A case-control study of hepatitis B and C virus infection as risk factors for hepatocellular carcinoma in Henan, China

Zhang, Jian Ying; Dai, Min; Xiao, Wang; Lü, Wei; Li, Dongsheng; Zhang, Mei Xi; Wang, Ke Juan; Dai, Li; Han, Sheng; Zhou, Yuan; Zhang, Hui

doi:10.1093/ije/27.4.574

Cited by 72 publications

(64 citation statements)

References 20 publications

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“…A total of 32 case -control studies satisfied the inclusion criteria (Xu et al, 1990;Gong et al, 1993;Zhang et al, 1993Zhang et al, , 1998Ye et al, 1994;Zhou et al, 1994;Fan et al, 1995a, b;Pan et al, 1995;Wang et al, 1996aWang et al, , b, 1999Guo and Yan, 1997;Lu, 1997;Lu and Hou, 1997;Ma et al, 1997;Shen et al, 1997;Yu et al, 1997;Zuo et al, 1997;Dai et al, 1998;Gao et al, 1998;Cui et al, 1999;Li et al, 1999Li et al, , 2002Yang et al, 1999;Zhao et al, 2000;Shi et al, 2001;Su et al, 2002;Wang, 2003;Wu et al, 2003;Zeng et al, 2003;Ding et al, 2004). Their basic characteristics are shown in Table 1.…”

Section: Resultsmentioning

confidence: 99%

A meta-analysis of case–control studies on the combined effect of hepatitis B and C virus infections in causing hepatocellular carcinoma in China

et al. 2005

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We investigated whether concurrent infection by hepatitis B virus (HBV) and hepatitis C virus (HCV) in China, a hyperepidemic area for these infections, was associated with a higher risk of causing hepatocellular carcinoma (HCC) than each infection alone in a metaanalysis in China, 32 case -control studies involving 3201 cases and 4005 controls, identified from a computer-based literature search from 1966 to 2004. The pooled odds ratio and 95% confidence interval (CI) for HBsAg positivity was 14.1 (95% CI: 10.6 -18.8); for anti-HCV/HCV RNA positivity was 4.6 (95% CI: 3.6 -5.9); for HBsAg positivity and anti-HCV/HCV RNA negativity were 15.6 (95% CI: 11.5 -21.3); for HBsAg negativity and anti-HCV/HCV RNA positivity were 8.1 (95% CI: 5.0 -13.0); and positivity for both HBsAg and anti-HCV/HCV RNA was 35.7 (95% CI: 26.2 -48.5). We conclude that HBV and HCV infections are important independent risk factors for HCC in China, and that dual infection by HBV and HCV is associated with a higher risk of causing HCC than each infection alone, suggesting a synergism between HBV and HCV. ). More than 500 000 new cases are currently diagnosed yearly, with an ageadjusted worldwide incidence of 5.5 -14.9 per 100 000 population (Llovet et al, 2003). About 110 000 persons die each year from HCC in China, which accounts for 45% of the deaths from HCC worldwide. China is also a hyperepidemic area for hepatitis B virus (HBV) infection (with an estimated carrier rate exceeding 10% in the general population) and hepatitis C virus (HCV) infection (with a prevalence of anti-HCV 3.1% of in the general population) (Xuezhong et al, 1999). HBV and HCV infections have each been shown to markedly increase the risk of developing HCC. In China, HBV has, for several decades, been the major cause of liver disease (Tang, 2001). Soon after the identification of HCV and the development of testing HCV infection, it has become increasingly evident that chronic HCV infection also plays an important role in chronic hepatic disease including HCC (Yano et al, 1993;Tsai et al, 1994). There have been several meta-analyses of the relation of HBV and HCV infections to HCC in China, but the relation of dual infection to HCC has not received similar attention. In fact, this is not rare in HCC patients and a higher morbidity in HCC patients with dual infection has been reported than in those with one infection (Benvegnu et al, 1994). The main difficulty in evaluating the relationship of dual infection to HCC is the rarity of concurrent infection in subjects without clinically evident liver disease. Only large case -control studies that include people unaffected by chronic liver diseases as controls can allow the interaction to be properly assessed. The aim of this meta-analysis is to assess the interaction between HBV and HCV infections among 32 casecontrol studies of HCC. MATERIALS AND METHODS Data sourcesWe searched the published Chinese literature from 1979 to February 2004 and Medline database from 1966 to February 2004 to identify case -control studies of the...

