A Case of Hypokalemia Possibly Induced by Nafcillin

Gutiérrez, Fernando Casado; Mudunuru, Sitarama Arvind; Nasr, Rabih

doi:10.3390/antibiotics7040108

Cited by 7 publications

(3 citation statements)

References 10 publications

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“…It is known that the metabolic byproducts of some antibiotics, such as tetracyclines, accumulate inside the mitochondria of renal cells and prevent oxidative phosphorylation, leading to metabolic acidosis [ 29 ]. Acidosis is often concomitant with reduced plasma calcium and chloride levels [ 30 ]. The histopathological observations of the current study further confirmed the cellular damage.…”

Section: Discussionmentioning

confidence: 99%

Impacts of Oral Florfenicol Medication and Residues on the Kidney and Liver of Nile Tilapia Oreochromis niloticus (L.)

Bardhan

Abraham

Singha

et al. 2023

Veterinary Sciences

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Florfenicol (FFC), an approved aquaculture antibiotic, is administered in feed at doses of 10–15 mg kg biomass−1 day−1 for 10 successive days. In this study, healthy Oreochromis niloticus were fed with 0–10 times the therapeutic dose of 15 mg kg biomass−1 day−1 for 10 days and tracked for 43 days post dosing. Assessments of residue accrual and depletion, oxidative stress, serum biochemistry, histopathology and extent of kidney and liver damages were made. FFC dosing reduced the feed intake significantly. The therapeutic dose produced no mortalities on day 10. Dose-dependent alterations in serum biochemistry were noted upon dosing. Several histopathological alterations were observed in the kidney and liver, which vindicated the toxic potentials of FFC. The residual FFC and florfenicol amine (FFA) accrual, depletion and oxidative stress responses, such as increased malondialdehyde, total nitric oxide, ferric reducing antioxidant power and reduced glutathione S-transferase activity, were documented. The dietary FFC persuaded the physiological state of O. niloticus, the effects of which normalized sparsely with time upon cessation of dosing at the higher doses. The study provided a brief outlook on the physiological responses upon oral FFC administration, which should be kept in mind during its application for fish health safety purposes.

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Section: Discussionmentioning

confidence: 99%

Impacts of Oral Florfenicol Medication and Residues on the Kidney and Liver of Nile Tilapia Oreochromis niloticus (L.)

Bardhan

Abraham

Singha

et al. 2023

Veterinary Sciences

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“…Symptoms of hypokalemia include muscle weakness, cramping, fatigue, and constipation. Severe hypokalemia can be life-threatening, leading to muscle paralysis, respiratory failure, or heart arrhythmias [ 69 ].…”

Section: Essential Metals In Foodmentioning

confidence: 99%

Metals on the Menu—Analyzing the Presence, Importance, and Consequences

Milanković,

Tasić,

Leskovac

et al. 2024

Foods

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Metals are integral components of the natural environment, and their presence in the food supply is inevitable and complex. While essential metals such as sodium, potassium, magnesium, calcium, iron, zinc, and copper are crucial for various physiological functions and must be consumed through the diet, others, like lead, mercury, and cadmium, are toxic even at low concentrations and pose serious health risks. This study comprehensively analyzes the presence, importance, and consequences of metals in the food chain. We explore the pathways through which metals enter the food supply, their distribution across different food types, and the associated health implications. By examining current regulatory standards for maximum allowable levels of various metals, we highlight the importance of ensuring food safety and protecting public health. Furthermore, this research underscores the need for continuous monitoring and management of metal content in food, especially as global agricultural and food production practices evolve. Our findings aim to inform dietary recommendations, food fortification strategies, and regulatory policies, ultimately contributing to safer and more nutritionally balanced diets.

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“…Several mechanisms have been associated with amphotericin B-induced electrolyte disturbances such as changes in the Na+-K+-ATPase pump in the distal tubule, and increased absorption of Na+ in the gastrointestinal tract, with resultant excretion of K+ in the feces. 3,15…”

Section: Renal Lossmentioning

confidence: 99%

Hypokalemia, how to clarify and treat: a review article

Paramita Dwisari Putri,

Suryana

2023

Int J Adv Med

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Hypokalemia is a frequent electrolyte disturbance in clinical practice and in hospitalized patients. Potassium disturbances are common and have been associated with increased mortality in several populations. The incidence of hypokalemia often occurs refractory and without a clear cause so very difficult to prevent and can increase risk of recurring conditions and require treatment. Through this overview will discuss what are the underlying causes of hypokalemia and what tests are needed to find out the cause of hypokalemia so that it can remind health worker and to prevent recurrence of emergencies conditions due to hypokalemia. The type of study is used literature review. In addition, the purpose of this study method is to reveal various theories that are relevant to the diagnostic approach to determine the causes of hypokalemia so that it can be used as reference material in daily practice. Hypokalemia is usually a sign of various diseases that can cause emergency conditions. If the cause is not known for certain, it will cause recurrent hypokalemia. It is important for health workers to conduct interviews to find out the patient's medical history, physical examination and comprehensive supporting examinations to determine the cause of hypokalemia. Comprehensive management is needed and must be done immediately so that the condition of hypokalemia does not lead to emergency conditions. In some patients, such as in endocrine related hypokalemia cases, multidisciplinary diagnostic and therapeutic approach is needed.

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A Case of Hypokalemia Possibly Induced by Nafcillin

Cited by 7 publications

References 10 publications

Impacts of Oral Florfenicol Medication and Residues on the Kidney and Liver of Nile Tilapia Oreochromis niloticus (L.)

Impacts of Oral Florfenicol Medication and Residues on the Kidney and Liver of Nile Tilapia Oreochromis niloticus (L.)

Metals on the Menu—Analyzing the Presence, Importance, and Consequences

Hypokalemia, how to clarify and treat: a review article

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