A canthin-6-one derivative induces cell death by apoptosis/necroptosis-like with DNA damage in acute myeloid cells

Torquato, Heron Fernandes Vieira; Rodrigues, Manoel T.; Lima, Cristiano de; Júnior, Roberto T. Araujo; Talhati, Fernanda; Dias, Dhébora Albuquerque; Justo, Giselle Z.; Ferreira, Alice Teixeira; Pilli, Ronaldo Aloise; Paredes‐Gamero, Edgar Julian

doi:10.1016/j.biopha.2021.112439

Cited by 9 publications

(5 citation statements)

References 53 publications

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“…Herein, it is found that its derivative, 10-methoxycanthin-6-one (Mtx-C), has the highest anticancer activity in the AML Kasumi-1 cells and KG-1 cells, and the mechanism of inducing cell death was established. Mtx-C could promote the necroptotic pathway, accompanied by an increase in phosphorylation of RIPK3 Ser227 and MLKL Ser358 in Kasumi-1 cells [ 277 ].…”

Section: Targeting Other Rcd Subroutines With Indole Alkaloids In Cancermentioning

confidence: 99%

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Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets

et al. 2022

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Regulated cell death (RCD) is a critical and active process that is controlled by specific signal transduction pathways and can be regulated by genetic signals or drug interventions. Meanwhile, RCD is closely related to the occurrence and therapy of multiple human cancers. Generally, RCD subroutines are the key signals of tumorigenesis, which are contributed to our better understanding of cancer pathogenesis and therapeutics. Indole alkaloids derived from natural sources are well defined for their outstanding biological and pharmacological properties, like vincristine, vinblastine, staurosporine, indirubin, and 3,3′-diindolylmethane, which are currently used in the clinic or under clinical assessment. Moreover, such compounds play a significant role in discovering novel anticancer agents. Thus, here we systemically summarized recent advances in indole alkaloids as anticancer agents by targeting different RCD subroutines, including the classical apoptosis and autophagic cell death signaling pathways as well as the crucial signaling pathways of other RCD subroutines, such as ferroptosis, mitotic catastrophe, necroptosis, and anoikis, in cancer. Moreover, we further discussed the cross talk between different RCD subroutines mediated by indole alkaloids and the combined strategies of multiple agents (e.g., 3,10-dibromofascaplysin combined with olaparib) to exhibit therapeutic potential against various cancers by regulating RCD subroutines. In short, the information provided in this review on the regulation of cell death by indole alkaloids against different targets is expected to be beneficial for the design of novel molecules with greater targeting and biological properties, thereby facilitating the development of new strategies for cancer therapy. Graphic abstract

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Section: Targeting Other Rcd Subroutines With Indole Alkaloids In Cancermentioning

confidence: 99%

“…In addition, Mtx-C can regulate the necroptotic pathway, which is associated with phosphorylation of RIP3 Ser227 and MLKL Ser358. Meanwhile, DNA damage and activation of p38 and JNK MAPKs stress pathways are also involved in Mtx-C-induced cell death [ 277 ].…”

Section: Key Signaling Involved In Cross Talk Between Different Rcd S...mentioning

confidence: 99%

Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets

et al. 2022

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“…The phototoxicity of PYT NPs + NIR was further evaluated in 4T1 cells stained with Annexin V-uorescein isothiocyanate (Annexin V-FITC)/7-aminoactinomycin D (7-AAD) using ow cytometry [30,31]. The Q2 and Q3 represented to late apoptosis cells and the early apoptotic cells, respectively.…”

Section: Resultsmentioning

confidence: 99%

A Novel Polymer Enabled by Polymerized Small Molecule Strategy for Tumor Photothermal and Photodynamic Therapy

Xie,

Wang,

Zeng

et al. 2023

Preprint

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Photothermal therapy (PTT) and photodynamic therapy (PDT) are effective method for tumor treatment. However, the limited variety and quantity of photothermal agents (PTAs) and photosensitizer (PSs) are still major challenges. Moreover, the cell apoptosis mechanism induced by PDT and PTT is still elusive. A fused-ring small molecule acceptor-donor acceptor′ donor-acceptor (A-DA′D-A) type of Y5 (Scheme 1) has a narrow band-gap and strong light absorption. Herein, we used Y5 to polymerize with thiophene unit to obtain polymer PYT based on polymerized small molecule strategy, and PYT nanoparticles (PYT NPs) was prepared via one-step nanoprecipitation strategy with DSPE-PEG2000. PYT NPs had excellent biocompatibility, good photostability, high photothermal conversion efficiency (67%) and reactive oxygen species (ROS) production capacity under 808 nm laser irradiation (PYT NPs + NIR). In intro and in vivo experiments revealed that PYT NPs + NIR had the ability to completely ablate tumor cells. It was demonstrated that cell apoptosis induced by PYT NPs + NIR was closely related to mitochondrial damage. This study provides valuable guidance for constructing high-performance organic PTAs and PSs for tumor treatment.

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“…The phototoxicity of PYT NPs + NIR was further evaluated in 4T1 cells stained with Annexin V-fluorescein isothiocyanate (Annexin V-FITC)/7-aminoactinomycin D (7-AAD) using flow cytometry [50][51][52]. The Q2 and Q3 represented to late apoptosis cells and the early apoptotic cells, respectively.…”

Section: Resultsmentioning

confidence: 99%

A novel polymer enabled by polymerized small molecule strategy for tumor photothermal and photodynamic therapy

Xie,

Wang,

Zeng

et al. 2023

J Nanobiotechnol

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Photothermal therapy (PTT) and photodynamic therapy (PDT) are effective method for tumor treatment. However, the limited variety and quantity of photothermal agents (PTAs) and photosensitizer (PSs) are still major challenges. Moreover, the cell apoptosis mechanism induced by PDT and PTT is still elusive. A fused-ring small molecule acceptor–donor acceptor′ donor–acceptor (A-DA′D-A) type of Y5 (Scheme 1) has a narrow band-gap and strong light absorption. Herein, we used Y5 to polymerize with thiophene unit to obtain polymer PYT based on polymerized small molecule strategy, and PYT nanoparticles (PYT NPs) was prepared via one-step nanoprecipitation strategy with DSPE-PEG2000. PYT NPs had excellent biocompatibility, good photostability, high photothermal conversion efficiency (67%) and reactive oxygen species (ROS) production capacity under 808 nm laser irradiation (PYT NPs + NIR). In vitro and in vivo experiments revealed that PYT NPs + NIR had the ability to completely ablate tumor cells. It was demonstrated that cell apoptosis induced by PYT NPs + NIR was closely related to mitochondrial damage. This study provides valuable guidance for constructing high-performance organic PTAs and PSs for tumor treatment.

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A canthin-6-one derivative induces cell death by apoptosis/necroptosis-like with DNA damage in acute myeloid cells

Cited by 9 publications

References 53 publications

Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets

Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets

A Novel Polymer Enabled by Polymerized Small Molecule Strategy for Tumor Photothermal and Photodynamic Therapy

A novel polymer enabled by polymerized small molecule strategy for tumor photothermal and photodynamic therapy

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