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Section: Resultsmentioning

confidence: 99%

A meta-analysis of case–control studies on the combined effect of hepatitis B and C virus infections in causing hepatocellular carcinoma in China

et al. 2005

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“…Most of the previous studies from China and other countries demonstrated that hepatitis B virus (HBV) or hepatitis C virus (HCV) infection, dietary exposure to aflatoxin and excessive alcohol consumption were the principal etiological factors for HCC [18][19][20][21][22][23]. The majority of people with HCC will die within 1 year of its detection.…”

Section: Introductionmentioning

confidence: 99%

Antibody detection using tumor-associated antigen mini-array in immunodiagnosing human hepatocellular carcinoma

Zhang

Megliorino

Peng

et al. 2007

Journal of Hepatology

113

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Background/Aims-Previous studies have demonstrated that during transition from chronic liver disease to hepatocellular carcinoma (HCC), autoantibodies can appear which are not detected in the prior pre-malignant conditions. These antibody responses may be stimulated by cellular proteins involved in carcinogenesis. This study determines the prevalence of antibodies to a selected panel of eight tumor-associated antigens (TAAs) in sera from patients with chronic hepatitis, liver cirrhosis and HCC, and considers the possibility and usefulness of antibodies to such a panel of TAAs in differentiating between these conditions. The panel of eight TAAs includes Imp1, p62, Koc, p53, cmyc, cyclin B1, survivin and p16 full-length recombinant proteins.Methods-Enzyme-linked immunosorbent assay (ELISA) was used to detect antibodies against eight selected TAAs in 30 sera from chronic hepatitis, 30 from liver cirrhosis, and 142 from HCC. Positive results were also confirmed by slot blot, Western blotting and immunoprecipitation assay.Results-Antibody frequency to any individual TAA in HCC varied from 9.9%-21.8%. With the successive addition of TAAs to a final total of eight antigens, there was a stepwise increase of positive antibody reactions reaching a frequency of 59.8% with whole cohort of HCC patients. This was significantly higher than the frequency of antibodies in chronic hepatitis (20%), liver cirrhosis (30%) and normal individuals (12.2%).Conclusions-This study demonstrates that malignant transition to HCC is associated with increased autoantibody responses to certain cellular proteins which might have a role in tumorigenesis, and shows that a mini-array of eight TAAs enhanced antibody detection for diagnosis of HCC. More studies in patients with HCC and precursor conditions such as chronic hepatitis, alcoholic hepatitis and liver cirrhosis using enlarged TAA mini-array panels might further improve the sensitivity and specificity of this mode of cancer immunodiagnosis. Its additional usefulness might be in the early detection of cancer in some patients with predisposing conditions.

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“…In neighboring Bulgaria, the percentage of co-infection was 0.68% (16). It is considered that such co-infection can significantly increase the risk for development of hepatocellular carcinoma and it is common in areas with a high prevalence of hepatitis B (17)(18)(19).…”

Section: Discussionmentioning

confidence: 99%

Epidemiological Characteristics of Carrying Viral Hepatitis B Antigen in the Population of the Nišava District

Kostić¹,

Kocić²,

Rančić³

2014

Acta Facultatis Medicae Naissensis

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Summary The aim of this paper was to determine the trend of diseases and epidemiological characteristics of viral antigen carrying of hepatitis B for better implementation of prevention and control of the disease activity. The annual reports, reports of diseases - deaths from infectious diseases, epidemiological survey of the Public Health Institute (IPH) Niš were used as the material. The period from 2002 to 2011 in the Nišava District was considered. A descriptive method was used. HBsAg carrying shows an upward trend (y=15+3.27 x). Most carriers are males (57.27%), live in urban areas (98.16/ 100.000 population), average age 41.92 years old ±SD 18.59, pensioners (22.42%). 54.05% are nephrology patients (almost all retirees under the age of 60 years old). Only 15.76% were hospitalized. The data on the vaccination status are insufficient. In 5.45%, co-infection with hepatitis C virus was found. 63.33% belong to the group of patients for whom there were no data on the mode of transmission. Hemodialysis patients make 16.67%, blood donors 9.39%, 6.36% pregnant women and injecting drug users 1.21%. The upward trend of carrying, the presence of all known risk groups in the population of carrying in the Nišava District points to the need for improved epidemiological surveillance, strict application of protective measures, conducting of statutory vaccination of all categories of people exposed to particular risk of infection as well as continuing education on preventive measures of both population and health care providers.

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A case-control study of hepatitis B and C virus infection as risk factors for hepatocellular carcinoma in Henan, China

Cited by 72 publications

References 20 publications

A meta-analysis of case–control studies on the combined effect of hepatitis B and C virus infections in causing hepatocellular carcinoma in China

A meta-analysis of case–control studies on the combined effect of hepatitis B and C virus infections in causing hepatocellular carcinoma in China

Antibody detection using tumor-associated antigen mini-array in immunodiagnosing human hepatocellular carcinoma

Epidemiological Characteristics of Carrying Viral Hepatitis B Antigen in the Population of the Nišava District

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