A carboxymethylcellulose-mediated aqueous colloidal process for building plasmonic–excitonic supramolecular nanoarchitectures based on gold nanoparticles/ZnS quantum emitters for cancer theranostics

Abstract

Despite indisputable advances in recent years, glioblastoma multiforme (GBM) remains one of the most lethal types of brain cancers. Hybrid matter-based nanostructures have exceptional potential as a multimodal tool against...

Bioengineered Carboxymethylcellulose–Peptide Hybrid Nanozyme Cascade for Targeted Intracellular Biocatalytic–Magnetothermal Therapy of Brain Cancer Cells

“…The nanoformulations were designed based on previously published papers by our group [ 20 , 26 ], considering the concentrations of AuNPs and Co-MION (10 mol% Fe 2+ replaced by Co 2+ ) associated with cell viability/toxicity in vitro, as depicted in Table S1 .…”

“…Considering the second portion of the hybrid nanosystems, the hard matter is generally composed of inorganic nanomaterials, including colloidal semiconductor quantum dots (QDs) [ 2 , 7 , 9 ], metallic nanoparticles (e.g., Au, Ag, Pt) [ 6 , 20 ], superparamagnetic iron oxide nanoparticles (SPIONs or MIONs), and other nanosized compounds [ 6 , 19 ]. In this realm, recently, nanozymes—a variety of natural-enzyme-mimicking inorganic nanomaterials—have emerged as an innovative area of research that can play a pivotal role in oncological nanomedicine for diagnosis and therapy [ 21 , 22 , 23 ].…”

Folic acid-functionalized l-cys/ZnS:O nanoparticles for homologous targeting and photodynamic therapy of tumor cells

“…Benefiting from low toxicity and excellent optical stability, ZnS nanoparticles (NPs) can be regarded as a potential bioimaging material. [1][2][3][4][5] As a biological probe, in addition to the features of high luminescence intensity, good hydrophilicity and low toxicity, another important factor of ZnS is its capability for precision. In the early detection of tumors, there were many cases in which ZnS NPs were modified by targeting ligands to achieve tumor cell imaging, [6][7][8][9] such as chitosan, 6 nucleic acids, 7 dopamine, 8 tumor targeted peptides etc.…”

Plasmonic colloidal Au nanoparticles in DMSO: a facile synthesis and characterisation

“…Especially valuable is their ability to support localized surface plasmonic resonances (LSPRs)collective oscillations of free charge carriers, excited by the electric eld of light. 1 The applications of LSPR include surface-enhanced Raman scattering (SERS), [2][3][4][5][6][7] plasmon-enhanced photoluminescence, [8][9][10][11][12] and related optical sensing techniques, 9,[13][14][15][16][17][18][19] bio-imaging, 20 photothermal approaches in anti-tumor therapy, 21,22 plasmonenhanced energy-harvesting, 23 etc. Numerous methods of synthesis of colloidal NPs have been developed so far, 1,2,14, [24][25][26][27] with the facile methods of producing bio-compatible NPs being one of the main research focuses in the community.…”