A case of clinically mild encephalitis with a reversible splenial lesion (MERS) after mumps vaccination

Hara, Mitsuwo; Mizuochi, Tatsuki; Kawano, Go; Koike, Takayoshi; Shibuya, Ikuhiko; Ohya, Takashi; Ohbu, Keizo; Nagai, Kojiro; Nagamitsu, Shinichiro; Yamashita, Yushiro; Nakayama, Tetsuo; Matsuishi, Toyojiro

doi:10.1016/j.braindev.2010.12.013

Cited by 25 publications

(22 citation statements)

References 7 publications

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“…The most frequently reported clinical signs are: delirious behavior (54%); alteration of consciousness (35%) and epilepsy (33%) [11]. The particularity of this entity resides in the reversible clinical and radiological findings in the periods varying from 2 weeks to one month according to the authors [12].…”

Section: Discussionmentioning

confidence: 99%

Mild Encephalitis/Encephalopathy with a Reversible Splenial Lesion Due to Respiratory Syncytial Virus: Case Report

Makhlouf¹,

Messelmani²,

Bedoui³

et al. 2017

J Neuroinfect Dis

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Section: Discussionmentioning

confidence: 99%

Mild Encephalitis/Encephalopathy with a Reversible Splenial Lesion Due to Respiratory Syncytial Virus: Case Report

Makhlouf¹,

Messelmani²,

Bedoui³

et al. 2017

J Neuroinfect Dis

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“…(Table 1). [2–3,12,26,29–34] However, the exact pathogenesis of RESLES following infections is still controversial. A large body of evidence suggests that the manifestations of RESLES are related to inflammatory factors, such as interleukin 6, tumor necrosis factor-α, and soluble tumor necrosis factor receptor 1.…”

Section: Discussionmentioning

confidence: 99%

“…Patients with infection may be associated with hyponatremia. [29,31] When hyponatremia occurs, the osmotic pressure of the cells in the corpus callosum is decreased and the increased free water entered into the cells leading to cytotoxic edema eventually. [15] Tani et al [96] reviewed clinical date of 24 patients with RESLES and found that all of them had fever, suggesting that fever may be associated with RESLES.…”

Section: Discussionmentioning

confidence: 99%

“…One possible explanation for RESLES associated with AEDs is osmotic demyelination caused by fluid imbalance, including the alternations of sodium and glucose concentration. [29] An osmotic effect might be primarily caused by hyponatremia or other solute imbalances which play an important role in the pathogenesis. However, some authors believe the changes in the concentration of AEDs contributed to the pathogenesis of RESLES.…”

Section: Discussionmentioning

confidence: 99%

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Reversible splenial lesion syndrome associated with lobar pneumonia

Wu²,

Qi³

et al. 2016

Medicine

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Background:Reversible splenial lesion syndrome (RESLES) is a rare clinico-radiological disorder with unclear pathophysiology. Clinically, RESLES is defined as reversible isolated splenial lesions in the corpus callosum, which can be readily identified by magnetic resonance imaging (MRI) and usually resolve completely over a period of time. RESLES could be typically triggered by infection, antiepileptic drugs (AEDs), poisoning, etc. More factors are increasingly recognized.Methods and results:We reported herein an 18-year-old female patient with lobar pneumonia who developed mental abnormalities during hospitalization. An isolated splenial lesion in the corpus callosum was found by head MRI and the lesion disappeared 15 days later. Based on her clinical manifestations and radiological findings, she was diagnosed with lobar pneumonia associated RESLES. We further summarize the up-to-date knowledge about the etiology, possible pathogenesis, clinical manifestations, radiological features, treatment, and prognosis of RESLES.Conclusion:This report contributes to the clinical understanding of RESLES which may present with mental abnormalities after infection. The characteristic imaging of reversible isolated splenial lesions in the corpus callosum was confirmed in this report. The clinical manifestations and lesions on MRI could disappear naturally after 1 month without special treatment.

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“…12 Mumps Torii vaccine strain was isolated from his CSF. The patient had transient hallucinations, nuchal rigidity, and hyponatremia.…”

Section: How Do You Determine the Cause Of The Disease?mentioning

confidence: 99%

A 15-month-old boy with reduced consciousness and convulsion

Oikawa

Okumura

Oyama³

et al. 2012

Journal of Clinical Virology

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A case of clinically mild encephalitis with a reversible splenial lesion (MERS) after mumps vaccination

Cited by 25 publications

References 7 publications

Mild Encephalitis/Encephalopathy with a Reversible Splenial Lesion Due to Respiratory Syncytial Virus: Case Report

Mild Encephalitis/Encephalopathy with a Reversible Splenial Lesion Due to Respiratory Syncytial Virus: Case Report

Reversible splenial lesion syndrome associated with lobar pneumonia

A 15-month-old boy with reduced consciousness and convulsion

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