A case-control study of topical and supplemental fluoride use and osteosarcoma risk

Hayes, Catherine; Douglass, Chester W.; Kim, Frances M.; Burgard, Sheila; Couper, David; Simón, Margarida; Gebhardt, Mark C.; Scarborough, Mark T.; Gitelis, Steven; Eċkardt, Jeffrey J.; Neff, James R.; McGuire, Michael H.; Anderson, Harald

doi:10.1016/j.adaj.2021.01.010

Cited by 2 publications

(2 citation statements)

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“…Sodium fluoride (NaF) via the diet, oral administration, and/or drinking water [99] is very effective for preventing demineralization particularly when optimal levels of the ion are present in ECF at the time the outer layers of enamel are formed (say age 2-10years) [101][102][103]. Despite broad-based opposition to fluoridation for many years, there are no scientific risks with F − use as promoted in dentistry [104,105]. However, the accumulative dose of F − including absorption spikes in ECF should not exceed 1part per million (ppm) to avoid fluorosis [106].…”

Section: Fluorinementioning

confidence: 99%

“…Optimal F − in the public water supply is more effective than oral administration for an optimal F − effect in all age groups [89,99,100]. For young children still forming teeth, fluoridated tooth paste must be carefully administered to avoid fluorosis particularly if the water supply is also fluoridated [103][104][105][106]. Adolescents and adults achieve FA protection on the outer surface and within the enamel rods via cyclic remineralization of enamel.…”

Section: Fluorinementioning

confidence: 99%

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Pathophysiology of Demineralization, Part I: Attrition, Erosion, Abfraction, and Noncarious Cervical Lesions

Roberts

Mangum

Schneider

2022

Curr Osteoporos Rep

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Purpose of the Review Compare pathophysiology for infectious and noninfectious demineralization disease relative to mineral maintenance, physiologic fluoride levels, and mechanical degradation. Recent Findings Environmental acidity, biomechanics, and intercrystalline percolation of endemic fluoride regulate resistance to demineralization relative to osteopenia, noncarious cervical lesions, and dental caries. Summary Demineralization is the most prevalent chronic disease in the world: osteoporosis (OP) >10%, dental caries ~100%. OP is severely debilitating while caries is potentially fatal. Mineralized tissues have a common physiology: cell-mediated apposition, protein matrix, fluid logistics (blood, saliva), intercrystalline ion percolation, cyclic demineralization/remineralization, and acid-based degradation (microbes, clastic cells). Etiology of demineralization involves fluid percolation, metabolism, homeostasis, biomechanics, mechanical wear (attrition or abrasion), and biofilm-related infections. Bone mineral density measurement assesses skeletal mass. Attrition, abrasion, erosion, and abfraction are diagnosed visually, but invisible subsurface caries <400μm cannot be detected. Controlling demineralization at all levels is an important horizon for cost-effective wellness worldwide.

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