A case of eel collagen allergy

Tamura, Masao; Kobayashi, Yukihiro; Ogita, Chie; Tsuboi, Kazuyuki; Kusakabe, Minori; Azuma, Kota; Abe, Takeo; Yoshikawa, Takahiro; Sekiguchi, Mutsuo; Azuma, Naoto; Kitano, Masayasu; Sano, Hajime

doi:10.1016/j.alit.2017.04.012

Cited by 7 publications

(5 citation statements)

References 8 publications

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“…The risk of fish collagen-induced symptoms was considered low in people with fish allergies with no positive reactions (0/30, 0/3, respectively), in studies by Hansen et al [4] and André et al [5]. On the other hand, 4 cases of fish collagen allergy, in 3 adults and 1 child, have been reported recently: 1 involving eel consumption [6] and 3 involving ingestion of processed products (sweets and dietary supplements) containing fish collagen [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

A case of pediatric anaphylaxis caused by gummy tablets containing fish collagen

Ueno¹,

Takaoka²,

Shimojo

et al. 2020

Asia Pacific Allergy

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Fish collagen is one of the major allergens involved in fish allergies; however, it has not been well-established whether fish collagen can cause anaphylaxis among individuals with fish allergies, especially children. A 9-year-old girl experienced anaphylaxis after consuming 2 fruit-flavored gummy tablets. Contacting the manufacturing company revealed that fishderived collagen was used in the gummy tablets, and an oral fish collagen challenge test confirmed that the anaphylaxis was induced by fish collagen. Immunoblot analysis showed a 120-kDa band in a sample of the fish collagen in the gummy tablets, and no reactive band of the pork gelatin was observed. Additionally, salmon collagen and other fish samples that provoked symptoms were detected as a 120-kDa band in the immunoblot analysis. The 120-kDa band was identified as fish collagen by mass spectrometry confirming that it was the causative antigen of our patient's allergy. This case study confirms that fish collagen can cause anaphylaxis in children with fish allergies. Physicians and allergic individuals need to be aware that processed foods may contain fish collagen to avoid allergic reactions.

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Section: Introductionmentioning

confidence: 99%

A case of pediatric anaphylaxis caused by gummy tablets containing fish collagen

Ueno¹,

Takaoka²,

Shimojo

et al. 2020

Asia Pacific Allergy

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“…8 In the past decade, a few cases of fish collageninduced allergy have been reported in the literature. [3][4][5] Notably, all patients in the case reports experienced severe symptoms after intake of fish collagen and/or heated fish. Recently, the clinical relevance of fish collagen was investigated in a large patient population (n = 101).…”

Section: Ta B L E 1 Clinical Data Of Patients With Fish Allergymentioning

confidence: 97%

“…β-parvalbumin and collagen, which are both well-known fish allergens, are cross-reactive allergens present in various species of fish (reviewed in Kuehn 1 ). 2 A few recent case studies reported that fish collagen induced severe allergies [3][4][5] ; however, no significant relationship was evident between the severity of the symptoms and the collagen-specific IgE reactivity. In this study, we investigated, for the first time, the relationship between the severity of the symptoms and sensitization to fish collagen in Japanese patients with fish allergy.…”

Section: Fish Collagen As a Potential Indicator Of Severe Allergic Re...mentioning

confidence: 99%

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Fish collagen as a potential indicator of severe allergic reactions among patients with fish allergies

Shimojo

Yagami

Ohno

et al. 2021

Clin Experimental Allergy

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“…In another study, based on the mouse model sensitized by turbot parvalbumin, it is known that parvalbumin eel can cross-react with parvalbumin turbot [27]. In addition, in 2018 there was a report on the incidence of atopic dermatitis which was triggered by an allergy to eel collagen [28].…”

Section: Eels (Monopterus Sp)mentioning

confidence: 99%

The Allergenicity Potential of Edible Freshwater Fish

Atika Hanum Falihah,

Muhammad Novrizal Abdi Sahid,

Ika Puspitasari

2023

J. Food Pharm. Sci

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A Freshwater fish is a popular type of fish consumed in Indonesia besides seawater fish. However, until now the most available information regarding the potential allergenicity of fish is only related to seawater fish. The potential allergenicity of freshwater fish has not been studied much, so it has not been identified and characterized. Based on this, this review aims to collect information regarding the potential allergenicity of protein in freshwater fish and the effect of processing on this potential. The potential allergenicity of proteins in several freshwater fish has been confirmed by immunoblotting and ELISA, namely mujair, nile, catfish, mas, toman, janjan, tambakan, tiger scat, barramundi, and eel. The identified allergenic proteins include parvalbumin, tropomyosin, enolase, aldolase, creatine kinase, triosephosphate isomerase, pyruvate kinase, lactate dehydrogenase, glucose-6-phosphate isomerase, and glyceraldehyde-3-phosphate dehydrogenase. In addition, several proteins in other freshwater fish also have allergenicity potential but have not been confirmed through research, namely pomfret, gourami, snakehead, catfish, eel, betutu, and cetol. The potential allergenicity of fish protein is also influenced by the processing process. Changes in the potential allergenicity are related to the characteristics of each allergen protein. Therefore, it is necessary to select the appropriate processing so that potential allergenicity can be suppressed.

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A case of eel collagen allergy

Cited by 7 publications

References 8 publications

A case of pediatric anaphylaxis caused by gummy tablets containing fish collagen

A case of pediatric anaphylaxis caused by gummy tablets containing fish collagen

Fish collagen as a potential indicator of severe allergic reactions among patients with fish allergies

The Allergenicity Potential of Edible Freshwater Fish

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