A Case-Control Study of Risk Factors in Open Angle Glaucoma

Wilson, M. Roy; Hertzmark, Ellen; Walker, Arthur B. C.; Childs-Shaw, K; Epstein, David L.

doi:10.1001/archopht.1987.01060080068030

Cited by 281 publications

(169 citation statements)

References 27 publications

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“…3 Several risk factors have been evaluated for POAG, including black race, untreated systolic hypertension, current cigarette smoking, family history of glaucoma, diabetes mellitus, and myopia. 4 Elevated IOP was found to be a major risk factor. 5 An interaction between genetic and environmental risk factors is usually assumed to confer the complex disease phenotype.…”

Section: Introductionmentioning

confidence: 45%

Current concepts on primary open-angle glaucoma genetics: a contribution to disease pathophysiology and future treatment

Gemenetzi

Yang

Lotery

2011

Eye

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Section: Introductionmentioning

confidence: 45%

Current concepts on primary open-angle glaucoma genetics: a contribution to disease pathophysiology and future treatment

Gemenetzi

Yang

Lotery

2011

Eye

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“…In this clinical context, baseline routine data are used primarily for assessing the risk of the individual having the disease glaucoma, on the basis of findings from a number of observational, mostly cross-sectional studies. [1][2][3]7,8,31,40,41 As previously discussed conceptually by Drance et al, it is important to distinguish between factors that affect disease occurrence, that is, prevalence or incidence of new cases, and those that affect progression of existing glaucomatous damage. 14 Factors associated with occurrence of glaucoma are important clinically to assist in 'case finding' or detection of disease, and are also of use from a public health perspective for health care service planning.…”

Section: Discussionmentioning

confidence: 99%

“…Exposures included were selected on the basis of association with development of chronic open-angle glaucoma in peer-reviewed literature. [1][2][3][4][5][6][7][8][29][30][31][32][33][34][35][36][37][38][39][40][41][42] Some exposures were 'by patient' while others were 'by eye'. Exposures were either be derived from baseline characteristics, for example, the presence of a or b parapapillary atrophy, or were obtained from sequential measurements made during routine clinical review, such as IOP variation during the study.…”

Section: Risk Factors For Progressive Glaucomatous Visual Field Lossmentioning

confidence: 99%

“…This has resulted in increased knowledge of risk factors for development of glaucoma, [1][2][3][4][5][6][7][8] signs associated with glaucomatous optic nerve damage, characteristics of glaucomatous loss of visual function, [9][10][11][12][13] and consequently optimised decision-making strategies for discrimination between normal individuals and those with POAG. [14][15][16] Once an individual has been diagnosed with POAG, intraocular pressure-lowering treatment is commenced with the aim of preventing or decelerating progressive loss of visual function.…”

Section: Introductionmentioning

confidence: 99%

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Risk factors for progressive visual field loss in primary open angle glaucoma

Spry

Sparrow

Diamond

et al. 2004

Eye

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Purpose The aim of this study was to evaluate routine ophthalmic data to identify clinically useful risk factors for progressive visual field loss in patients with primary openangle glaucoma (POAG) already receiving intraocular pressure-lowering treatments. Methods A retrospective cohort study design was used. Routine ophthalmic data for all subjects were obtained from case records with the knowledge that baseline clinical data had been collected in a standardised manner. Progression was defined according to the AGIS visual field defect scoring system. Variables evaluated as candidate risk factors for progression were assessed by survival analysis. Factors exerting a significant effect on survival were subsequently tested in a Cox proportional hazards model. Results A cohort of 108 eligible POAG patients was followed over an average of 3.6 years, with an average visual field intertest interval of 8 months. The incidence rate of progressive loss among the cohort was 5.4 cases per 100 person years. Increasing age was found to be independently associated with a small but significantly increased risk of glaucomatous visual field defect progression (hazard ratio 1.07, P ¼ 0.022), and a borderline association was also demonstrated with being male (hazard ratio 2.76, P ¼ 0.057). Conclusions This retrospective investigation has provided preliminary information on factors associated with increased risk of progressive glaucomatous visual field loss that may inform clinical care strategies. Lack of concordance with other studies suggests that further prospective investigations are needed if risk stratification strategies are to be employed in caring for patients with chronic open-angle glaucoma.

