A Case of Diffuse Alveolar Hemorrhage Associated With Hyaluronic Acid Dermal Filler

Patient: Male, 61Final Diagnosis: Diffuse alveolar hemorrhageSymptoms: HemoptysisMedication: BivalirudinClinical Procedure: Percutaneous coronary interventionSpecialty: CardiologyObjective:Rare complication/diseaseBackground:Diffuse alveolar hemorrhage (DAH) is a rare but potentially fatal complication of anticoagulant or antiplatelet therapy. Bivalirudin is a specific and reversible direct thrombin inhibitor (DTI).Case Report:We report a case of severe DAH, possibly related to bivalirudin use, in a 61-year-old patient undergoing coronary intervention. The patient had presented with an out-of-hospital cardiac arrest due to acute ST elevation myocardial infarction (STEMI). During the coronary intervention, shortly after receiving bivalirudin, the patient started having frank bleeding from the endotracheal tube and developed hemodynamic compromise. Despite aggressive intervention and intensive care, the patient died.Conclusions:At this time, to our knowledge, there have been no reports of DAH associated with the use of bivalirudin.

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Effects of hyaluronic acid on bleeding following third molar extraction

Göçmen

Aktop

Alev

et al. 2017

J. Appl. Oral Sci.

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Objective To explore the effects of hyaluronic acid (HA) on bleeding and associated outcomes after third molar extraction.Methods Forty patients who had undergone molar extraction were randomly divided into two groups; 0.8% (w/v) HA was applied to the HA group (n=20) whereas a control group (n=20) was not treated. Salivary and gingival tissue factor (TF) levels, bleeding time, maximum interincisal opening (MIO), pain scored on a visual analog scale (VAS), and the swelling extent were compared between the two groups.Results HA did not significantly affect gingival TF levels. Salivary TF levels increased significantly 1 week after HA application but not in the control group. Neither the VAS pain level nor MIO differed significantly between the two groups. The swelling extent on day 3 and the bleeding time were greater in the HA group than in the control group.Conclusions Local injection of HA at 0.8% prolonged the bleeding time, and increased hemorrhage and swelling in the early postoperative period after third molar extractions.

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A Case of Diffuse Alveolar Hemorrhage Associated With Hyaluronic Acid Dermal Filler

Cited by 4 publications

References 7 publications

Death from Pulmonary Embolism Caused by Vaginal Injection of Hyaluronic Acid: a Case Report and a Literature Review

Death from Pulmonary Embolism Caused by Vaginal Injection of Hyaluronic Acid: a Case Report and a Literature Review

A Case of Diffuse Alveolar Hemorrhage as a Possible Complication of Bivalirudin Therapy

Effects of hyaluronic acid on bleeding following third molar extraction

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