A Case-Control Study on the p73 G4A Gene Polymorphism and Susceptibility to Breast Cancer in an Iranian Population

Abstract

<jats:p>Background: The tumor protein p73 (TP73) is a homolog of TP53 family. Ectopic p73 overexpression largely mimics p53 activities as a tumor suppressor and activates the transcription of p53-responsive genes and as a result induce apoptosis. This study aimed to investigate the association between p73 G4A polymorphism and the risk of breast cancer in a northeastern Iranian population.&#x0D; Methods: This case-control study was performed on 105 patients who admitted in educational hospitals of Mashhad University of Medical Sciences, Iran during 2013-2015, with breast cancer as case group and 120 healthy women as the control group. PCR-CTPP method was used to investigate the relationship between the p73 G4A polymorphism and the risk of breast cancer.&#x0D; Results: There was no significant association between the AA genotype of the p73 G4A polymorphism and breast cancer in case and control groups. Although G allele frequency was higher in the case group, the abundance of this allele between case and control groups was not statistically meaningful and, as a result, not associated with the risk of breast cancer in this study group.&#x0D; Conclusion: There was no association between G4A p73 polymorphism and the risk of breast cancer in a northeastern Iranian population.&#x0D; </jats:p>

Case-control Study on p73 rs1801173 C &gt; T Gene Polymorphism and Susceptibility to Gastric Cancer in a Chinese Han Population

“…Previous research demonstrated that p73 gene polymorphisms are related to the occurrence of various cancers, including esophageal cancer [17] , rectal cancer [18] , breast cancer [19] , lung cancer [20] , and cervical cancer [21] . However, no research could be found on p73 gene polymorphism and GC susceptibility.…”