A Case-Control Study of the Association between Polymorphisms in the Fibrinogen Alpha Chain Gene and Schizophrenia

Rao, Wenwang; Zhou, Na; Zhang, Huiping; Liu, Rui; Zhang, Shangchao; Su, Yingying; Yang, Guang; Ma, Yue; Shi, Jieping; Yu, Yaqin; Yu, Qiong

doi:10.1155/2017/3104180

Cited by 6 publications

(5 citation statements)

References 20 publications

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“…Gender-specific associations between variants of CHGB and SCZ have been revealed in a Korean population by Shin et al [15]. Conversely, a case-control study indicated that there was no significant association between SNPs of FGA and SCZ [19]. …”

Section: Discussionmentioning

confidence: 99%

Association Between Polymorphisms of the Complement 3 Gene and Schizophrenia in a Han Chinese Population

Zhang

Zhou

et al. 2018

Cell Physiol Biochem

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Background/Aims: Schizophrenia is a severe psychiatric disorder, and complement 3 (C3) is closely related to schizophrenia. We investigated the association between C3 polymorphisms and schizophrenia in a Northeast Han Chinese population. Methods: A total of 2240 Chinese people, consisting of 1086 patients with schizophrenia and 1154 healthy controls, were recruited for this study. Ten single nucleotide polymorphisms (SNPs; rs11569562, rs344555, rs2241393, rs2241392, rs11569514, rs445750, rs451760, rs11672613, rs2230205, and rs2250656) in C3 were selected and genotyped. Results: Genotype distribution analysis indicated that rs11569514 was significantly associated with schizophrenia. In the dominant model (AA vs. GG+GA genotypes), we found a significant protective effect for rs344555 against schizophrenia (odds ratio [OR]: 0.72, 95% confidence interval [CI]: 0.53–0.99, P = 0.04). In the codominant model (TT vs. AA), we found a significant risk effect for rs11569514 on schizophrenia (OR: 4.39, 95% CI: 2.06–9.37, P < 0.001). Haplotypes, including TG (rs11569562 and rs344555), TGG (rs11569562-rs344555-rs2241393), AG (rs344555-rs2241393), CGGGT (rs11569562-rs344555-rs2241393-rs2241392-rs11569514), and ACGTG (rs11569514-rs445750-rs451760-rs11672613-rs2230205), showed either a risk or protective role for schizophrenia. Conclusions: SNP rs11569514 in C3 and haplotypes of C3 variants were associated with schizophrenia in a Han Chinese population.

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Section: Discussionmentioning

confidence: 99%

Association Between Polymorphisms of the Complement 3 Gene and Schizophrenia in a Han Chinese Population

Zhang

Zhou

et al. 2018

Cell Physiol Biochem

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“…Our group also studied the association between the fibrinogen alpha chain gene polymorphisms and schizophrenia [11]. Another study also further to demonstrate that relationship between polymorphisms in the fibrinogen alpha chain Gene(FGA) and Schizophrenia [5].…”

Section: Discussionmentioning

confidence: 99%

“…Fibrinopeptide A (FPA) is a product of proteolysis by thrombin of fibrinogen [4]. Now some previous studies using the mass spectrum analysis to prove that fibrinopeptide A (FPA) could be a potential biomarker for schizophrenia diagnosis [5]. MicroRNAs (miRNAs) are single-stranded RNA molecules, consisting of 21-23 nucleotides, which has the function of regulation [6].…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Gene Polymorphism of miRNAs Regulating FGA and Schizophrenia

Cao¹,

Yang²,

Kang³

et al. 2019

Open Access Maced J Med Sci

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AIM: To investigate the relationship between the polymorphism of related gene loci of miRNAs regulated fibrinopeptide A and schizophrenia. Lay the foundation for the aetiology of schizophrenia. METHODS: Adapt to the phase match of sex and age case-control study, a total of 513 Chinese Han patients with schizophrenia were selected as the case group, 513 normal healthy persons as a control group. Obtaining SNPs information of the FGA gene by querying the dbSNP database, and reference HapMap database included SNPs site frequency information for screening. The frequency distributions of SNPs were genotyped by iMLDR® SNP detection technology. Two SNPs (pre-hsa-miR-605rs2043556 T>C, pre-hsa-miR-499a/pre-hsa-miR-499brs4909237 T < C) were analyzed to demonstrate their association with susceptibility to schizophrenia. RESULTS: There were no significant differences between patients and controls in genotype and allele distribution of SNPs(rs2043556 and rs4909237)in the precursor region of hsa-miR-605 and pre-hsa-miR-499a/pre-hsa-miR-499b. Their gene-gene interaction, which suggests that the polymorphisms of miRNA genes might not contribute to schizophrenia susceptibility in the Han Chinese population. CONCLUSION: No significant difference existed between schizophrenic patients and controls in SNP (rs2043556 and rs4909237) in the precursor region of hsa-miR-605 and pre-hsa-miR-499a/pre-hsa-miR-499b. There may not regulate FGA gene expression. Thus, hsa-miR-605 and pre-hsa-miR-499a/pre-hsa-miR-499b may not influence the risks of schizophrenia.

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“…A total of 445 SCZ patients were recruited from the Sixth Hospital of Changchun City and Siping Psychiatric Hospital. At least two independent experienced psychiatrists diagnosed the patients according to the tenth edition of International Classification of Diseases diagnostic criteria (ICD-10) [12]. Birthdate- and gender- matched control subjects were recruited from the Changchun Municipal Center for Disease Control and Prevention, and 515 healthy controls were free from mental illness.…”

Section: Methodsmentioning

confidence: 99%

CACNA1C Polymorphism (rs2283291) Is Associated with Schizophrenia in Chinese Males: A Case-Control Study

Zhu

Kang

et al. 2019

Disease Markers

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Recent research has shown that prenatal famine exposure may be one of the risk factors for schizophrenia and that people born in famine years may be at an increased risk of schizophrenia due to alteration of the DNA methylation of genes. In this study, the association of rs2283291/rs4648635 and the incidence of schizophrenia and prenatal famine exposure at the genetic level were investigated to provide clues to the pathogenesis of schizophrenia. A total of 960 participants were recruited, comprising 473 prenatal famine-exposed individuals (225 patients and 248 controls) and 487 prenatal non-famine-exposed individuals (220 patients and 267 controls). The association of prenatal famine, schizophrenia, and their interaction with DNA methylation levels was analyzed using SPSS and GMDR software. Gender stratification analysis revealed a significant association between the rs2283291 genotype and schizophrenia in male patients (P=0.017), and difference still existed after correction by the Bonferroni method. It was also found that an increasing risk of schizophrenia was associated with rs2283291 in males (OR: 1.62, 95% CI: 1.13-2.33, P=0.0086, AIC=669.7) in an overdominant model. The results of gene-environment interaction and gene-gene interaction revealed no association with the risk of schizophrenia. This study reported for the first time that rs2283291 was associated with schizophrenia in Chinese males.

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A Case-Control Study of the Association between Polymorphisms in the Fibrinogen Alpha Chain Gene and Schizophrenia

Cited by 6 publications

References 20 publications

Association Between Polymorphisms of the Complement 3 Gene and Schizophrenia in a Han Chinese Population

Association Between Polymorphisms of the Complement 3 Gene and Schizophrenia in a Han Chinese Population

The Relationship between Gene Polymorphism of miRNAs Regulating FGA and Schizophrenia

CACNA1C Polymorphism (rs2283291) Is Associated with Schizophrenia in Chinese Males: A Case-Control Study

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