A Case of a Diffuse B Cell Lymphoma Inducing Cardiac Tamponade in a Young Female

Yendamuri, Revanth; González, Daniel; Barve, Nishad; Bashir, Hanad

doi:10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2838

Cited by 1 publication

(2 citation statements)

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“…The standard diagnostic workup for PMBCL includes complete hematologic examination, total body CT, mediastinal mass biopsy, and bone marrow aspirate and biopsy [ 7 ]. Consistent with the current literature, our patient’s mediastinal mass biopsy results demonstrated positivity for CD20, CD79a, Bcl6, Bcl2, MUM1, c-myc, PD-L1, CD30, and Ki-67 [ 8 - 12 ]. Additionally, PMBCL classically does not involve the bone marrow, as is the case for our patient.…”

Section: Discussionsupporting

confidence: 90%

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Primary Mediastinal B-Cell Lymphoma Presenting as Cardiac Tamponade

Phan,

Randhawa,

Johnston

et al. 2023

J Med Cases

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Primary mediastinal B-cell lymphoma (PMBCL) is a rare subtype of non-Hodgkin lymphoma. Typical symptoms include cough, chest pain, and dyspnea; however, cardiac tamponade as the primary manifestation is exceedingly rare. We hereby present a case of a 34-year-old male with a past medical history of obesity, who presented to our emergency department with a chronic dry cough for 4 months. On admission, computed tomography demonstrated a large 11.1-cm diameter anterior mediastinal mass, and echocardiography demonstrated cardiac tamponade physiology. The patient underwent further workup including pericardiocentesis, subsequent pericardial window, and mediastinal biopsy, which demonstrated histopathology consistent with PMBCL. Our case highlights the importance of a complete and thorough workup for patients with chronic untraditional symptoms. This case is unique in that PMBCL is rarely associated with cardiac tamponade as the primary clinical presentation. Additionally, we recommend an extensive cardiac workup for patients presenting with a large mediastinal mass, as failure to do so may result in patient morbidity and mortality.

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Section: Discussionsupporting

confidence: 90%

“…PMBCL may present with pleural and pericardial effusions in up to approximately 50% of cases; however, cardiac tamponade as the primary manifestation of PMBCL is exceedingly rare. Only several case reports have noted cardiac tamponade as the primary diagnosis at the time of hospital admission [8][9][10][11][12].…”

Section: Discussionmentioning

confidence: 99%