A case control study of risk factors and neonatal outcomes of preterm birth

Jiang, Min; Mishu, Miskatul Mustafa; Lü, Dan; Yin, Xianghua

doi:10.1016/j.tjog.2018.10.008

Cited by 72 publications

(78 citation statements)

References 26 publications

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“…Gender-specific vulnerability should also be carefully considered when studying the influence of birth modifications on early development. Indeed, epidemiological studies on perinatal adverse outcomes [60][61][62] or the emergence of psychiatric disorders such as ASD [63], schizophrenia [64,65], and attention deficit hyperactivity disorder [66] have revealed an imbalanced male-tofemale ratio with stronger symptoms in males. However, recent work also revealed that females have their own plethora of deleterious manifestations [67][68][69], warning against the extrapolation of male disease mechanisms to females.…”

Section: Discussionmentioning

confidence: 99%

Alteration in the time and/or mode of delivery differentially modulates early development in mice

2020

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Delivery is a complex biological process involving hormonal and mechanical stimuli that together condition the survival and development of the fetus out of the womb. Accordingly, changes in the time or way of being born are associated with an alteration of fundamental biological functions and hypothesized to promote the emergence of neurodevelopmental disorders. Hence, the steadily rise in preterm birth and cesarean section (CS) delivery rates over the past years has become a worldwide health concern. In our previous work, we reported that even though no long-term autistic-like deficits were observed, mice born preterm by CS presented early transient neuronal and communicative defects. However, understanding if these alterations were due to an early birth combined with CS delivery, or if prematurity solely could lead to a similar outcome remained to be evaluated. Using mice born either at term or preterm by vaginal or CS delivery, we assessed early life ultrasonic vocalizations and the onset of eye opening. We report that alterations in communicative behaviors are finely attuned and specifically affected either by preterm birth or by the association between CS delivery and preterm birth in mice, while delayed onset of eye opening is due to prematurity. Moreover, our work further underlies a gender-dependent vulnerability to changes in the time and/or way of being born with distinct outcomes observed in males and females. Thus, our results shed light on the intricacy of birth alterations and might further explain the disparities reported in epidemiological studies.

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Section: Discussionmentioning

confidence: 99%

Alteration in the time and/or mode of delivery differentially modulates early development in mice

2020

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“…However, some publications have been distinguished from ours [2,16,22]. The risk of preterm birth in girls less than 19-year-old is associated with biological immaturity and low gynecological age [20]; they lead to more common anaemia and genital tract inflammation [2]. In women aged 30 years and older, the higher rates of preterm birth are associated with more common pregnancy complications, as well as changes in anatomy and physiology of the female reproductive system which speed up labor [18].…”

Section: Discussionmentioning

confidence: 85%

“…Obstetric RFs have an important role on the multifactorial etiology of prematurity, as: multiple pregnancies which associated with assist reproductive technologies (ART), breech presentation of the fetus, placenta previa, premature amniotic fluid rupture, inducing labor for medical causes, multiple parity [2,[17][18][19][20][21][22].…”

Section: Discussionmentioning

confidence: 99%

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A Case-Control Study of Obstetric Risk Factors for Low Birth Weights and Preterm Births

Hristova¹,

Simeonova²,

Hinkova³

et al. 2020

SJMPS

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To study the role of the obstetric risk factors for low birth weight and preterm birth. A case-control study was carried out in 2017 at the University Hospital-Pleven; 1212 women in childbirth and 1212 live-born babies after single pregnancies were included in the study. The live-born infants were divided into two groups. The cases included the preterm low-birthweight (PLBW) newborns weighing less than 2500 grams (g). The controls included full-term newborns with normal birth weight (FTNBW). The role of 8 obstetric risk factors (RFs) on PLBW was studied (maternal age, type of birth, amniotic fluid deficiency and congenital abnormalities, maternal pelvic size abnormalities, placental abnormalities, abnormalities of fetal membranes, umbilical cord abnormalities, and presentation of the fetus). The obstetric RFs were significantly associated with PLBW. Risk of PLBW is significantly higher (p=0.001) in breech presentation (exp (β)=6.622), placental abnormalities (exp (β)=5.556), maternal pelvic size abnormalities (exp (β)=4.426) and amniotic fluid deficiency and congenital abnormalities (exp (β)=2.903). The results of that study can be useful for effecting prevention programing of pregnancy and prematurity.

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“…Preterm newborns have an increased risk of short‐term complications affecting multiple organ systems and long‐term consequences such as neurodevelopmental disability, cardiovascular diseases, behavioral problems, childhood asthma, depression and diabetes . Besides, preterm birth causes severe economic and emotional burden, which is also an important issue . In threatened preterm labor, the aim of tocolytic therapy is to gain time by prolonging the pregnancy for 24–48 h for administering antenatal corticosteroids and transferring the patient to a center capable of caring the infant .…”

Section: Introductionmentioning

confidence: 99%

Comparison of the efficacy of the immediate‐release and osmotic push–pull system formulations of nifedipine for tocolysis

İnan

Sayın

Dolgun

et al. 2019

J of Obstet and Gynaecol

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Aim: To compare the immediate-release (IR) and osmotic push-pull system formulations of nifedipine used for tocolysis in prolonging pregnancy, neonatal outcomes and maternal-fetal adverse effects. Methods: We evaluated 140 pregnant women who received the IR (n = 72) and osmotic push-pull system (n = 68) formulations of nifedipine for tocolysis due to threatened preterm labor between 24 0/7 and 33 6/7 weeks of gestation. Groups were compared in terms of efficacy of tocolysis in prolonging pregnancy for more than 48 h, 7 days and up to 37 weeks of gestation, total number of days gained for prolonging pregnancy, delivery weeks, maternal-fetal adverse effects and neonatal outcomes including ventilation support, need for intubation or surfactant, intraventricular hemorrhage, respiratory distress syndrome, necrotizing enterocolitis, admission to neonatal intensive care unit, neonatal death, Apgar scores at the 1st and 5th minutes.Results: There was no significant difference between the two groups in prolonging pregnancy for more than 48 h or 7 days, total number of days gained after tocolysis initiation, delivery weeks, the number of births at 34 0/7 -36 6/7 weeks or after 37 weeks of gestation (P > 0.05). Maternal-fetal adverse effects and neonatal outcomes were similar in both groups (P > 0.05). Conclusion: The efficacy of IR and osmotic push-pull system formulations of nifedipine have similar effects in terms of tocolysis and neonatal outcomes, adverse effects. Osmotic push-pull system formulation of nifedipine may be an alternative medication in tocolytic therapy due to its ease of use and the absence of loading dose necessity.

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A case control study of risk factors and neonatal outcomes of preterm birth

Cited by 72 publications

References 26 publications

Alteration in the time and/or mode of delivery differentially modulates early development in mice

Alteration in the time and/or mode of delivery differentially modulates early development in mice

A Case-Control Study of Obstetric Risk Factors for Low Birth Weights and Preterm Births

Comparison of the efficacy of the immediate‐release and osmotic push–pull system formulations of nifedipine for tocolysis

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