1990
DOI: 10.1007/bf02779365
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A case of coexisting malignant carcinoid tumor and adenocarcinoma in the papilla of vater

Abstract: A 47-year-old Japanese woman in whom obstructive jaundice had already been diagnosed, was found to have a dome-shaped elevated tumor approximately 3 cm in diameter located in the area very close to the papilla of Vater on endoscopical and radiographical investigations. Histopathologically, the resected tumor was composed mainly of solid nests of atypical argyrophilic cells, and partially of an area of well differentiated tubular adenocarcinoma, showing mutual transition in the mucosal layer. Both immunohistoch… Show more

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Cited by 24 publications
(15 citation statements)
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“…In this report, we described the second reported cytological case of MANEC with adenoma component of the ampulla of Vater, and analyzed the immunocytochemical characteristics of this type of tumor for the first time. To the best of our knowledge, only 16 cases of MANEC of the ampulla of Vater have been reported in the English language literature . Table summarizes the clinicopathological features of the previously reported cases as well as the present one.…”
Section: Discussionmentioning
confidence: 85%
See 1 more Smart Citation
“…In this report, we described the second reported cytological case of MANEC with adenoma component of the ampulla of Vater, and analyzed the immunocytochemical characteristics of this type of tumor for the first time. To the best of our knowledge, only 16 cases of MANEC of the ampulla of Vater have been reported in the English language literature . Table summarizes the clinicopathological features of the previously reported cases as well as the present one.…”
Section: Discussionmentioning
confidence: 85%
“…Mixed adenoneuroendocrine carcinoma (MANEC) is defined as a tumor that has morphologically recognizable both adenocarcinoma and neuroendocrine carcinoma (NEC) components comprising at least 30% of either component by the recent WHO Classification . The occurrence of MANEC in the ampulla of Vater is extremely rare; only 16 cases have been reported in the English language literature . Moreover, only two cases of cytological features of this type of rare tumor have been documented in one report …”
Section: Introductionmentioning
confidence: 99%
“…Almost all cases have been identifi ed in the ampulla of Vater and only nine cases have been reported in Japan. [4][5][6][7][8][9][10][11] Neuroendocrine cell carcinomas have been reported in the stomach and colorectum. [13][14][15] Neuroendocrine cell carcinoma has been suggested to originate from a pre-existing common histological type of adenocarcinoma, pre-existing carcinoid, nonneoplastic multipotent stem cells, or non-neoplastic immature endocrine cells.…”
Section: Discussionmentioning
confidence: 99%
“…3 Only nine cases of duodenal adenoendocrine cell carcinoma have been reported in Japan. [4][5][6][7][8][9][10][11] The lesions were located in the ampulla of Vater in all of the reported cases and no such lesions have previously been reported in the accessory papilla of the duodenum. This report presents a case demonstrating adenoendocrine carcinoma of the accessory papilla of the duodenum.…”
Section: Introductionmentioning
confidence: 99%
“…Mixed adenoneuroendocrine tumor located in the ampullary region is very rare. To the best of our knowledge, only 13 cases have been reported in the literature, none with cytological features described . We present two cases of MANEC of the ampulla of Vater with cytological findings and review literatures.…”
mentioning
confidence: 89%