A Case of Idiopathic Pulmonary Haemosiderosis with Myocarditis

Idiopathic pulmonary haemosiderosis with myocarditis. Radio-isotope studies in a patient treated with prednisone.

“…The lung changes are typical and the appearances in the heart are similar to those described by Campbell and Macafee (1959). The relationship between the heart and lung changes is uncertain.…”

“…The relationship between the heart and lung changes is uncertain. That the combination is fortuitous is unlikely, since the association of idiopathic pulmonary haemosiderosis with a myocarditis or myocardial abnormality other than cor pulmonale has been reported in at least nine other subjects in the past (Gellerstedt, 1939;Glanzmann and Walthard, 1941 ;Scheidegger and Dreyfus, 1945;Wigod, 1955;Soergel, 1957;Campbell and Macafee, 1959;Saltzman, West, and Chomet, 1962;Murphy, 1965). Nor is it likely that the pulmonary changes are secondary to cardiac damage, as pulmonary haemosiderosis similar to that found with severe mitral stenosis or prolonged left ventricular failure has not, so far as the authors are aware, been reported with other cardiac abnormalities.…”

Idiopathic Pulmonary Haemosiderosis and Rheumatoid Arthritis

“…Other disorders which could be due to a disturbance of the immune mechanism have been recorded in association with idiopathic pulmonary haemosiderosis-for example, myocarditis (Campbell and Macafee, 1959;Murphy, 1965) ; glomerulonephritis (Heptinstall and Salmon, 1959) ; polyarthritis and glomerulonephritis (Leschke, 1957). Goodpasture's syndrome -pulmonary haemorrhage (purpura, haemosiderosis) and glomerulonephritis-is thought by many to be a variation of idiopathic pulmonary haemosiderosis (Elder et al, 1965).…”

Pulmonary Haemosiderosis (apparently Idiopathic) associated with Myocarditis, with Bilateral Penetrating Corneal Ulceration, and with Diabetes Mellitus

“…Their patient, died aged 19 of cardiac failure with a heart weight of 1,100 mg. at necropsy: no details of the histology of the heart were given. Campbell and Macafee (1959) found descriptions of five other cases in which myocardial change was mentioned. They considered that the pulmonary haemosiderosis in their own case was idiopathic and not secondary to myocarditis, mainly on cardiac catheter findings, which excluded pulmonary hypertension.…”

“…The literature of pulmonary haemosiderosis includes an account by Campbell and Macafee (1959) of idiopathic pulmonary haemosiderosis associated with myocarditis. Their patient first had symptoms of shortness of breath at the age of 7; he was found to have the radiological changes of pulmonary haemosiderosis at the age of 12, and he died when 14 years old.…”