A case of DENV and SARS-CoV-2 coinfection in Indonesia: The challenge of a dual outbreak?

Abstract

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Dengue and SARS-CoV-2 co-infection: A case series from Sri Lanka and literature review

“…Two cases had positive dengue serology. However, previous reports have stated not to use dengue virus antibody assay results as clinical decision-making tools in a coinfection as serological cross-reactivity between Dengue and COVID 19 has been documented [6,8]. The antigenic similarity between the two viruses has been identified as the potential cause for the cross-reactivity [1,6].…”

“…However, previous reports have stated not to use dengue virus antibody assay results as clinical decision-making tools in a coinfection as serological cross-reactivity between Dengue and COVID 19 has been documented [6,8]. The antigenic similarity between the two viruses has been identified as the potential cause for the cross-reactivity [1,6]. Hence, the production of anti-Dengue virus antibodies during SARS-CoV-2 infection can result in a false positive dengue IgM in confirmed COVID 19 cases [1].…”

“…Both Dengue virus and SAR-CoV-2 infections have similar clinical and laboratory features as well as the disease course making the differentiation between the two diseases difficult and there is always the possibility of coinfection [6,7]. Whether such coinfection may lead to greater severity is not yet known [7].…”