2007
DOI: 10.1172/jci30804
|View full text |Cite
|
Sign up to set email alerts
|

A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart

Abstract: Marked sarcomere disorganization is a well-documented characteristic of cardiomyocytes in the failing human myocardium. Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC2v), which is involved in the development of human cardiomyopathy, is an important structural protein that affects physiologic cardiac sarcomere formation and heart development. Integrated cDNA expression analysis of failing human myocardia uncovered a novel protein kinase, cardiac-specific myosin light chain kinase (card… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

7
157
1

Year Published

2009
2009
2019
2019

Publication Types

Select...
7
1

Relationship

1
7

Authors

Journals

citations
Cited by 146 publications
(165 citation statements)
references
References 29 publications
7
157
1
Order By: Relevance
“…cRLC mutations associated with hypertrophic cardiomyopathy abolish cRLC phosphorylation in vitro (15), and mice expressing nonphosphorylatable cRLCs show severe cardiac dysfunction (10,16). In the vertebrate heart, cRLCs are phosphorylated almost exclusively by the cardiac isoform of myosin light chain kinase (cMLCK) (17,18), and cMLCK gene ablation leads to severe cardiac hypertrophy (19).…”
mentioning
confidence: 99%
“…cRLC mutations associated with hypertrophic cardiomyopathy abolish cRLC phosphorylation in vitro (15), and mice expressing nonphosphorylatable cRLCs show severe cardiac dysfunction (10,16). In the vertebrate heart, cRLCs are phosphorylated almost exclusively by the cardiac isoform of myosin light chain kinase (cMLCK) (17,18), and cMLCK gene ablation leads to severe cardiac hypertrophy (19).…”
mentioning
confidence: 99%
“…The potential transcription factors regulating downregulated genes were labeled in blue, while transcription factors regulating downregulated genes were labeled in red reassembly (Medjkane et al, 2009). SCIN (scinderin) is a Ca(2+)-dependent actin-severing and -capping protein, might act as a molecular switch in the control of cortical F-actin dynamics during secretion (Seguchi et al, 2007).…”
Section: Discussionmentioning
confidence: 99%
“…• A novel cardiac-specific myosin light chain kinase (cardiac-MLCK) that was identified in failing human myocardium was shown to be required for zebrafish cardiac development, since MO knockdown induced cardiac dilatation and oedema [91].…”
Section: The Genetics Of Cardiovascular Disease 193mentioning
confidence: 99%