeling Cystic Fibrosis and Mucociliary Clearance

Modified Bautista–Manero (MBM) modelling for hyperbolic contraction–expansion flows

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