A case of cellulitis-like foreign body reaction after hyaluronic acid dermal filler injection

Shin, Yo Sup; Kwon, Won Joo; Cho, Eun Byul; Park, Eun Joo; Kim, Kwang Ho

doi:10.1016/j.dsi.2017.06.004

Cited by 7 publications

(9 citation statements)

References 15 publications

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“…Foreign body reaction is the last step of the inflammation and wound healing process following the implantation of various materials into human tissue. This is supported by Shin et al, who reported similar findings in their case, which presented a cellulitis-like foreign body reaction after a hyaluronic acid dermal filler injection [ 4 ].…”

Section: Discussionsupporting

confidence: 77%

Orbital Compressed Air and Diesel Explosion Injury Resembling Orbital Cellulitis: An Unusual Case

2021

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Patient: Male, 44-year-old Final Diagnosis: Orbital celullitis with multiple abscesses and pneumoorbita of the right eye caused by orbital-compressed air and diesel explosion Symptoms: Worsening of the right upper eyelid swelling • accompanied by pain • fever • redness Medication: — Clinical Procedure: Ophthalmology examination • CT Scan • microorganism culture • laboratory test Specialty: Ophthalmology Objective: Unusual clinical course Background: In this observational case report, we describe a case of orbital cellulitis caused by blunt trauma from an orbital compressed air and diesel explosion injury. Case Report: A 44-year-old man presented to our emergency department with a marked clinical worsening of right upper eyelid swelling, accompanied by pain, fever, and redness. Four days prior, the patient’s right eye was struck by a pressurized diesel engine explosion. He sought treatment at another hospital, where an initial examination was conducted and a small laceration was found and immediately treated with irrigation and medication. The wound became progressively worse, and on examination at our hospital, we diagnosed orbital cellulitis, multiple abscesses, and pneumo-orbital formations. There was no indication of infection from the ears, nose, throat, and oral cavity, which usually causes orbital cellulitis. Drainage, debridement, incision, and necrotomy with orbital decompression (canthotomy and cantholysis procedure) was then performed on the patient. Conclusions: Diesel explosion injury can cause orbital cellulitis which can appear to be a simple case at first but has a poor prognosis. Therefore, evaluating the patient’s trauma history, computed tomography scan, and histopathological examination are essential in establishing the diagnosis. As early as possible, a diagnosis should be made to prevent tissue damage due to inflammation. Surgical debridement and the administration of a corticosteroid and antibiotic were key to managing the presented case.

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Section: Discussionsupporting

confidence: 77%

Orbital Compressed Air and Diesel Explosion Injury Resembling Orbital Cellulitis: An Unusual Case

2021

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“…As an example, 0.6% of patients injected with Restylane® documented an incidence of hypersensitivity, divided equally between immediate and delayed reactions (Bitterman-Deutsch et al, 2015 ; Pérez-Pérez et al, 2017 ). There are reported cases with different characteristics i.e., a case of cellulitis-like FBR after HA-dermal filler injection (Shin et al, 2018 ). For the above mentioned reasons, FBR and the fate of scaffolds implanted should be cautiously evaluated in the animal model (Dondossola et al, 2016 ).…”

Section: In Vivo Tests Of Ha-based Materialsmentioning

confidence: 99%

An Effective Translation: The Development of Hyaluronan-Based Medical Products From the Physicochemical, and Preclinical Aspects

Huerta-Ángeles

Nešporová

Ambrožová

et al. 2018

Front. Bioeng. Biotechnol.

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This review shows the steps toward material selection focalized on the design and development of medical devices based on hyaluronan (HA). The selection is based on chemical and mechanical properties, biocompatibility, sterilization, safety, and scale-up costs. These facts play a vital role in the industrialization process. Approved medical devices containing-HA are illustrated to identify key parameters. The first part of this work involves the steps toward a complete characterization of chemical and mechanical aspects, reproducibility of the processes and scale up. In a second stage, we aimed to describe the preclinical in vitro and in vivo assays and selected examples of clinical trials. Furthermore, it is important to keep in mind the regulatory affairs during the research and development (R&D) using standardization (ISO standards) to achieve the main goal, which is the functionality and safety of the final device. To keep reproducible experimental data to prepare an efficient master file for the device, based on quality and recorded manufacturing data, and a rigorous R&D process may help toward clinical translation. A strong debate is still going on because the denominated basic research in HA field does not pay attention to the purity and quality of the raw materials used during the development. So that, to achieve the next generation of devices is needed to overcome the limitations of state of art in terms of efficacy, biodegradability, and non-toxicity.

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“…One complication of dermal filler injection is foreign body reaction, which is the last step of inflammation and wound healing process 6 . The reaction demonstrates various clinical and histologic features.…”

Section: Discussionmentioning

confidence: 99%

Orbit mass secondary to migration of dermal hyaluronic acid filler

et al. 2019

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A case of cellulitis-like foreign body reaction after hyaluronic acid dermal filler injection

Cited by 7 publications

References 15 publications

Orbital Compressed Air and Diesel Explosion Injury Resembling Orbital Cellulitis: An Unusual Case

Orbital Compressed Air and Diesel Explosion Injury Resembling Orbital Cellulitis: An Unusual Case

An Effective Translation: The Development of Hyaluronan-Based Medical Products From the Physicochemical, and Preclinical Aspects

Orbit mass secondary to migration of dermal hyaluronic acid filler

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