A case of immune-complex type glomerulonephritis associated with dermatomyositis.

Moriyama, Tokushi; Uruta, Yuji; Yamaguchi, Hiroshi; Fukuzaki, Makoto; Uchida, Yoshio; Yasumoto, Yûichiroh; Yamashita, Wataru; Harada, Ryuji; Ohsaki, Kazuya; Nakajima, Akira

doi:10.2169/naika.78.994

Cited by 8 publications

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“…As for the study by Couvrat-Desvergnes et al, they identified 14 patients who had undergone renal biopsy (6 PM, 5 DM, and 3 ASS), which revealed the presence of glomerulonephritis with various pathologic patterns including immune complex-related glomerulonephritis (n � 4), membranous nephropathy (n � 2), and IgA nephropathy (n � 2) [5]. We conducted an additional literature search and retrieved case reports describing the association of PM or DM with a variety of pathological glomerular lesions, including mesangial proliferative glomerulonephritis [21][22][23][24][25], membranous nephropathy [26][27][28][29][30][31], membranoproliferative glomerulonephritis [32], IgA nephropathy [33][34][35][36][37], diffuse proliferative glomerulonephritis [38], immune complex-type glomerulonephritis [39][40][41][42], acute interstitial nephritis [43], lipoid nephrosis and focal glomerulosclerosis [44], focal segmental glomerulosclerosis with evidence of acute tubular injury [45], sclerotic GN with fibrocellular crescent [46], and crescentic glomerulonephritis associated with malignancy [47]. Cases presenting with anti-neutrophil cytoplasmic antibody-associated glomerulonephritis in the context of DM have also been reported [48][49][50].…”

Section: Discussionmentioning

confidence: 99%

Nephrotic Syndrome as an Extramuscular Manifestation of Anti-EJ Antibody-Positive Dermatomyositis: A Case Report and Review of the Literature

Tsubouchi

Mizuuchi

Yamamoto

et al. 2022

Case Reports in Rheumatology

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Renal involvement is underestimated as an extramuscular manifestation of dermatomyositis (DM). Here, we describe a 67-year-old woman with anti-glycyl-transfer ribonucleic acid synthetase (anti-EJ) antibody and anti-ribonucleoprotein antibody-positive DM complicated by systemic sclerosis, who developed nephrotic syndrome concurrently with the exacerbation of DM, as indicated by incremental serum creatine kinase levels, high-intensity lesions on muscle magnetic resonance imaging, and active interstitial pneumonitis on chest computed tomography. Renal biopsy revealed the presence of immune-deposition in the glomerulus by immunofluorescence. To our knowledge, this is the first report describing the coexistence of anti-EJ antibody-positive DM and nephrotic syndrome. More reports of similar cases are warranted to substantiate the association.

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Section: Discussionmentioning

confidence: 99%

Nephrotic Syndrome as an Extramuscular Manifestation of Anti-EJ Antibody-Positive Dermatomyositis: A Case Report and Review of the Literature

Tsubouchi

Mizuuchi

Yamamoto

et al. 2022

Case Reports in Rheumatology

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Diffuse proliferative glomerulonephritis associated with dermatomyositis with nephrotic syndrome

Xie

Liu

et al. 2009

Rheumatol Int

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We described a 44-year-old man developing dermatomyositis (DM) and nephrotic syndrome (NS). Renal biopsy revealed diffuse proliferative glomerulonephritis (DPGN) with depositions of immunoglobulin and complements. A combination therapy of steroid and cyclophosphamide (CTX) was found very effective for the patient. Chronic glomerulonephritis is rare in DM. In our review of related literature, membranous glomerulonephritis (MN) is the main type of glomerular lesion, another type is mesangial proliferative glomerulonephritis (mesPGN). Here we reported a case of DM associated with DPGN developing NS, which was not found in existing literature. Although glomerulonephritis is uncommon in patients with DM, renal pathology is not as simplex as previously thought, and treatment with steroid or/and cytotoxic drugs is favorable for prognosis.

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Polymyositis associated with focal mesangial proliferative glomerulonephritis with depositions of immune complexes

et al. 2006

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A 58-year-old man concurrently developed polymyositis (PM), interstitial lung disease, and nephrotic-range proteinuria. Renal biopsy revealed focal mesangial proliferative glomerulonephritis (mesPGN) with depositions of immunoglobulin and complements. A combination therapy of corticosteroid, intravenous immunoglobulin, and cyclosporine was found very effective for the patient. Glomerulonephritis associated with PM/dermatomyositis (DM) is rare. In our review of related literature, mesPGN was exclusively observed in polymyositis while membranous nephropathy in DM. The mechanism underlying the association between myositis and glomerulonephritis remains to be elucidated.

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A case of immune-complex type glomerulonephritis associated with dermatomyositis.

Cited by 8 publications

References 0 publications

Nephrotic Syndrome as an Extramuscular Manifestation of Anti-EJ Antibody-Positive Dermatomyositis: A Case Report and Review of the Literature

Nephrotic Syndrome as an Extramuscular Manifestation of Anti-EJ Antibody-Positive Dermatomyositis: A Case Report and Review of the Literature

Diffuse proliferative glomerulonephritis associated with dermatomyositis with nephrotic syndrome

Polymyositis associated with focal mesangial proliferative glomerulonephritis with depositions of immune complexes

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