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“…Recién nacidos y neonatos con patología neonatal. 16 muestras agrupados según las CDM que corresponden a los sistemas corporales. Las enfermedades y trastornos del sistema respiratorio y circulatorio son los más frecuentes motivos de ingreso en los pacientes con GPAA (24 y 22% respectivamente).…”

Section: Análisisunclassified

Factores de riesgo vascular en el glaucoma primario de ángulo abierto

Belzunce

Casellas²

2004

Anales Sis San Navarra

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RESUMENFundamentos. Conocer si los factores de riesgo cardiovascular se distribuyen de modo distinto en pacientes con glaucoma primario de ángulo abierto (GPAA) o en pacientes controles. Cuantificar la prevalencia de estos factores en el GPAA. Analizar la patología concomitante más prevalente en este grupo de pacientes y analizar sus implicaciones en el tratamiento médico del GPAA.Material y Métodos. Estudio observacional transversal sobre población hospitalaria con diagnóstico de GPAA. Se seleccionaron mediante muestreo consecutivo 50 pacientes ingresados en un hospital terciario por cualquier motivo con antecedentes de GPAA y se compararon con un grupo control de 50 pacientes con ingreso hospitalario durante el mismo período y sin diagnóstico de GPAA.Se incluyeron las variables edad, sexo, motivo de ingreso codificado según su grupo relacionado por diagnóstico (GRD) y categoría diagnóstica mayor (CDM), tratamiento del glaucoma, antecedentes personales incluyendo la presencia o no de: accidente cerebrovascular, diabetes, hipertensión arterial, cardiopatía isquémica, fenómeno de Raynaud, hipotensión, dislipemia y tabaquismo.Resultados. Existe una asociación aunque no llega al nivel de significación estadística entre el GPAA y el accidente cerebrovascular (razón de prevalencias=2,16; IC al 95%=1,01-2,20; p=0,074*), la hipotensión arterial (razón de prevalencias=5; intervalo de confianza=1,14-2,63; p=0,092*) y la hipertensión arterial (razón de prevalencias=1,35; p=0,16). Con el tamaño de la muestra no se encontró asociación con el resto de las variables estudiadas.El motivo de ingreso hospitalario más frecuente en este grupo de pacientes es debido a trastornos del sistema respiratorio y circulatorio (24 y 22% respectivamente) siendo la neumonía el GRD más frecuente (10%). En el grupo control: las enfermedades del sistema circulatorio seguidas de las del sistema respiratorio (24 y 16% respectivamente). La reagudización de la enfermedad pulmonar obstructiva crónica (EPOC) es el GRD más frecuente (6%).El factor de riesgo vascular más frecuente en ambos grupos es la hipertensión arterial (54 frente a un 40%) seguido del accidente cerebrovascular (26 frente al 12% del grupo control).El tratamiento médico más utilizado en estos pacientes son los betabloqueantes solos (24,3%) o en asociación (18,9%)Conclusiones. El GPAA está asociado con la enfermedad cerebrovascular y las variaciones de la presión arterial (hiper/hipotensión). Las enfermedades del sistema respiratorio (neumonía y EPOC), circulatorio (insuficiencia cardiaca congestiva-ICC-y cardiopatía isquémica) son la causa de morbilidad más prevalente en este grupo. El tratamiento médico del glaucoma más utilizado son los betabloqueantes que están contraindicados en pacientes con EPOC e ICC.Palabras clave. Glaucoma primario de ángulo abierto. Neuropatía óptica glaucomatosa. Presión intraocular. Isquemia de la cabeza del nervio óptico. ABSTRACTPurpose. To determine whether cardiovascular risk factors distribution differ between primary open-angle glaucoma (POAG) and c...

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A Case-Control Study of Risk Factors in Open Angle Glaucoma

Cited by 281 publications

References 27 publications

Current concepts on primary open-angle glaucoma genetics: a contribution to disease pathophysiology and future treatment

Current concepts on primary open-angle glaucoma genetics: a contribution to disease pathophysiology and future treatment

Risk factors for progressive visual field loss in primary open angle glaucoma

Factores de riesgo vascular en el glaucoma primario de ángulo abierto

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