2019
DOI: 10.1016/j.bmcl.2018.11.025
|View full text |Cite
|
Sign up to set email alerts
|

A carbapenem-based fluorescence assay for the screening of metallo-β-lactamase inhibitors

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

2
2
0

Year Published

2019
2019
2024
2024

Publication Types

Select...
4
1

Relationship

1
4

Authors

Journals

citations
Cited by 9 publications
(4 citation statements)
references
References 53 publications
2
2
0
Order By: Relevance
“…KPC-2 and all class B β-lactamases are carbapenemases, which are able to hydrolyze carbapenem antibiotics, as well as most of the other β-lactam antibiotics. As expected, most of these β-lactamases induced significant chemiluminescence signal, except CphA, which is inefficient to hydrolyze cephalosporin antibiotics in spite of high efficiency in the hydrolysis of carbapenem antibiotics , (Figure ).…”
Section: Resultssupporting
confidence: 69%
See 2 more Smart Citations
“…KPC-2 and all class B β-lactamases are carbapenemases, which are able to hydrolyze carbapenem antibiotics, as well as most of the other β-lactam antibiotics. As expected, most of these β-lactamases induced significant chemiluminescence signal, except CphA, which is inefficient to hydrolyze cephalosporin antibiotics in spite of high efficiency in the hydrolysis of carbapenem antibiotics , (Figure ).…”
Section: Resultssupporting
confidence: 69%
“…Moreover, thiophenol-containing β-lactams BL-1 and BL-2 were easily prepared by the substitution of commercially available cephalothin and cefotaxime by PhSNa in PBS, respectively (Scheme S2). Meropenem analogue BL-3 was synthesized from readily available compound 4 after iodination, substitution, and deprotection.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Because of these difficulties,c onsiderable efforts have been invested in searching for new improved methods that are sensitive, specific,r apid, and cost-effective. Following the successful development of b-lactamase-responsive chromogenica nd fluorogenic molecular probes for the identification of bacterial pathogens, [20][21][22][23][24][25][26][27][28][29] scientists are now actively seekings imilar methods for the specific detectiono fc arbapenemasea nd CPOs.…”
Section: Introductionmentioning
confidence: 99%